Gender | Age | Compliance behavior
Item
1. males/females between 18 and 65 years of age who are capable of understanding and complying with the protocol (ie. have completed at least a 9th grade education and are fluent english).
boolean
C0079399 (UMLS CUI [1])
C0001779 (UMLS CUI [2])
C1321605 (UMLS CUI [3])
Relapsing remitting ms (rrms) | Secondary progressive ms (spms)
Item
2. have a diagnosis of relapsing remitting ms (rrms) or early secondary progressive ms (spms) as per revised mcdonald's criteria.
boolean
C0751967 (UMLS CUI [1,1])
C0679228 (UMLS CUI [1,2])
C0751965 (UMLS CUI [2,1])
C0679228 (UMLS CUI [2,2])
Kurtzke multiple sclerosis rating scale
Item
3. have an expanded disability severity scale (edss) of ≤ 7.0.
boolean
C0451246 (UMLS CUI [1])
Valid neuropsychological testing (np)
Item
4. have had valid neuropsychological testing (np) within the past 4 years
boolean
C0027902 (UMLS CUI [1,1])
C2349101 (UMLS CUI [1,2])
Cognitive symptom of recent origin | Supratentorial gad enhancing lesions on mri with confirmed cognitive decline
Item
5. experiencing an acute cognitive relapse identified by a clinical care provider as a.) a cognitive symptom of recent origin developing over 48 hours, or b.) supratentorial gad enhancing lesions on mri with confirmed cognitive decline.
boolean
C0338656 (UMLS CUI [1,1])
C0332185 (UMLS CUI [1,2])
C1333400 (UMLS CUI [2,1])
C0441938 (UMLS CUI [2,2])
C0234985 (UMLS CUI [2,3])
Symbol digit modalities test (sdmt) at screening | Symbol digit modalities test (sdmt) in the past
Item
confirmation of cognitive decline will be obtained by administering the symbol digit modalities test (sdmt) as a screening procedure for the study and comparing it to scores obtained within 4 years (see inclusion criteria #4). participants qualify if a raw point change on the sdmt greater than or equal to-3 points is detected.
boolean
C0814254 (UMLS CUI [1,1])
C0220908 (UMLS CUI [1,2])
C0814254 (UMLS CUI [1,3])
C1444637 (UMLS CUI [1,4])
C1707455 (UMLS CUI [1,5])
Capable of neuropsychological (np) testing including near visual acuity
Item
6. are capable of performing the requirements of neuropsychological (np) testing, including near visual acuity 20/70 or better with correction.
boolean
C0027902 (UMLS CUI [1,1])
C0429541 (UMLS CUI [1,2])
C0332257 (UMLS CUI [1,3])
Informed consent
Item
7. have given written informed consent prior to any study-related procedure not part of normal medical care, with the understanding that consent may be withdrawn by the subject at any time without prejudice to his/her future medical care.
boolean
C0021430 (UMLS CUI [1])
Evidence of new lesions in the brainstem, spinal cord, or optic nerve on mri
Item
1. are found to have evidence on mri of new lesions in the brainstem, spinal cord, or optic nerve.
boolean
C0221198 (UMLS CUI [1,1])
C0205314 (UMLS CUI [1,2])
C0006121 (UMLS CUI [1,3])
C0024485 (UMLS CUI [1,4])
C0221198 (UMLS CUI [2,1])
C0205314 (UMLS CUI [2,2])
C0037925 (UMLS CUI [2,3])
C0024485 (UMLS CUI [2,4])
C0221198 (UMLS CUI [3,1])
C0205314 (UMLS CUI [3,2])
C0029130 (UMLS CUI [3,3])
C0024485 (UMLS CUI [3,4])
New physical signs or symptoms that are referable to the cord, brainstem or optic nerve
Item
2. have clear new physical signs or symptoms that are referable to the cord, brainstem or optic nerve.
boolean
C0037088 (UMLS CUI [1,1])
C0205314 (UMLS CUI [1,2])
C0006121 (UMLS CUI [1,3])
C0037088 (UMLS CUI [2,1])
C0205314 (UMLS CUI [2,2])
C0037925 (UMLS CUI [2,3])
C0037088 (UMLS CUI [3,1])
C0205314 (UMLS CUI [3,2])
C0029130 (UMLS CUI [3,3])
Impaired cognition caused by concomitant medication usage | Significant comorbidity | Significant nervous system disorder | Significant mental disorder
Item
3. have cognitive deficits/impairment caused by concomitant medication usage, or are attributable to another medical condition or significant neurological/psychological disease.
boolean
C0338656 (UMLS CUI [1,1])
C2347852 (UMLS CUI [1,2])
C0678226 (UMLS CUI [1,3])
C0009488 (UMLS CUI [2,1])
C0750502 (UMLS CUI [2,2])
C0027765 (UMLS CUI [3,1])
C0750502 (UMLS CUI [3,2])
C0004936 (UMLS CUI [4,1])
C0750502 (UMLS CUI [4,2])
Current major depression as determined by a positive beck depression inventory-fast screen (bdi-fs) and clinician interview.
Item
4. have evidence of current major depression as determined by a positive beck depression inventory-fast screen (bdi-fs) and clinician interview.
boolean
C1269683 (UMLS CUI [1,1])
C0521116 (UMLS CUI [1,2])
C0451022 (UMLS CUI [1,3])
C0021822 (UMLS CUI [1,4])
Recent changes to medications known to influence cognition | Recent changes to disease modifying therapy
Item
5. patients with changes to medications known to influence cognition (narcotics, stimulants, etc.) or disease modifying therapy within one month of study initiation (or within a time frame deemed high risk by treating physician) will be excluded.
boolean
C0580105 (UMLS CUI [1,1])
C0009240 (UMLS CUI [1,2])
C4054723 (UMLS CUI [1,3])
C0332185 (UMLS CUI [1,4])
C0087111 (UMLS CUI [2,1])
C0012634 (UMLS CUI [2,2])
C0392747 (UMLS CUI [2,3])
C0332185 (UMLS CUI [2,4])
Concomitant agent contraindicated with acthar | Comorbidity contraindicated with acthar
Item
6. are taking any medication, or have any medical condition contraindicated with acthar.
boolean
C2347852 (UMLS CUI [1,1])
C1301624 (UMLS CUI [1,2])
C0718234 (UMLS CUI [1,3])
C0009488 (UMLS CUI [2,1])
C1301624 (UMLS CUI [2,2])
C0718234 (UMLS CUI [2,3])
Communicable Diseases
Item
7. presence of current infections as determined by clinician interview.
boolean
C0009450 (UMLS CUI [1])
Breast Feeding | Planned pregnancy | Childbearing potential
Item
8. are currently nursing, intentionally seeking pregnancy, or deemed at-risk for unplanned pregnancy.
boolean
C0006147 (UMLS CUI [1])
C0032992 (UMLS CUI [2])
C3831118 (UMLS CUI [3])