Age
Item
adult patients; >/= 18 years of age
boolean
C0001779 (UMLS CUI [1])
ECOG performance status
Item
eastern cooperative oncology group (ecog) performance status 0, 1, or 2
boolean
C1520224 (UMLS CUI [1])
Relapsed multiple myeloma | Refractory multiple myeloma
Item
relapsed or refractory multiple myeloma for which no effective standard therapy exists
boolean
C1370446 (UMLS CUI [1])
C0278620 (UMLS CUI [2])
Prior therapy with a proteasome inhibitor | Prior therapy with an immunomodulatory drug
Item
one of the prior therapies must have included a proteosome inhibitor or an immunomodulatory drug
boolean
C1443643 (UMLS CUI [1,1])
C1514463 (UMLS CUI [1,2])
C1963758 (UMLS CUI [2,1])
C1514463 (UMLS CUI [2,2])
Measurable disease as defined by protocol
Item
measurable disease as defined by protocol
boolean
C1513041 (UMLS CUI [1,1])
C2348563 (UMLS CUI [1,2])
Recent use of monoclonal antibody
Item
prior use of monoclonal antibody within 4 weeks before cycle 1, day 1
boolean
C0003250 (UMLS CUI [1,1])
C0332185 (UMLS CUI [1,2])
Recent Radiotherapy | Thalidomide | Lenalidomide | Bortezomib | Chemotheraphy | Any investigational anti-cancer agent
Item
treatment with radiotherapy, thalidomide, lenalidomide, bortezomib, any chemotherapeutic agent, or treatment with any investigational anti-cancer agent within 2 weeks prior to cycle 1, day 1
boolean
C1522449 (UMLS CUI [1,1])
C0332185 (UMLS CUI [1,2])
C0039736 (UMLS CUI [2,1])
C0332185 (UMLS CUI [2,2])
C1144149 (UMLS CUI [3,1])
C0332185 (UMLS CUI [3,2])
C1176309 (UMLS CUI [4,1])
C0332185 (UMLS CUI [4,2])
C0392920 (UMLS CUI [5,1])
C0332185 (UMLS CUI [5,2])
C0920425 (UMLS CUI [6,1])
C0013230 (UMLS CUI [6,2])
C0332185 (UMLS CUI [6,3])
Toxicities from any previous treatment (except neuropathy) must be resolved
Item
toxicities from any previous treatment must be resolved prior to cycle 1, day 1, except for neuropathy
boolean
C0600688 (UMLS CUI [1,1])
C0678226 (UMLS CUI [1,2])
C1514463 (UMLS CUI [1,3])
C1514893 (UMLS CUI [1,4])
C0442874 (UMLS CUI [1,5])
C1705847 (UMLS CUI [1,6])
Transplantation of autologous hematopoietic stem cell
Item
completion of autologous stem cell transplant within 100 days prior to cycle 1, day 1
boolean
C1831743 (UMLS CUI [1])
Allogeneic Stem Cell Transplantation
Item
prior allogeneic stem cell transplant
boolean
C2242529 (UMLS CUI [1])
History of severe allergic or anaphylactic reactions to monoclonal antibody therapy | History of severe allergic or anaphylactic reactions to recombinant antibody-related fusion proteins
Item
history of severe allergic or anaphylactic reactions to monoclonal antibody therapy (or recombinant antibody-related fusion proteins)
boolean
C0003250 (UMLS CUI [1,1])
C0020517 (UMLS CUI [1,2])
C0205082 (UMLS CUI [1,3])
C0262926 (UMLS CUI [1,4])
C0003250 (UMLS CUI [2,1])
C0002792 (UMLS CUI [2,2])
C0205082 (UMLS CUI [2,3])
C0262926 (UMLS CUI [2,4])
C0003250 (UMLS CUI [3,1])
C0034861 (UMLS CUI [3,2])
C0020517 (UMLS CUI [3,3])
C0205082 (UMLS CUI [3,4])
C0262926 (UMLS CUI [3,5])
C0003250 (UMLS CUI [4,1])
C0034861 (UMLS CUI [4,2])
C0002792 (UMLS CUI [4,3])
C0205082 (UMLS CUI [4,4])
C0262926 (UMLS CUI [4,5])
Grade of peripheral neuropathy
Item
grade > 1 peripheral neuropathy
boolean
C0031117 (UMLS CUI [1,1])
C0441800 (UMLS CUI [1,2])
Active infection | Recent episode of an infection requiring treatment with iv antibiotics or hospitalization
Item
active infection at screening or any major episode of infection requiring treatment with iv antibiotics or hospitalization within 4 weeks prior to cycle 1, day 1
boolean
C0009450 (UMLS CUI [1,1])
C0205177 (UMLS CUI [1,2])
C0009450 (UMLS CUI [2,1])
C1514873 (UMLS CUI [2,2])
C0559680 (UMLS CUI [2,3])
C0332185 (UMLS CUI [2,4])
C0009450 (UMLS CUI [3,1])
C1514873 (UMLS CUI [3,2])
C0019993 (UMLS CUI [3,3])
C0332185 (UMLS CUI [3,4])
Hepatitis B positive | Hepatitis C positive | HIV seropositivity
Item
positive for hepatitis b, hepatitis c or hiv infection
boolean
C0019163 (UMLS CUI [1,1])
C1446409 (UMLS CUI [1,2])
C0019196 (UMLS CUI [2,1])
C1446409 (UMLS CUI [2,2])
C0019699 (UMLS CUI [3])
Pregnancy | Breast Feeding | Pregnancy planned
Item
pregnant or lactating women or women who intend to become pregnant within the period of time of this study
boolean
C0032961 (UMLS CUI [1])
C0006147 (UMLS CUI [2])
C0032992 (UMLS CUI [3])