age at least 18 Years
Item
age at least 18 Years
boolean
C0001779 (UMLS CUI 2011AA)
397669002 (SNOMED CT 2011_0131)
Have histological evidence of a diagnosis of HCC not amenable to curative surgery
Item
Have histological evidence of a diagnosis of HCC not amenable to curative surgery
boolean
C0205462 (UMLS CUI 2011AA)
67151002 (SNOMED CT 2011_0131)
C0332120 (UMLS CUI 2011AA)
18669006 (SNOMED CT 2011_0131)
C0011900 (UMLS CUI 2011AA)
439401001 (SNOMED CT 2011_0131)
MTHU008876 (LOINC Version 232)
C2239176 (UMLS CUI 2011AA)
10049010 (MedDRA 14.1)
C0332197 (UMLS CUI 2011AA)
2667000 (SNOMED CT 2011_0131)
C1704632 (UMLS CUI 2011AA)
C1511562 (UMLS CUI 2011AA)
Serum alpha fetoprotein >= 1.5 Upper Limits of Normal
Item
Serum alpha fetoprotein >= 1.5 Upper Limits of Normal
boolean
C1271652 (UMLS CUI 2011AA)
391516001 (SNOMED CT 2011_0131)
C1519815 (UMLS CUI 2011AA)
Child-Pugh Stage A
Item
Child-Pugh Stage A
boolean
C4050412 (UMLS CUI 2011AA)
C0441778 (UMLS CUI 2011AA)
261618000 (SNOMED CT 2011_0131)
Have the presence of measurable disease as defined by the Response Evaluation Criteria in Solid Tumors (RECIST 1.1). A lesion that has been previously treated by local therapy will qualify as a measurable or evaluable lesion if there was demonstrable progression following locoregional therapy
Item
Have the presence of measurable disease as defined by the Response Evaluation Criteria in Solid Tumors (RECIST 1.1). A lesion that has been previously treated by local therapy will qualify as a measurable or evaluable lesion if there was demonstrable progression following locoregional therapy
boolean
C0150312 (UMLS CUI 2011AA)
52101004 (SNOMED CT 2011_0131)
C1513041 (UMLS CUI 2011AA)
C1704788 (UMLS CUI 2011AA)
C1709926 (UMLS CUI 2011AA)
Have given written informed consent prior to any study-specific procedures
Item
Have given written informed consent prior to any study-specific procedures
boolean
C0184704 (UMLS CUI 2011AA)
55149002 (SNOMED CT 2011_0131)
C0332152 (UMLS CUI 2011AA)
288556008 (SNOMED CT 2011_0131)
C2348558 (UMLS CUI 2011AA)
Have adequate hematologic, hepatic and renal function
Item
Have adequate hematologic, hepatic and renal function
boolean
C0205411 (UMLS CUI 2011AA)
88323005 (SNOMED CT 2011_0131)
C0221130 (UMLS CUI 2011AA)
86084001 (SNOMED CT 2011_0131)
C0232741 (UMLS CUI 2011AA)
79036002 (SNOMED CT 2011_0131)
C0232804 (UMLS CUI 2011AA)
11953005 (SNOMED CT 2011_0131)
Have a performance status of <= 1 on the Eastern Cooperative Oncology Group (ECOG) scale
Item
ECOG performance status finding <= 1
boolean
C1520224 (UMLS CUI 2011AA)
424122007 (SNOMED CT 2011_0131)
Have received sorafenib and have progressed or were intolerant to sorafenib or are ineligible for sorafenib treatment
Item
Have received sorafenib and have progressed or were intolerant to sorafenib or are ineligible for sorafenib treatment
boolean
C1514756 (UMLS CUI 2011AA)
C1516119 (UMLS CUI 2011AA)
422042001 (SNOMED CT 2011_0131)
C1947901 (UMLS CUI 2011AA)
C1744706 (UMLS CUI 2011AA)
C1555471 (UMLS CUI 2011AA)
NELG (HL7 V3 2006_05)
C1516119 (UMLS CUI 2011AA)
422042001 (SNOMED CT 2011_0131)
C0039798 (UMLS CUI 2011AA)
Are reliable and willing to make themselves available for the duration of the study and are willing to follow study procedures
Item
Are reliable and willing to make themselves available for the duration of the study and are willing to follow study procedures
boolean
C2347947 (UMLS CUI 2011AA)
C0600109 (UMLS CUI 2011AA)
225466006 (SNOMED CT 2011_0131)
C0470187 (UMLS CUI 2011AA)
103328004 (SNOMED CT 2011_0131)
C0489652 (UMLS CUI 2011AA)
MTHU024501 (LOINC Version 232)
C0525058 (UMLS CUI 2011AA)
Males and females with reproductive potential must agree to use medically approved contraceptive precautions during the trial and for 3 months following the last dose of study drug
Item
Males and females with reproductive potential must agree to use medically approved contraceptive precautions during the trial and for 3 months following the last dose of study drug
boolean
C0086582 (UMLS CUI 2011AA)
248153007 (SNOMED CT 2011_0131)
M (HL7 V3 2006_05)
C0086287 (UMLS CUI 2011AA)
248152002 (SNOMED CT 2011_0131)
F (HL7 V3 2006_05)
C0035150 (UMLS CUI 2011AA)
C0237399 (UMLS CUI 2011AA)
C0680240 (UMLS CUI 2011AA)
C0700589 (UMLS CUI 2011AA)
146680009 (SNOMED CT 2011_0131)
10010808 (MedDRA 14.1)
Females with childbearing potential must have had a negative serum pregnancy test <= 7 days prior to the first dose of study drug
Item
Females with childbearing potential must have had a negative serum pregnancy test <= 7 days prior to the first dose of study drug
boolean
C0086287 (UMLS CUI 2011AA)
248152002 (SNOMED CT 2011_0131)
F (HL7 V3 2006_05)
C1148523 (UMLS CUI 2011AA)
C0237399 (UMLS CUI 2011AA)
C0027552 (UMLS CUI 2011AA)
410525008 (SNOMED CT 2011_0131)
C0430061 (UMLS CUI 2011AA)
166435006 (SNOMED CT 2011_0131)
Are able to swallow capsules or tablets
Item
Are able to swallow capsules or tablets
boolean
C2712086 (UMLS CUI 2011AA)
288936000 (SNOMED CT 2011_0131)
C0006935 (UMLS CUI 2011AA)
385049006 (SNOMED CT 2011_0131)
CAP (HL7 V3 2006_05)
C0039225 (UMLS CUI 2011AA)
385055001 (SNOMED CT 2011_0131)
TAB (HL7 V3 2006_05)
Are currently enrolled in, or discontinued within the last 28 days from a clinical trial involving an investigational drug or device or not approved use of a drug or device (other than the study drug used in this study), or concurrently enrolled in any other type of medical research judged not to be scientifically or medically compatible with this study
Item
Are currently enrolled in, or discontinued within the last 28 days from a clinical trial involving an investigational drug or device or not approved use of a drug or device (other than the study drug used in this study), or concurrently enrolled in any other type of medical research judged not to be scientifically or medically compatible with this study
boolean
C1516879 (UMLS CUI 2011AA)
C0008976 (UMLS CUI 2011AA)
110465008 (SNOMED CT 2011_0131)
C0013230 (UMLS CUI 2011AA)
C2346570 (UMLS CUI 2011AA)
C0681814 (UMLS CUI 2011AA)
C0679426 (UMLS CUI 2011AA)
C0150312 (UMLS CUI 2011AA)
52101004 (SNOMED CT 2011_0131)
C0008976 (UMLS CUI 2011AA)
110465008 (SNOMED CT 2011_0131)
Known HCC with fibro-lamellar or mixed histology
Item
Known HCC with fibro-lamellar or mixed histology
boolean
C0334287 (UMLS CUI 2011AA)
253018005 (SNOMED CT 2011_0131)
C2239176 (UMLS CUI 2011AA)
10049010 (MedDRA 14.1)
C0205430 (UMLS CUI 2011AA)
26242008 (SNOMED CT 2011_0131)
C0344441 (UMLS CUI 2011AA)
10062005 (MedDRA 14.1)
MTHU010496 (LOINC Version 232)
Presence of clinically relevant ascitis
Item
Presence of clinically relevant ascitis
boolean
C0150312 (UMLS CUI 2011AA)
52101004 (SNOMED CT 2011_0131)
C0205210 (UMLS CUI 2011AA)
58147004 (SNOMED CT 2011_0131)
C2347946 (UMLS CUI 2011AA)
CL415363 (UMLS CUI 2011AA)
History of liver transplant
Item
History of liver transplant
boolean
CL421546 (UMLS CUI 2011AA)
392521001 (SNOMED CT 2011_0131)
C0023911 (UMLS CUI 2011AA)
18027006 (SNOMED CT 2011_0131)
10024714 (MedDRA 14.1)
50.5 (ICD-9-CM Version 2011)
Have received > 1 line of systemic treatment
Item
Have received > 1 line of systemic treatment
boolean
C1514756 (UMLS CUI 2011AA)
C0439093 (UMLS CUI 2011AA)
276140008 (SNOMED CT 2011_0131)
GT (HL7 V3 2006_05)
C0205447 (UMLS CUI 2011AA)
38112003 (SNOMED CT 2011_0131)
CL415196 (UMLS CUI 2011AA)
C1515119 (UMLS CUI 2011AA)
Have moderate or severe cardiac disease:
Item
Have moderate or severe cardiac disease:
boolean
C0205082 (UMLS CUI 2011AA)
24484000 (SNOMED CT 2011_0131)
C1881878 (UMLS CUI 2011AA)
C0018799 (UMLS CUI 2011AA)
56265001 (SNOMED CT 2011_0131)
10061024 (MedDRA 14.1)
Have the presence of cardiac disease, including a myocardial infarction within 6 months prior to study entry, unstable angina pectoris, New York Heart Association (NYHA) Class III/IV congestive heart failure, or uncontrolled hypertension
Item
Have the presence of cardiac disease, including a myocardial infarction within 6 months prior to study entry, unstable angina pectoris, New York Heart Association (NYHA) Class III/IV congestive heart failure, or uncontrolled hypertension
boolean
C0150312 (UMLS CUI 2011AA)
52101004 (SNOMED CT 2011_0131)
C0018799 (UMLS CUI 2011AA)
56265001 (SNOMED CT 2011_0131)
10061024 (MedDRA 14.1)
C0027051 (UMLS CUI 2011AA)
22298006 (SNOMED CT 2011_0131)
10028596 (MedDRA 14.1)
MTHU035551 (LOINC Version 232)
I21-I22 (ICD-10-CM Version 2010)
410 (ICD-9-CM Version 2011)
E10152 (CTCAE 1105E)
C0002965 (UMLS CUI 2011AA)
4557003 (SNOMED CT 2011_0131)
10002388 (MedDRA 14.1)
I20.0 (ICD-10-CM Version 2010)
411.1 (ICD-9-CM Version 2011)
C1319795 (UMLS CUI 2011AA)
420913000 (SNOMED CT 2011_0131)
10064081 (MedDRA 14.1)
C1319796 (UMLS CUI 2011AA)
422293003 (SNOMED CT 2011_0131)
10064082 (MedDRA 14.1)
C0018802 (UMLS CUI 2011AA)
42343007 (SNOMED CT 2011_0131)
10007559 (MedDRA 14.1)
MTHU020787 (LOINC Version 232)
I50.9 (ICD-10-CM Version 2010)
428.0 (ICD-9-CM Version 2011)
C1868885 (UMLS CUI 2011AA)
10066860 (MedDRA 14.1)
Have documented major electrocardiogram (ECG) abnormalities at the investigator's discretion
Item
Have documented major electrocardiogram (ECG) abnormalities at the investigator's discretion
boolean
C1301725 (UMLS CUI 2011AA)
397934002 (SNOMED CT 2011_0131)
C0205164 (UMLS CUI 2011AA)
255603008 (SNOMED CT 2011_0131)
C1623258 (UMLS CUI 2011AA)
46825001 (SNOMED CT 2011_0131)
10014084 (MedDRA 14.1)
C1704258 (UMLS CUI 2011AA)
Have major abnormalities documented by echocardiography with Doppler. For additional details
Item
Have major abnormalities documented by echocardiography with Doppler. For additional details
boolean
C0205164 (UMLS CUI 2011AA)
255603008 (SNOMED CT 2011_0131)
C1704258 (UMLS CUI 2011AA)
C1301725 (UMLS CUI 2011AA)
397934002 (SNOMED CT 2011_0131)
C0013520 (UMLS CUI 2011AA)
10053094 (MedDRA 14.1)
Have predisposing conditions that are consistent with development of aneurysms of the ascending aorta or aortic stress
Item
Have predisposing conditions that are consistent with development of aneurysms of the ascending aorta or aortic stress
boolean
C0012655 (UMLS CUI 2011AA)
76522002 (SNOMED CT 2011_0131)
C1511795 (UMLS CUI 2011AA)
C0856747 (UMLS CUI 2011AA)
425963007 (SNOMED CT 2011_0131)
10002347 (MedDRA 14.1)
C0003483 (UMLS CUI 2011AA)
15825003 (SNOMED CT 2011_0131)
MTHU003021 (LOINC Version 232)
CL381816 (UMLS CUI 2011AA)
Have serious preexisting medical conditions that, in the opinion of the investigator, that cannot be adequately controlled with appropriate therapy or would preclude participation in this study
Item
Have serious preexisting medical conditions that, in the opinion of the investigator, that cannot be adequately controlled with appropriate therapy or would preclude participation in this study
boolean
C2347662 (UMLS CUI 2011AA)
C1699700 (UMLS CUI 2011AA)
MEDCCAT (HL7 V3 2006_05)
C0205318 (UMLS CUI 2011AA)
19032002 (SNOMED CT 2011_0131)
C0039798 (UMLS CUI 2011AA)
C0332196 (UMLS CUI 2011AA)
77765009 (SNOMED CT 2011_0131)
C0679823 (UMLS CUI 2011AA)
PART (HL7 V3 2006_05)
C0008976 (UMLS CUI 2011AA)
110465008 (SNOMED CT 2011_0131)
Females who are pregnant or lactating
Item
Females who are pregnant or lactating
boolean
C0086287 (UMLS CUI 2011AA)
248152002 (SNOMED CT 2011_0131)
F (HL7 V3 2006_05)
C0549206 (UMLS CUI 2011AA)
10036586 (MedDRA 14.1)
C2828358 (UMLS CUI 2011AA)
Have a history of any other cancer (except non-melanoma skin cancer or carcinoma in-situ of the cervix) unless in complete remission and off all therapy for that disease for a minimum of 3 years
Item
Have a history of any other cancer (except non-melanoma skin cancer or carcinoma in-situ of the cervix) unless in complete remission and off all therapy for that disease for a minimum of 3 years
boolean
CL421546 (UMLS CUI 2011AA)
392521001 (SNOMED CT 2011_0131)
C0205394 (UMLS CUI 2011AA)
74964007 (SNOMED CT 2011_0131)
C0006826 (UMLS CUI 2011AA)
363346000 (SNOMED CT 2011_0131)
10028997 (MedDRA 14.1)
MTHU010328 (LOINC Version 232)
C00-C96 (ICD-10-CM Version 2010)
C1554961 (UMLS CUI 2011AA)
E (HL7 V3 2006_05)
C0699893 (UMLS CUI 2011AA)
10040810 (MedDRA 14.1)
C0851140 (UMLS CUI 2011AA)
92564006 (SNOMED CT 2011_0131)
10061809 (MedDRA 14.1)
D06.9 (ICD-10-CM Version 2010)
233.1 (ICD-9-CM Version 2011)
C1554961 (UMLS CUI 2011AA)
E (HL7 V3 2006_05)
C0677874 (UMLS CUI 2011AA)
103338009 (SNOMED CT 2011_0131)
Have active infection that would interfere with the study objectives or influence study compliance
Item
Have active infection that would interfere with the study objectives or influence study compliance
boolean
C0205177 (UMLS CUI 2011AA)
55561003 (SNOMED CT 2011_0131)
C0009450 (UMLS CUI 2011AA)
257551009 (SNOMED CT 2011_0131)
10021789 (MedDRA 14.1)
C0521102 (UMLS CUI 2011AA)
78235001 (SNOMED CT 2011_0131)
C0681832 (UMLS CUI 2011AA)
C0231347 (UMLS CUI 2011AA)
45704003 (SNOMED CT 2011_0131)