Type 2 diabetes and Chronic Kidney Diseases
Item
1. patients with type 2 diabetes and ckd
boolean
C0011860 (UMLS CUI [1,1])
C1561643 (UMLS CUI [1,2])
Age
Item
2. age 18 - 70 years
boolean
C0001779 (UMLS CUI [1])
Stable anti-hypertensive therapy | Stable lipid lowering therapy | ACEi | ARB
Item
3. stable anti-hypertensive and lipid lowering therapy for at least 2 months. all patients should be on an acei or arb unless contraindicated because of side effects (standard of care). no changes in lipid lowering therapy during the 3 months of this study. blood pressure doses may be changed but new therapy with ace inhibitors will not be allowed.
boolean
C0585941 (UMLS CUI [1,1])
C0205360 (UMLS CUI [1,2])
C0585943 (UMLS CUI [2,1])
C0205360 (UMLS CUI [2,2])
C0003015 (UMLS CUI [3])
C0521942 (UMLS CUI [4])
Severe comorbidity
Item
1. severe co morbid conditions - e.g. cancer, etc.
boolean
C0009488 (UMLS CUI [1,1])
C0205082 (UMLS CUI [1,2])
Congestive heart failure
Item
2. congestive heart failure.
boolean
C0018802 (UMLS CUI [1])
Unable to give an informed consent | Unable to attend study related visits
Item
3. inability to give informed consent or attend study related visits.
boolean
C0021430 (UMLS CUI [1,1])
C1299582 (UMLS CUI [1,2])
C0008952 (UMLS CUI [2,1])
C1299582 (UMLS CUI [2,2])
Medical history of an abnormally high vitamin d or calcium levels
Item
4. have a history of abnormally high vitamin d or calcium levels in the bloodstream.
boolean
C0262926 (UMLS CUI [1,1])
C0919758 (UMLS CUI [1,2])
C0438215 (UMLS CUI [1,3])
C0442805 (UMLS CUI [1,4])
C0262926 (UMLS CUI [2,1])
C0201925 (UMLS CUI [2,2])
C0438215 (UMLS CUI [2,3])
C0442805 (UMLS CUI [2,4])
Protocol compliance unable | Protocol compliance unwilling
Item
5. unwilling or unable to complete screening or data collection procedures.
boolean
C0525058 (UMLS CUI [1,1])
C1299582 (UMLS CUI [1,2])
C0525058 (UMLS CUI [2,1])
C0558080 (UMLS CUI [2,2])
A known allergy to the study drug
Item
6. have a known allergy to the study drug.
boolean
C0020517 (UMLS CUI [1,1])
C0013230 (UMLS CUI [1,2])
Pregnancy | Breast Feeding
Item
7. pregnant or breast feeding
boolean
C0032961 (UMLS CUI [1])
C0006147 (UMLS CUI [2])
Calcium measurement
Item
8. plasma calcium >9 mg/dl
boolean
C0201925 (UMLS CUI [1])
Calcium supplementation
Item
9. patients should discontinue any calcium supplementation prior to entry into the study.
boolean
C1096745 (UMLS CUI [1])
Vitamin D supplement therapy
Item
10. other vitamin d analogs (eg sensipar) and vitamin d preparations are contraindicated
boolean
C0420176 (UMLS CUI [1,1])
C0205394 (UMLS CUI [1,2])