Liver carcinoma
Item
1. histologically confirmed hcc (or fulfilling aasld criteria for hcc diagnosis in hbsag positive subjects with cirrhosis in case biopsy is not feasible)
boolean
C2239176 (UMLS CUI [1])
Disease Inappropriate Curative Surgery
Item
2. disease must not be amenable to potentially curative surgery
boolean
C0012634 (UMLS CUI [1,1])
C1548788 (UMLS CUI [1,2])
C1511562 (UMLS CUI [1,3])
Systemic therapy Absent | Therapy Arterial Absent
Item
3. without prior systemic nor transarterial treatment
boolean
C1515119 (UMLS CUI [1,1])
C0332197 (UMLS CUI [1,2])
C0087111 (UMLS CUI [2,1])
C0221464 (UMLS CUI [2,2])
C0332197 (UMLS CUI [2,3])
Operative Surgical Procedures | Local Therapy | Target Lesion untreated
Item
4. prior surgery or local therapy is allowed but the target lesion must have not been previously treated
boolean
C0543467 (UMLS CUI [1])
C1517925 (UMLS CUI [2])
C2986546 (UMLS CUI [3,1])
C0332155 (UMLS CUI [3,2])
Liver function Child-Pugh Classification
Item
5. child-pugh stage a liver function
boolean
C0232741 (UMLS CUI [1,1])
C4050412 (UMLS CUI [1,2])
ECOG performance status
Item
6. ecog performance 0-2
boolean
C1520224 (UMLS CUI [1])
Life Expectancy
Item
7. life expectancy longer than 12 weeks
boolean
C0023671 (UMLS CUI [1])
Therapy Measurable lesion Quantity
Item
8. at least one measurable treatment lesion according to modified recist criteria
boolean
C0087111 (UMLS CUI [1,1])
C1513041 (UMLS CUI [1,2])
C1265611 (UMLS CUI [1,3])
Hematologic function | Liver function | Renal function
Item
9. adequate haematological, hepatic and renal function
boolean
C0221130 (UMLS CUI [1])
C0232741 (UMLS CUI [2])
C0232804 (UMLS CUI [3])
Medical contraindication Transarterial Chemoembolization
Item
1. contra-indications to tace treatment:
boolean
C1301624 (UMLS CUI [1,1])
C3539919 (UMLS CUI [1,2])
Main portal vein Thrombosis | Main portal vein Occlusion
Item
main portal vein thrombosis or occlusion
boolean
C1183135 (UMLS CUI [1,1])
C0040053 (UMLS CUI [1,2])
C1183135 (UMLS CUI [2,1])
C0028778 (UMLS CUI [2,2])
Obstruction of biliary tree
Item
evidence of biliary obstruction
boolean
C0400979 (UMLS CUI [1])
Disease Extrahepatic
Item
presence of extra-hepatic disease
boolean
C0012634 (UMLS CUI [1,1])
C1517058 (UMLS CUI [1,2])
Liver carcinoma Type Diffuse
Item
2. diffuse-type hcc
boolean
C2239176 (UMLS CUI [1,1])
C0332307 (UMLS CUI [1,2])
C0205219 (UMLS CUI [1,3])
Major surgery | Therapeutic radiology procedure
Item
3. major surgery <4 weeks or radiation therapy <2 weeks of starting the study treatment.
boolean
C0679637 (UMLS CUI [1])
C1522449 (UMLS CUI [2])
Therapy Arterial Liver carcinoma | Systemic therapy Liver carcinoma
Item
4. any form of prior transarterial therapy or systemic therapy for hcc.
boolean
C0087111 (UMLS CUI [1,1])
C0221464 (UMLS CUI [1,2])
C2239176 (UMLS CUI [1,3])
C1515119 (UMLS CUI [2,1])
C2239176 (UMLS CUI [2,2])
CYP3A4 Inhibitors Strong | CYP3A4 Inducers Strong | CYP1A2 Inducers Strong | Patient need for CYP3A4 Inhibitors Strong | Patient need for CYP3A4 Inducers Strong | Patient need for CYP1A2 Inducers Strong
Item
5. current use or anticipated need for treatment with drugs that are known potent cyp3a4 inhibitors or cyp3a4 or cyp1a2 inducers.
boolean
C3850053 (UMLS CUI [1,1])
C0442821 (UMLS CUI [1,2])
C3850041 (UMLS CUI [2,1])
C0442821 (UMLS CUI [2,2])
C3850050 (UMLS CUI [3,1])
C0442821 (UMLS CUI [3,2])
C0686904 (UMLS CUI [4,1])
C3850053 (UMLS CUI [4,2])
C0442821 (UMLS CUI [4,3])
C0686904 (UMLS CUI [5,1])
C3850041 (UMLS CUI [5,2])
C0442821 (UMLS CUI [5,3])
C0686904 (UMLS CUI [6,1])
C3850050 (UMLS CUI [6,2])
C0442821 (UMLS CUI [6,3])
Requirement Anticoagulant therapy | Requirement Vitamin K antagonists Oral | Low Molecular Weight Heparin allowed
Item
6. requirement of anticoagulant therapy with oral vitamin k antagonists. low dose anticoagulants for maintenance of patency of central venous access devise or prevention of deep venous thrombosis is allowed. therapeutic use of low molecular weight heparin is allowed.
boolean
C1514873 (UMLS CUI [1,1])
C0150457 (UMLS CUI [1,2])
C1514873 (UMLS CUI [2,1])
C3653316 (UMLS CUI [2,2])
C1527415 (UMLS CUI [2,3])
C0019139 (UMLS CUI [3,1])
C0683607 (UMLS CUI [3,2])
Hemorrhage CTCAE Grades
Item
7. any haemorrhage or bleeding event of ctcae grade 3 or more within 4 week
boolean
C0019080 (UMLS CUI [1,1])
C1516728 (UMLS CUI [1,2])