Karnofsky performance status
Item
kps 60%
boolean
C0206065 (UMLS CUI [1])
Urothelial carcinoma with metastatic disease
Item
histological confirmation of urothelial carcinoma , with metastatic disease
boolean
C0007138 (UMLS CUI [1,1])
C0027627 (UMLS CUI [1,2])
Measurable disease
Item
measurable disease
boolean
C1513041 (UMLS CUI [1])
Prior therapy with platinum-based chemotherapy
Item
previously treated with platinum-based chemotherapy administered
boolean
C1514463 (UMLS CUI [1,1])
C0392920 (UMLS CUI [1,2])
C1514162 (UMLS CUI [1,3])
Radiographic evidence of cavitary tumours | Radiographic evidence of necrotic tumours
Item
radiographic evidence of cavitary or necrotic tumours
boolean
C4524108 (UMLS CUI [1,1])
C1962945 (UMLS CUI [1,2])
C0332120 (UMLS CUI [1,3])
C1300818 (UMLS CUI [2,1])
C1962945 (UMLS CUI [2,2])
C0332120 (UMLS CUI [2,3])
Active brain metastasis | Leptomeningeal metastasis
Item
active brain metastasis.leptomeningeal metastasis
boolean
C0220650 (UMLS CUI [1,1])
C0205177 (UMLS CUI [1,2])
C1704231 (UMLS CUI [2])
Chemotherapy | Radiotherapy | Targeted therapy with monoclonal antibodies | Targeted therapy with small tyrosine kinase inhibitors
Item
chemotherapy, radiotherapy, targeted therapy with monoclonal antibodies or small tyrosine kinase inhibitors
boolean
C0392920 (UMLS CUI [1])
C1522449 (UMLS CUI [2])
C2985566 (UMLS CUI [3,1])
C0003250 (UMLS CUI [3,2])
C2985566 (UMLS CUI [4,1])
C0879484 (UMLS CUI [4,2])
Toxicity grade from previous chemotherapy, radiotherapy, or targeted therapy
Item
grade 1 treatment-related toxicity from previous chemotherapy, radiotherapy, or targeted therapy
boolean
C0392920 (UMLS CUI [1,1])
C2826262 (UMLS CUI [1,2])
C1522449 (UMLS CUI [2,1])
C2826262 (UMLS CUI [2,2])
C2985566 (UMLS CUI [3,1])
C2826262 (UMLS CUI [3,2])
Prior treatment with bibf 1120 or other vegfr inhibitors
Item
prior treatment with bibf 1120 or other vegfr inhibitors
boolean
C2930789 (UMLS CUI [1,1])
C1514463 (UMLS CUI [1,2])
C2985521 (UMLS CUI [2,1])
C0205394 (UMLS CUI [2,2])
C1514463 (UMLS CUI [2,3])
Significant cardiovascular diseases
Item
significant cardiovascular diseases:
boolean
C0007222 (UMLS CUI [1,1])
C0750502 (UMLS CUI [1,2])
Pericardial effusion
Item
pericardial effusion
boolean
C0031039 (UMLS CUI [1])
Significant bleeding | Significant thrombosis
Item
significant bleeding or thrombosis
boolean
C0019080 (UMLS CUI [1,1])
C0750502 (UMLS CUI [1,2])
C0040053 (UMLS CUI [2,1])
C0750502 (UMLS CUI [2,2])
Gastrointestinal disorders or abnormalities that would interfere with absorption of the study drug
Item
gastrointestinal disorders or abnormalities that would interfere with absorption of the study drug
boolean
C0017178 (UMLS CUI [1,1])
C0521102 (UMLS CUI [1,2])
C0237442 (UMLS CUI [1,3])
C0013230 (UMLS CUI [1,4])
C4023588 (UMLS CUI [2,1])
C0521102 (UMLS CUI [2,2])
C0237442 (UMLS CUI [2,3])
C0013230 (UMLS CUI [2,4])
Recent major injuries with incomplete wound healing | Planned surgery during the on-treatment study period
Item
major injuries within the past 10 days with incomplete wound healing and/or planned surgery during the on-treatment study period
boolean
C0332677 (UMLS CUI [1,1])
C0151692 (UMLS CUI [1,2])
C0332185 (UMLS CUI [1,3])
C0543467 (UMLS CUI [2,1])
C1301732 (UMLS CUI [2,2])
C2347804 (UMLS CUI [2,3])