Age | Informed Consent
Item
patient at least 18 years of age with written informed consent prior to enrollment into the study.
boolean
C0001779 (UMLS CUI [1])
C0021430 (UMLS CUI [2])
Advanced Adult Hepatocellular Carcinoma unresectable | Metastatic hepatocellular carcinoma
Item
histologically or cytologically confirmed advanced unresectable and/or metastasis) hcc
boolean
C1706732 (UMLS CUI [1,1])
C1519810 (UMLS CUI [1,2])
C0744869 (UMLS CUI [2])
Child-Pugh Classification
Item
child-pugh class a or b
boolean
C4050412 (UMLS CUI [1])
Measurable Disease
Item
have measurable disease according to recist criteria
boolean
C1513041 (UMLS CUI [1])
Life Expectancy | ECOG performance status
Item
life expectancy of at least 12 weeks, ecog 0-2
boolean
C0023671 (UMLS CUI [1])
C1520224 (UMLS CUI [2])
Bone Marrow Mature Neutrophils Present Complete | Liver function | Renal function
Item
have adequate bone marrow reserve and liver and renal function at screening
boolean
C0005953 (UMLS CUI [1,1])
C1708947 (UMLS CUI [1,2])
C0205197 (UMLS CUI [1,3])
C0232741 (UMLS CUI [2])
C0232804 (UMLS CUI [3])
Contraceptive methods
Item
practice adequate contraception during study participation
boolean
C0700589 (UMLS CUI [1])
Heart Diseases | HIV Infection | Communicable Disease | Metastatic malignant neoplasm to brain | Neoplasm Metastasis Intracranial | Epilepsy Requirement Pharmaceutical Preparations | Organ Allograft | Bleeding tendency | Primary tumor site Different | Malignant Neoplasm Histology Different | Exception Carcinoma in situ of uterine cervix | Exception Basal cell carcinoma Treated
Item
exclude medical conditions including history of cardiac disease, hiv infection,active infection,brain metastastasis or intracranial metastasis,seizure disorder requiring medication, history of organ allograft,evidence of or history of bleeding diathesis,previous or concurrent cancer with distinct in primary site or histology (with exception of cervical carcinoma in situ and treated basal cell carcinoma
boolean
C0018799 (UMLS CUI [1])
C0019693 (UMLS CUI [2])
C0009450 (UMLS CUI [3])
C0220650 (UMLS CUI [4])
C0027627 (UMLS CUI [5,1])
C0524466 (UMLS CUI [5,2])
C0014544 (UMLS CUI [6,1])
C1514873 (UMLS CUI [6,2])
C0013227 (UMLS CUI [6,3])
C0178784 (UMLS CUI [7,1])
C0040739 (UMLS CUI [7,2])
C1458140 (UMLS CUI [8])
C0475447 (UMLS CUI [9,1])
C1705242 (UMLS CUI [9,2])
C0006826 (UMLS CUI [10,1])
C4048239 (UMLS CUI [10,2])
C1705242 (UMLS CUI [10,3])
C1705847 (UMLS CUI [11,1])
C0851140 (UMLS CUI [11,2])
C1705847 (UMLS CUI [12,1])
C0007117 (UMLS CUI [12,2])
C1522326 (UMLS CUI [12,3])
Systemic Chemotherapy Malignant Neoplasms | Immunotherapy | Targeted Therapy | Hormone Therapy | Local Therapy | Therapeutic radiology procedure | Major surgery | Wound, non-healed | Autologous bone marrow transplant | Autologous Stem Cell Rescue
Item
excluded therapies and medications, previous and concomitant : prior systemic anticancer chemotherapy or immunotherapy or targeted therapy,hormonal therapy within 2 weeks,local treatment modality within 4 weeks,radiotherapy within 3 weeks,major surgery and unhealed wound within 4 weeks,autologous bone marrow transplant or stem cell rescue within 4 months
boolean
C1883256 (UMLS CUI [1,1])
C0006826 (UMLS CUI [1,2])
C0021083 (UMLS CUI [2])
C2985566 (UMLS CUI [3])
C0279025 (UMLS CUI [4])
C1517925 (UMLS CUI [5])
C1522449 (UMLS CUI [6])
C0679637 (UMLS CUI [7])
C0750433 (UMLS CUI [8])
C0194037 (UMLS CUI [9])
C2825926 (UMLS CUI [10])
Condition Interferes with Study Subject Participation Status | Condition Interferes with Evaluation Research results
Item
other condition that may interfere with the patient's participation in the study or evaluation of the results
boolean
C0348080 (UMLS CUI [1,1])
C0521102 (UMLS CUI [1,2])
C2348568 (UMLS CUI [1,3])
C0348080 (UMLS CUI [2,1])
C0521102 (UMLS CUI [2,2])
C1261322 (UMLS CUI [2,3])
C0683954 (UMLS CUI [2,4])