Squamous cell carcinoma of the head and neck
Item
histologically proven diagnosis of squamous cell carcinoma of the head and neck (scchn).
boolean
C1168401 (UMLS CUI [1])
HEAD NECK CANCER SQUAMOUS CELL RECURRENT Local | Squamous cell carcinoma of the head and neck unresectable | Therapeutic radiology procedure Squamous cell carcinoma of the head and neck | HEAD NECK CANCER SQUAMOUS CELL METASTATIC | Neoplasm Measurable lesion Quantity CT scan | Neoplasm Lesion FDG SUV PET/CT
Item
have either locally recurrent, unresectable, previously irradiated scchn or metastatic scchn, with at least one measurable tumor lesion (by ct scan) and at least one fdg avid (suv >/= 3, >/= 1.5 cm) tumor lesion (by pet/ct).
boolean
C4524839 (UMLS CUI [1,1])
C0205276 (UMLS CUI [1,2])
C1168401 (UMLS CUI [2,1])
C1519810 (UMLS CUI [2,2])
C1522449 (UMLS CUI [3,1])
C1168401 (UMLS CUI [3,2])
C0744620 (UMLS CUI [4])
C0027651 (UMLS CUI [5,1])
C1513041 (UMLS CUI [5,2])
C1265611 (UMLS CUI [5,3])
C0040405 (UMLS CUI [5,4])
C0027651 (UMLS CUI [6,1])
C0221198 (UMLS CUI [6,2])
C0046056 (UMLS CUI [6,3])
C2348529 (UMLS CUI [6,4])
C1699633 (UMLS CUI [6,5])
Age
Item
age greater than 18 yrs.
boolean
C0001779 (UMLS CUI [1])
ECOG performance status
Item
ecog performance status of 0-3
boolean
C1520224 (UMLS CUI [1])
Informed Consent
Item
signed irb approved informed consent.
boolean
C0021430 (UMLS CUI [1])
Interstitial Lung Disease Severe | Exception COPD | Residual volume Pulmonary function tests | Total Lung Capacity | DLCO Corrected
Item
clinical history of severe interstitial lung disease (not copd)-as defined by prior pft's with residual volume, total lung capacity, or corrected dlco <30% of predicted. for this study, screening pft's required only if clinically indicated.
boolean
C0206062 (UMLS CUI [1,1])
C0205082 (UMLS CUI [1,2])
C1705847 (UMLS CUI [2,1])
C0024117 (UMLS CUI [2,2])
C0035190 (UMLS CUI [3,1])
C0024119 (UMLS CUI [3,2])
C0040509 (UMLS CUI [4])
C1516251 (UMLS CUI [5,1])
C0205202 (UMLS CUI [5,2])
Monoclonal Antibodies EGFR Specific HEAD NECK CANCER SQUAMOUS CELL METASTATIC
Item
prior therapy with an egfr-specific monoclonal antibody (mab) for treatment of metastatic scchn. prior therapy with an egfr-specific mab as part of the definitive treatment of non-metastatic scchn is acceptable if this occurred more than three months previously. prior therapy with an egfr specific tki will not be an exclusion factor.
boolean
C0003250 (UMLS CUI [1,1])
C0034802 (UMLS CUI [1,2])
C0205369 (UMLS CUI [1,3])
C0744620 (UMLS CUI [1,4])
Childbearing Potential Pregnancy | Childbearing Potential Breast Feeding
Item
women of child bearing potential who are current pregnant or breast feeding.
boolean
C3831118 (UMLS CUI [1,1])
C0032961 (UMLS CUI [1,2])
C3831118 (UMLS CUI [2,1])
C0006147 (UMLS CUI [2,2])
Infusion reaction Severe Cetuximab | Infusion reaction CTCAE Grades
Item
prior severe (grade 4) infusion reaction to cetuximab.
boolean
C2368034 (UMLS CUI [1,1])
C0205082 (UMLS CUI [1,2])
C0995188 (UMLS CUI [1,3])
C2368034 (UMLS CUI [2,1])
C1516728 (UMLS CUI [2,2])
Disease Serious Uncontrolled | Protocol Compliance Impaired
Item
a serious uncontrolled medical disorder that in the opinion of the investigator would impair the ability of the subject to receive protocol therapy.
boolean
C0012634 (UMLS CUI [1,1])
C0205404 (UMLS CUI [1,2])
C0205318 (UMLS CUI [1,3])
C0525058 (UMLS CUI [2,1])
C0221099 (UMLS CUI [2,2])
Chemotherapy | Therapeutic radiology procedure | Investigational New Drugs
Item
chemotherapy, radiation therapy, or investigational agents given with the last 14 days.
boolean
C0392920 (UMLS CUI [1])
C1522449 (UMLS CUI [2])
C0013230 (UMLS CUI [3])
Diabetic - poor control | Fasting blood glucose measurement | Positron-Emission Tomography
Item
uncontrolled diabetes mellitus. (subjects with a fasting blood glucose > 200 at time of pet scanning may need to reschedule to another day after consulting with appropriate physicians.)
boolean
C0421258 (UMLS CUI [1])
C0428568 (UMLS CUI [2])
C0032743 (UMLS CUI [3])