Study Subject Inclusion criteria
Item
subjects with:
boolean
C0681850 (UMLS CUI [1,1])
C1512693 (UMLS CUI [1,2])
Primary Malignant Liver Neoplasm Advanced | Liver carcinoma Advanced
Item
confirmed advanced primary liver cancer (hepatocellular carcinoma: hcc)
boolean
C0024620 (UMLS CUI [1,1])
C0205179 (UMLS CUI [1,2])
C2239176 (UMLS CUI [2,1])
C0205179 (UMLS CUI [2,2])
Absence Systemic therapy Liver carcinoma Advanced
Item
not having received prior systemic treatment for advanced hcc
boolean
C0332197 (UMLS CUI [1,1])
C1515119 (UMLS CUI [1,2])
C2239176 (UMLS CUI [1,3])
C0205179 (UMLS CUI [1,4])
Liver function Child-Pugh Classification | Liver Dysfunction Moderate Child-Pugh Classification | Child-Pugh - Total Score
Item
normal or moderately impaired liver function (child-pugh class a or b (cp total score of ≤ 7))
boolean
C0232741 (UMLS CUI [1,1])
C4050412 (UMLS CUI [1,2])
C0086565 (UMLS CUI [2,1])
C0205081 (UMLS CUI [2,2])
C4050412 (UMLS CUI [2,3])
C4055253 (UMLS CUI [3])
ECOG performance status
Item
eastern cooperative oncology group (ecog) performance status 0 or 1
boolean
C1520224 (UMLS CUI [1])
Study Subject Exclusion Criteria
Item
subjects with:
boolean
C0681850 (UMLS CUI [1,1])
C0680251 (UMLS CUI [1,2])
Metastatic malignant neoplasm to brain | Leptomeningeal disease
Item
brain metastasis or evidence of leptomeningeal disease
boolean
C0220650 (UMLS CUI [1])
C0751297 (UMLS CUI [2])
Brain function Impaired | Encephalopathy | Heart Disease
Item
history of impaired brain function (encephalopathy) or active heart disease
boolean
C0678908 (UMLS CUI [1,1])
C0221099 (UMLS CUI [1,2])
C0085584 (UMLS CUI [2])
C0018799 (UMLS CUI [3])
Fluid-filled abdomen | Ascites
Item
unmanageable fluid in the abdomen (ascites)
boolean
C0685931 (UMLS CUI [1])
C0003962 (UMLS CUI [2])
Bleeding esophageal varices | Bleeding gastric varices
Item
bleeding esophageal or gastric varices within 2 months prior to inclusion
boolean
C0155789 (UMLS CUI [1])
C0267209 (UMLS CUI [2])