Idiopathic Parkinson Disease
Item
patients with idiopathic pd
boolean
C0030567 (UMLS CUI [1])
Motor fluctuations averaging at least 1 hour daily, not including morning akinesia
Item
patients with motor fluctuations averaging at least 1 hour daily in the off state during the waking hours (not including morning akinesia)
boolean
C1868976 (UMLS CUI [1,1])
C0449238 (UMLS CUI [1,2])
C0332173 (UMLS CUI [1,3])
C0332170 (UMLS CUI [1,4])
C0085623 (UMLS CUI [1,5])
C1705847 (UMLS CUI [1,6])
MDS-UPDRS - Hoehn and Yahr Stage
Item
patients with a modified hoehn and yahr stage <5 in the off state
boolean
C3639483 (UMLS CUI [1])
Optimised levodopa therapy duration | Optimised dopa decarboxylase inhibitor (ddi) therapy duration
Item
patients taking optimised levodopa/dopa decarboxylase inhibitor (ddi) therapy for at least 14 days prior to baseline
boolean
C0023570 (UMLS CUI [1,1])
C2698650 (UMLS CUI [1,2])
C0449238 (UMLS CUI [1,3])
C0598272 (UMLS CUI [2,1])
C2698650 (UMLS CUI [2,2])
C0449238 (UMLS CUI [2,3])
Quantity of daily doses of levodopa, except a bedtime dose
Item
patients receiving at least 3 daily doses of levodopa, not including a bedtime dose, and not more than 8 daily doses of levodopa
boolean
C0023570 (UMLS CUI [1,1])
C0178602 (UMLS CUI [1,2])
C1265611 (UMLS CUI [1,3])
C0521112 (UMLS CUI [1,4])
C3174092 (UMLS CUI [1,5])
C1705847 (UMLS CUI [1,6])
Ability to keep accurate 24-hour diaries
Item
patient who have demonstrated the ability to keep accurate 24-hour diaries prior to randomisation
boolean
C3890583 (UMLS CUI [1,1])
C0205197 (UMLS CUI [1,2])
C0443131 (UMLS CUI [1,3])
Clinically significant or unstable comorbidity
Item
patients with a clinically significant or unstable medical or surgical condition that would preclude his/her safe and complete study participation
boolean
C0009488 (UMLS CUI [1,1])
C2826293 (UMLS CUI [1,2])
C0009488 (UMLS CUI [2,1])
C0443343 (UMLS CUI [2,2])
Concomitant Therapy contraindicated according to the azilect®
Item
patients taking any disallowed medication according to the azilect® approved label
boolean
C1707479 (UMLS CUI [1,1])
C1444657 (UMLS CUI [1,2])
C0525678 (UMLS CUI [1,3])
C0013191 (UMLS CUI [1,4])
Recent use of mao inhibitors
Item
patients taking mao inhibitors within 3 months prior to baseline visit
boolean
C0026457 (UMLS CUI [1,1])
C0332185 (UMLS CUI [1,2])
Hypersensitivity to selegiline
Item
patients with a known serious adverse reaction to selegiline
boolean
C0036579 (UMLS CUI [1,1])
C0020517 (UMLS CUI [1,2])
Significant mental disorder compromising the ability to provide an informed consent or to participate fully in the study
Item
patients with a clinically significant psychiatric illness, including a major depression, which compromises their ability to provide consent or participate fully in the study
boolean
C0004936 (UMLS CUI [1,1])
C0750502 (UMLS CUI [1,2])
C0021430 (UMLS CUI [1,3])
C0085732 (UMLS CUI [1,4])
C2945640 (UMLS CUI [1,5])
C0004936 (UMLS CUI [2,1])
C0750502 (UMLS CUI [2,2])
C2348568 (UMLS CUI [2,3])
C0085732 (UMLS CUI [2,4])
C2945640 (UMLS CUI [2,5])
Mini-mental state examination
Item
patients with a mini mental state examination (mmse) score <=24
boolean
C0451306 (UMLS CUI [1])
Melanoma diagnosis | History of melanoma | Suspicious lesion
Item
patients with a diagnosis of melanoma or a history of melanoma, or a suspicious lesion
boolean
C0025202 (UMLS CUI [1])
C0025202 (UMLS CUI [2,1])
C0262926 (UMLS CUI [2,2])
C0037284 (UMLS CUI [3,1])
C0750493 (UMLS CUI [3,2])
C0025202 (UMLS CUI [3,3])