Age
Item
age > 18 years
boolean
C0001779 (UMLS CUI [1])
Hepatitis C virus RNA assay
Item
serum hepatitis c rna > 10,000iu/ml
boolean
C1272251 (UMLS CUI [1])
Hepatitis C virus genotype determination
Item
hepatitis c virus genotype 1
boolean
C1533728 (UMLS CUI [1])
IL-28B polymorphism
Item
il28b polymorphism
boolean
C1425475 (UMLS CUI [1,1])
C0032529 (UMLS CUI [1,2])
Prior Therapy Chronic Hepatitis C
Item
previous treatment for chronic hepatitis c
boolean
C1514463 (UMLS CUI [1,1])
C0524910 (UMLS CUI [1,2])
Hepatitis | Alanine aminotransferase measurement | Aspartate aminotransferase measurement
Item
clinical or biological evidence of acute hepatitis, including serum alt or ast > 300u/ml
boolean
C0019158 (UMLS CUI [1])
C0201836 (UMLS CUI [2])
C0201899 (UMLS CUI [3])
HIV antibody positive | Hepatitis B surface antigen positive | Chronic liver disease
Item
hiv antibody positive, hepatitis b surface antigen positive or known diagnosis of other chronic liver disease
boolean
C0920548 (UMLS CUI [1])
C0149709 (UMLS CUI [2])
C0341439 (UMLS CUI [3])
Medical contraindication PEGINTERFERON/RIBAVIRIN Therapy
Item
contraindications to pr-based treatment:
boolean
C1301624 (UMLS CUI [1,1])
C1875630 (UMLS CUI [1,2])
C0087111 (UMLS CUI [1,3])
Mental disorder Uncontrolled
Item
1. uncontrolled psychiatric illness
boolean
C0004936 (UMLS CUI [1,1])
C0205318 (UMLS CUI [1,2])
Substance Dependence
Item
2. active substance dependency
boolean
C0038580 (UMLS CUI [1])
Autoimmune Disease
Item
3. known autoimmune disorder
boolean
C0004364 (UMLS CUI [1])
Thyroid Disease Untreated
Item
4. untreated thyroid disease
boolean
C0040128 (UMLS CUI [1,1])
C0332155 (UMLS CUI [1,2])
Seizure Uncontrolled
Item
5. uncontrolled seizure disorder
boolean
C0036572 (UMLS CUI [1,1])
C0205318 (UMLS CUI [1,2])
Pregnancy | Breast Feeding | Contraceptive methods Maintain Unable
Item
6. pregnancy, lactation or inability to maintain contraception
boolean
C0032961 (UMLS CUI [1])
C0006147 (UMLS CUI [2])
C0700589 (UMLS CUI [3,1])
C0024501 (UMLS CUI [3,2])
C1299582 (UMLS CUI [3,3])
Chronic Kidney Disease | Estimated Glomerular Filtration Rate
Item
7. chronic kidney disease w/ estimated gfr< 60
boolean
C1561643 (UMLS CUI [1])
C3811844 (UMLS CUI [2])
Absolute neutrophil count | Hemoglobin measurement | Platelet Count measurement
Item
8. anc<1.5/nl, hb<12g/dl, or platelets<75/nl
boolean
C0948762 (UMLS CUI [1])
C0518015 (UMLS CUI [2])
C0032181 (UMLS CUI [3])
Decompensated liver disease
Item
clinical or biochemical evidence of decompensated liver disease including:
boolean
C4075847 (UMLS CUI [1])
Encephalopathy | Ascites | Bleeding varices
Item
1. history of encephalopathy, ascites, or variceal bleeding or
boolean
C0085584 (UMLS CUI [1])
C0003962 (UMLS CUI [2])
C0333106 (UMLS CUI [3])
Serum total bilirubin measurement
Item
2. bilirubin > 3g/dl or inr > 1.5
boolean
C1278039 (UMLS CUI [1])
Life threatening illness | Median Survival Time Expected
Item
life threatening disorder with expected median survival less than 5 years
boolean
C3846017 (UMLS CUI [1])
C2986586 (UMLS CUI [2,1])
C1517001 (UMLS CUI [2,2])
Compliance behavior Unable Pharmacotherapy | Compliance behavior Unable Testing
Item
inability to comply with drug regimens or testing schedule required for study
boolean
C1321605 (UMLS CUI [1,1])
C1299582 (UMLS CUI [1,2])
C0013216 (UMLS CUI [1,3])
C1321605 (UMLS CUI [2,1])
C1299582 (UMLS CUI [2,2])
C0039593 (UMLS CUI [2,3])
Lacking Insurance Coverage Investigational New Drugs
Item
lack of insurance coverage for any of the study medications
boolean
C0332268 (UMLS CUI [1,1])
C0376629 (UMLS CUI [1,2])
C0013230 (UMLS CUI [1,3])