Liver carcinoma
Item
histologically diagnosed hcc, or clinically diagnosed hcc
boolean
C2239176 (UMLS CUI [1])
Tumor Inoperable | Curative treatment Unsuccessful | Tumor Inappropriate Therapy Local-Regional
Item
inoperable tumor(s) and no applicable curative therapy. not amenable to loco-regional therapy
boolean
C0027651 (UMLS CUI [1,1])
C0205187 (UMLS CUI [1,2])
C1273390 (UMLS CUI [2,1])
C1272705 (UMLS CUI [2,2])
C0027651 (UMLS CUI [3,1])
C1548788 (UMLS CUI [3,2])
C0087111 (UMLS CUI [3,3])
C1947913 (UMLS CUI [3,4])
sorafenib | Disease Progression | Intolerance to Sorafenib | First line treatment Liver carcinoma Advanced
Item
documented progression with or intolerance to sorafenib treatment as first- line therapy for advanced hcc
boolean
C1516119 (UMLS CUI [1])
C0242656 (UMLS CUI [2])
C1744706 (UMLS CUI [3,1])
C1516119 (UMLS CUI [3,2])
C1708063 (UMLS CUI [4,1])
C2239176 (UMLS CUI [4,2])
C0205179 (UMLS CUI [4,3])
Measurable Disease Quantity | Local Therapy Absent
Item
at least one measurable tumor, according to recist version 1.1, that has not been treated with any local procedure
boolean
C1513041 (UMLS CUI [1,1])
C1265611 (UMLS CUI [1,2])
C1517925 (UMLS CUI [2,1])
C0332197 (UMLS CUI [2,2])
ECOG performance status
Item
ecog performance status 0 or 1
boolean
C1520224 (UMLS CUI [1])
Life Expectancy
Item
life expectancy is at least 2 months
boolean
C0023671 (UMLS CUI [1])
Liver function Child-Pugh Classification
Item
child-pugh class a liver function.
boolean
C0232741 (UMLS CUI [1,1])
C4050412 (UMLS CUI [1,2])
Systemic therapy Except Sorafenib | First line treatment Liver carcinoma Advanced
Item
systemic therapy other than sorafenib as first-line therapy for advanced hcc
boolean
C1515119 (UMLS CUI [1,1])
C0332300 (UMLS CUI [1,2])
C1516119 (UMLS CUI [1,3])
C1708063 (UMLS CUI [2,1])
C2239176 (UMLS CUI [2,2])
C0205179 (UMLS CUI [2,3])
Liver carcinoma Tumour rupture
Item
history of hcc tumor rupture
boolean
C2239176 (UMLS CUI [1,1])
C2938957 (UMLS CUI [1,2])
Metastatic malignant neoplasm to brain | Metastatic Malignant Neoplasm to the Leptomeninges
Item
presence of brain or leptomeningeal metastases
boolean
C0220650 (UMLS CUI [1])
C1704231 (UMLS CUI [2])
Esophageal Varices | Gastric Varices | Peptic Ulcer | High risk of bleeding
Item
esophageal/gastric varices or active peptic ulcers that are considered to have high risk of bleeding
boolean
C0014867 (UMLS CUI [1])
C0017145 (UMLS CUI [2])
C0030920 (UMLS CUI [3])
C4039184 (UMLS CUI [4])
Upper gastrointestinal hemorrhage
Item
history of upper gastrointestinal bleeding within 1 year
boolean
C0041909 (UMLS CUI [1])
Systemic disease Major | Study Subject Participation Status Inappropriate
Item
major systemic diseases that the investigator considers inappropriate for participation
boolean
C0442893 (UMLS CUI [1,1])
C0205164 (UMLS CUI [1,2])
C2348568 (UMLS CUI [2,1])
C1548788 (UMLS CUI [2,2])
Uncontrolled hypertension
Item
uncontrollable hypertension
boolean
C1868885 (UMLS CUI [1])
Proteinuria
Item
proteinuria
boolean
C0033687 (UMLS CUI [1])
CYP3A4 Inhibitor Strong | CYP3A4 Inducers Strong | CYP1A2 Inducers Strong | Patient need for CYP3A4 Inhibitor Strong | Patient need for CYP3A4 Inducers Strong | Patient need for CYP1A2 Inducers Strong
Item
current use or anticipated need for treatment with potent cyp3a4 inhibitor, cyp3a4 or cyp1a2 inducers
boolean
C3830624 (UMLS CUI [1,1])
C0442821 (UMLS CUI [1,2])
C3850041 (UMLS CUI [2,1])
C0442821 (UMLS CUI [2,2])
C3850050 (UMLS CUI [3,1])
C0442821 (UMLS CUI [3,2])
C0686904 (UMLS CUI [4,1])
C3830624 (UMLS CUI [4,2])
C0442821 (UMLS CUI [4,3])
C0686904 (UMLS CUI [5,1])
C3850041 (UMLS CUI [5,2])
C0442821 (UMLS CUI [5,3])
C0686904 (UMLS CUI [6,1])
C3850050 (UMLS CUI [6,2])
C0442821 (UMLS CUI [6,3])
Requirement Anticoagulant therapy | Requirement Vitamin K antagonists Oral
Item
requirement of anticoagulant therapy with oral vitamin k antagonists
boolean
C1514873 (UMLS CUI [1,1])
C0150457 (UMLS CUI [1,2])
C1514873 (UMLS CUI [2,1])
C3653316 (UMLS CUI [2,2])
C1527415 (UMLS CUI [2,3])
Dementia Preventing Informed Consent | Altered mental state Preventing Informed Consent | Dementia Preventing Protocol Compliance | Altered mental state Preventing Protocol Compliance
Item
dementia or significantly altered mental status that would prohibit the understanding or rendering of informed consent and compliance with the requirements of this protocol
boolean
C0497327 (UMLS CUI [1,1])
C1292733 (UMLS CUI [1,2])
C0021430 (UMLS CUI [1,3])
C0278061 (UMLS CUI [2,1])
C1292733 (UMLS CUI [2,2])
C0021430 (UMLS CUI [2,3])
C0497327 (UMLS CUI [3,1])
C1292733 (UMLS CUI [3,2])
C0525058 (UMLS CUI [3,3])
C0278061 (UMLS CUI [4,1])
C1292733 (UMLS CUI [4,2])
C0525058 (UMLS CUI [4,3])
Medical condition Study Subject Participation Status At risk | Chronic disease Study Subject Participation Status At risk | Mental disorders Study Subject Participation Status At risk | Chronic mental disorder Study Subject Participation Status At risk | Laboratory test result abnormal Study Subject Participation Status At risk | Medical condition Study Subject Participation Status Inappropriate | Chronic disease Study Subject Participation Status Inappropriate | Mental disorders Study Subject Participation Status Inappropriate | Chronic mental disorder Study Subject Participation Status Inappropriate | Laboratory test result abnormal Study Subject Participation Status Inappropriate
Item
other severe acute or chronic medical or psychiatric condition, or laboratory abnormality that may increase the risk associated with study participation and in the judgment of the investigator would make the patient inappropriate for entry into this study
boolean
C3843040 (UMLS CUI [1,1])
C2348568 (UMLS CUI [1,2])
C1444641 (UMLS CUI [1,3])
C0008679 (UMLS CUI [2,1])
C2348568 (UMLS CUI [2,2])
C1444641 (UMLS CUI [2,3])
C0004936 (UMLS CUI [3,1])
C2348568 (UMLS CUI [3,2])
C1444641 (UMLS CUI [3,3])
C0870281 (UMLS CUI [4,1])
C2348568 (UMLS CUI [4,2])
C1444641 (UMLS CUI [4,3])
C0438215 (UMLS CUI [5,1])
C2348568 (UMLS CUI [5,2])
C1444641 (UMLS CUI [5,3])
C3843040 (UMLS CUI [6,1])
C2348568 (UMLS CUI [6,2])
C1548788 (UMLS CUI [6,3])
C0008679 (UMLS CUI [7,1])
C2348568 (UMLS CUI [7,2])
C1548788 (UMLS CUI [7,3])
C0004936 (UMLS CUI [8,1])
C2348568 (UMLS CUI [8,2])
C1548788 (UMLS CUI [8,3])
C0870281 (UMLS CUI [9,1])
C2348568 (UMLS CUI [9,2])
C1548788 (UMLS CUI [9,3])
C0438215 (UMLS CUI [10,1])
C2348568 (UMLS CUI [10,2])
C1548788 (UMLS CUI [10,3])