Liver carcinoma | Risk factors Present | Hepatitis B Virus | Hepatitis C virus | Liver Cirrhosis | Alpha one fetoprotein measurement | Feature Compatible with Liver carcinoma | CT | MRI | Angiogram | Histology
Item
hcc diagnosed as (i) the presence of risk factors including hepatitis b or c virus and liver cirrhosis, a serum a-fetoprotein (afp) level greater than 200 iu/ml and a radiologically compatible feature with hcc in one or more ct/mri/angiograms, or (ii) the presence of risk factors including hepatitis b or c virus and liver cirrhosis, a serum a-fetoprotein (afp) level less than 200 iu/ml, and a radiologically compatible feature with hcc in two or more ct/mri/angiograms or (iii) histological confirmation
boolean
C2239176 (UMLS CUI [1])
C0035648 (UMLS CUI [2,1])
C0150312 (UMLS CUI [2,2])
C0019169 (UMLS CUI [3])
C0220847 (UMLS CUI [4])
C0023890 (UMLS CUI [5])
C0201539 (UMLS CUI [6])
C2348519 (UMLS CUI [7,1])
C0332290 (UMLS CUI [7,2])
C2239176 (UMLS CUI [7,3])
C0040405 (UMLS CUI [8])
C0024485 (UMLS CUI [9])
C0002978 (UMLS CUI [10])
C0344441 (UMLS CUI [11])
Liver carcinoma Inappropriate Operative Surgical Procedures | Liver carcinoma Inappropriate Local Ablation Therapy | Operative Surgical Procedures Refused | Local Ablation Therapy Refused | Recurrent tumor | Residual Tumor | Status post Therapy
Item
hcc patients who were not prospective suitable or refused for any other treatment, such as surgery or local ablation therapy, or recurrent or residual tumor after other treatments.
boolean
C2239176 (UMLS CUI [1,1])
C1548788 (UMLS CUI [1,2])
C0543467 (UMLS CUI [1,3])
C2239176 (UMLS CUI [2,1])
C1548788 (UMLS CUI [2,2])
C0547070 (UMLS CUI [2,3])
C0543467 (UMLS CUI [3,1])
C1705116 (UMLS CUI [3,2])
C0547070 (UMLS CUI [4,1])
C1705116 (UMLS CUI [4,2])
C0521158 (UMLS CUI [5])
C0543478 (UMLS CUI [6])
C0231290 (UMLS CUI [7,1])
C0087111 (UMLS CUI [7,2])
Neoplasm Metastasis Extrahepatic Absent
Item
without evidence of extrahepatic metastasis
boolean
C0027627 (UMLS CUI [1,1])
C1517058 (UMLS CUI [1,2])
C0332197 (UMLS CUI [1,3])
Target Tumors All | Irradiation of single field Size Maximum
Item
all target tumors must be encompassable within single irradiation field (15x15 cm maximum)
boolean
C1521840 (UMLS CUI [1,1])
C0027651 (UMLS CUI [1,2])
C0444868 (UMLS CUI [1,3])
C2169158 (UMLS CUI [2,1])
C0456389 (UMLS CUI [2,2])
C0806909 (UMLS CUI [2,3])
Prior Therapy Absent Target Tumors | Prior radiation therapy Other Absent
Item
no previous treatment to target tumors by other forms of rt
boolean
C1514463 (UMLS CUI [1,1])
C0332197 (UMLS CUI [1,2])
C1521840 (UMLS CUI [1,3])
C0027651 (UMLS CUI [1,4])
C0279134 (UMLS CUI [2,1])
C0205394 (UMLS CUI [2,2])
C0332197 (UMLS CUI [2,3])
Liver function Child-Pugh Classification | Liver function Child-Pugh Score
Item
liver function of child-pugh class a or b7 (child-pugh score of ≤7)
boolean
C0232741 (UMLS CUI [1,1])
C4050412 (UMLS CUI [1,2])
C0232741 (UMLS CUI [2,1])
C4055253 (UMLS CUI [2,2])
Age
Item
age of ≥18 years
boolean
C0001779 (UMLS CUI [1])
ECOG performance status
Item
performance status of 0 to 2 on the eastern cooperative oncology group (ecog) score
boolean
C1520224 (UMLS CUI [1])
White Blood Cell Count procedure | Hemoglobin measurement | Platelet Count measurement | Liver function | Serum total bilirubin measurement | Aspartate aminotransferase measurement | Alanine aminotransferase measurement | Ascites Absent
Item
wbc count ≥ 2,000/mm3; hemoglobin level ≥ 7.5 g/dl; platelet count ≥ 25,000/mm3; and adequate hepatic function (total bilirubin ≤ 3.0 mg/dl; ast and alt < 5.0× upper limit of normal; no ascites)
boolean
C0023508 (UMLS CUI [1])
C0518015 (UMLS CUI [2])
C0032181 (UMLS CUI [3])
C0232741 (UMLS CUI [4])
C1278039 (UMLS CUI [5])
C0201899 (UMLS CUI [6])
C0201836 (UMLS CUI [7])
C0003962 (UMLS CUI [8,1])
C0332197 (UMLS CUI [8,2])
Comorbidity Serious Absent | Exception Liver Cirrhosis
Item
no serious comorbidities other than liver cirrhosis
boolean
C0009488 (UMLS CUI [1,1])
C0205404 (UMLS CUI [1,2])
C0332197 (UMLS CUI [1,3])
C1705847 (UMLS CUI [2,1])
C0023890 (UMLS CUI [2,2])
Informed Consent
Item
written informed consent
boolean
C0021430 (UMLS CUI [1])
Neoplasm Metastasis Extrahepatic
Item
evidence of extrahepatic metastasis
boolean
C0027627 (UMLS CUI [1,1])
C1517058 (UMLS CUI [1,2])
Age
Item
age < 18 years
boolean
C0001779 (UMLS CUI [1])
Liver function Child-Pugh Classification | Liver function Child-Pugh Score
Item
liver function of child-pugh class b8-9 and c (child-pugh score of >7)
boolean
C0232741 (UMLS CUI [1,1])
C4050412 (UMLS CUI [1,2])
C0232741 (UMLS CUI [2,1])
C4055253 (UMLS CUI [2,2])
Prior radiation therapy Other Target Tumors
Item
previous history of other forms of rt adjacent to target tumors
boolean
C0279134 (UMLS CUI [1,1])
C0205394 (UMLS CUI [1,2])
C1521840 (UMLS CUI [1,3])
C0027651 (UMLS CUI [1,4])
ECOG performance status
Item
poor performance status of 3 to 4 on the eastern cooperative oncology group (ecog) score
boolean
C1520224 (UMLS CUI [1])
Liver carcinoma Multicentric | Exception Liver carcinoma Multinodular | Exception Irradiation of single field Size Maximum | Exception Prior surgery Lesion | Exception Local Ablation Therapy Lesion
Item
multicentric hccs, except for those with the following two conditions: *multinodular aggregating hcc that could be encompassed by single clinical target volume and within single irradiation field (15x15 cm maximum) *lesions other than targeted tumor that were judged as controlled with prior surgery and/or local ablation therapy.
boolean
C2239176 (UMLS CUI [1,1])
C0439743 (UMLS CUI [1,2])
C1705847 (UMLS CUI [2,1])
C2239176 (UMLS CUI [2,2])
C0205416 (UMLS CUI [2,3])
C1705847 (UMLS CUI [3,1])
C2169158 (UMLS CUI [3,2])
C0456389 (UMLS CUI [3,3])
C0806909 (UMLS CUI [3,4])
C1705847 (UMLS CUI [4,1])
C0455610 (UMLS CUI [4,2])
C0221198 (UMLS CUI [4,3])
C1705847 (UMLS CUI [5,1])
C0547070 (UMLS CUI [5,2])
C0221198 (UMLS CUI [5,3])