study participants
Item
meets dsm-iv criteria for dementia either sex, age 50-95 years
boolean
C0236962 (UMLS CUI [1,1])
C0497327 (UMLS CUI [1,2])
C0079399 (UMLS CUI [2])
C0001779 (UMLS CUI [3])
nincds-adrda criteria for alzheimer's disease
Item
meets nincds-adrda criteria for probable alzheimer's disease
boolean
C2828081 (UMLS CUI [1])
folstein mini-mental state examination
Item
meets folstein mini-mental state exam score of 5-26, inclusive
boolean
C0451306 (UMLS CUI [1])
intellectual impairment
Item
intellectual impairment reported for at least six months
boolean
C0683322 (UMLS CUI [1])
familiy member
Item
availability of family member who has had direct contact with the patient for an average of at least once every week during the three months prior to study entry
boolean
C0086282 (UMLS CUI [1,1])
C0332158 (UMLS CUI [1,2])
Psychosis or agitation
Item
has current symptoms of psychosis or agitation. criteria for "psychosis" requires the presence of delusions and/or hallucinations identified by the columbia university scale for psychopathology in alzheimer's disease (cuspad) and a minimum brief psychiatric rating scale (bprs) psychosis factor score of at least 4 (moderate severity) on one of the following two items: these two items comprise the psychosis factor, excluding the item for conceptual disorganization. agitation is defined as a score of greater than 3 (present at least 10 days per month) on one or more of the cerad behavioral rating scale for dementia items for agitation, purposeless wandering, verbal aggression or physical aggression.
boolean
C0011253 (UMLS CUI [1])
C0018524 (UMLS CUI [2])
C0029941 (UMLS CUI [3])
C0085631 (UMLS CUI [4])
C3887612 (UMLS CUI [5])
C0424322 (UMLS CUI [6])
C0424323 (UMLS CUI [7])
psychotropic medication
Item
free of psychotropic medication for at least two weeks prior to study entry, or able to tolerate medication washout for this period.
boolean
C0033978 (UMLS CUI [1])
informed consent
Item
informed consent by patient and family member, as per irb procedures at new york state psychiatric institute.
boolean
C0021430 (UMLS CUI [1])
Participant status
Item
acute unstable medical condition, delirium, alcohol or substance abuse or dependence within the past 1
boolean
C0184773 (UMLS CUI [1])
C0011206 (UMLS CUI [2])
C0038586 (UMLS CUI [3])
Neurological status
Item
clinical evidence of stroke, other dementias including vascular or lewy body or frontotemporal dementia, multiple sclerosis, parkinson's disease, huntington's disease, tardive dyskinesia
boolean
C0038454 (UMLS CUI [1])
C0854731 (UMLS CUI [2])
C0752347 (UMLS CUI [3])
C0338451 (UMLS CUI [4])
C0026769 (UMLS CUI [5])
C0030567 (UMLS CUI [6])
C0020179 (UMLS CUI [7])
C0686347 (UMLS CUI [8])
psychotic disorder
Item
diagnosis of a psychotic disorder antedating the onset of dementia
boolean
C0033975 (UMLS CUI [1])
antipsychotic medication
Item
antipsychotic medication usage during 4 weeks prior to study entry
boolean
C0748066 (UMLS CUI [1])
Haloperidol
Item
contraindication to the use of haloperidol
boolean
C0018546 (UMLS CUI [1,1])
C1301624 (UMLS CUI [1,2])