Adenocarcinoma of large intestine | Prior Therapy Absent Metastatic Lesion
Item
1. histologically confirmed adenocarcinoma of the colorectum with metastatic lesions and received no previous therapy for metastatic lesions;
boolean
C1319315 (UMLS CUI [1])
C1514463 (UMLS CUI [2,1])
C0332197 (UMLS CUI [2,2])
C1513183 (UMLS CUI [2,3])
Excision | Tumor tissue sample Quantity Size
Item
2. be able to undergo surgical resection to obtain at least 1cm3 tumor tissues;
boolean
C0728940 (UMLS CUI [1])
C0475358 (UMLS CUI [2,1])
C1265611 (UMLS CUI [2,2])
C0456389 (UMLS CUI [2,3])
Age
Item
3. the patients are from 18-75 years old regardless of gender;
boolean
C0001779 (UMLS CUI [1])
Life Expectancy | ECOG performance status
Item
4. an estimated life expectancy of more than 6 months with ecog≤2;
boolean
C0023671 (UMLS CUI [1])
C1520224 (UMLS CUI [2])
Liver function | Renal function | Bone Marrow function | Neutrophil count | Hemoglobin measurement | Platelet Count measurement | Creatinine measurement, serum | Serum total bilirubin measurement | Alanine aminotransferase measurement | Aspartate aminotransferase measurement | Secondary malignant neoplasm of liver
Item
5. adequate hepatic, renal, and bone marrow functions: neutrophilic granulocyte≥1.5×109/l, hb(hemoglobin)≥90g/l, plt(platelets)≥100×109/l, serum cr(creatinine)≤1.5-time upper normal limit, serum tbil(total bilirubin)≤1.5-time upper normal limit, both serum alt and ast(alanine aminotransferase and aspartate aminotransferase)≤2.5-time upper normal limit, hepatic metastases crc patients' serum alt/ast≤5-time upper normal limit;
boolean
C0232741 (UMLS CUI [1])
C0232804 (UMLS CUI [2])
C0005953 (UMLS CUI [3,1])
C0031843 (UMLS CUI [3,2])
C0200633 (UMLS CUI [4])
C0518015 (UMLS CUI [5])
C0032181 (UMLS CUI [6])
C0201976 (UMLS CUI [7])
C1278039 (UMLS CUI [8])
C0201836 (UMLS CUI [9])
C0201899 (UMLS CUI [10])
C0494165 (UMLS CUI [11])
Measurable Disease Quantity | Status post Excision
Item
6. at least one measurable lesion after surgical resection (according to the standard of recist1.1 version: response evaluation criteria in solid tumors 1.1 version);
boolean
C1513041 (UMLS CUI [1,1])
C1265611 (UMLS CUI [1,2])
C0231290 (UMLS CUI [2,1])
C0728940 (UMLS CUI [2,2])
Informed Consent
Item
7. written informed consent.
boolean
C0021430 (UMLS CUI [1])
Heart Disease Severe | Symptoms Coronary heart disease | Congestive heart failure New York Heart Association Classification | Cardiac Arrhythmia Severe | Requirement Pharmacotherapy | Myocardial Infarction | Dysfunction Pulmonary Severe | Peripheral Neuropathy | Hypertensive disease Unstable
Item
1. severe (ie, active) heart disease, such as coronary heart disease symptoms, the new york heart association (nyha) ii-class or more serious congestive heart failure or severe arrhythmia requiring medication intervention, or history of myocardial infarction within the last 12 months; severe pulmonary dysfunction; peripheral neuropathy; unstable hypertension;
boolean
C0018799 (UMLS CUI [1,1])
C0205082 (UMLS CUI [1,2])
C1457887 (UMLS CUI [2,1])
C0010068 (UMLS CUI [2,2])
C0018802 (UMLS CUI [3,1])
C1275491 (UMLS CUI [3,2])
C0003811 (UMLS CUI [4,1])
C0205082 (UMLS CUI [4,2])
C1514873 (UMLS CUI [5,1])
C0013216 (UMLS CUI [5,2])
C0027051 (UMLS CUI [6])
C3887504 (UMLS CUI [7,1])
C2709248 (UMLS CUI [7,2])
C0205082 (UMLS CUI [7,3])
C0031117 (UMLS CUI [8])
C0020538 (UMLS CUI [9,1])
C0443343 (UMLS CUI [9,2])
Metastatic Lesion Liver Volume Percentage
Item
2. metastases lesions> 50% of liver volume;
boolean
C1513183 (UMLS CUI [1,1])
C0023884 (UMLS CUI [1,2])
C0449468 (UMLS CUI [1,3])
C0439165 (UMLS CUI [1,4])
Autoimmune Diseases | Organ Transplantation Requirement Therapeutic immunosuppression | Requirement Systemic Corticosteroid Therapy Long-term
Item
3. autoimmune diseases, organ transplantation requiring immunosuppressive therapy and patients requiring long-term systemic corticosteroid therapy;
boolean
C0004364 (UMLS CUI [1])
C0029216 (UMLS CUI [2,1])
C1514873 (UMLS CUI [2,2])
C0021079 (UMLS CUI [2,3])
C1514873 (UMLS CUI [3,1])
C4053960 (UMLS CUI [3,2])
C0443252 (UMLS CUI [3,3])
Malignant Neoplasms | Exception Basal cell carcinoma Cured | Exception Carcinoma in situ of uterine cervix Cured
Item
4. history of other malignant diseases (except cured basal cell carcinoma and cervical carcinoma in situ) in the last 5 years;
boolean
C0006826 (UMLS CUI [1])
C1705847 (UMLS CUI [2,1])
C0007117 (UMLS CUI [2,2])
C1880198 (UMLS CUI [2,3])
C1705847 (UMLS CUI [3,1])
C0851140 (UMLS CUI [3,2])
C1880198 (UMLS CUI [3,3])
Pregnancy | Breast Feeding | Childbearing Potential Pregnancy test positive | Childbearing Potential Pregnancy Test Absent | Menopausal Status
Item
5. pregnant or lactating women (women at childbearing age in the baseline pregnancy test positive or pregnancy test not examined. menopausal women have menopause at least 12 months);
boolean
C0032961 (UMLS CUI [1])
C0006147 (UMLS CUI [2])
C3831118 (UMLS CUI [3,1])
C0240802 (UMLS CUI [3,2])
C3831118 (UMLS CUI [4,1])
C0032976 (UMLS CUI [4,2])
C0332197 (UMLS CUI [4,3])
C3829127 (UMLS CUI [5])
Communicable Disease | Chronic infectious disease | Communicable Disease Severe Uncontrolled | Comorbidity Serious Uncontrolled
Item
6. acute or chronic infectious diseases in active phase; severe uncontrolled infection, or other serious uncontrolled concomitant diseases;
boolean
C0009450 (UMLS CUI [1])
C0151317 (UMLS CUI [2])
C0009450 (UMLS CUI [3,1])
C0205082 (UMLS CUI [3,2])
C0205318 (UMLS CUI [3,3])
C0009488 (UMLS CUI [4,1])
C0205404 (UMLS CUI [4,2])
C0205318 (UMLS CUI [4,3])
History of allergies | Patient constitution allergic
Item
7. definite history of allergy or allergic constitutions;
boolean
C0489531 (UMLS CUI [1])
C0683521 (UMLS CUI [2,1])
C0700624 (UMLS CUI [2,2])
Chemotherapy | Therapeutic radiology procedure | Immunotherapy
Item
8. chemotherapy, radiotherapy or immunotherapy within four weeks;
boolean
C0392920 (UMLS CUI [1])
C1522449 (UMLS CUI [2])
C0021083 (UMLS CUI [3])
Investigational New Drugs | Procedures Investigational
Item
9. administration of other investigational drugs or procedures within four weeks.
boolean
C0013230 (UMLS CUI [1])
C0184661 (UMLS CUI [2,1])
C1517586 (UMLS CUI [2,2])