Solid tumour Advanced Locally Unresponsive to Treatment | Solid tumour metastatic Unresponsive to Treatment
Item
part 1: histologically or cytologically confirmed, locally advanced or metastatic, treatment-refractory solid tumors
boolean
C0280100 (UMLS CUI [1,1])
C0205179 (UMLS CUI [1,2])
C1517927 (UMLS CUI [1,3])
C0205269 (UMLS CUI [1,4])
C0280100 (UMLS CUI [2,1])
C1522484 (UMLS CUI [2,2])
C0205269 (UMLS CUI [2,3])
Non-Small Cell Lung Carcinoma Advanced Locally | Non-small cell lung cancer metastatic | Therapeutic procedure Quantity Squamous cell carcinoma | Therapeutic procedure Quantity Nonsquamous nonsmall cell neoplasm of lung | Therapeutic procedure Quantity Colorectal Carcinoma | Therapeutic procedure Quantity Pancreatic carcinoma | Therapeutic procedure Quantity Ovarian Carcinoma | Therapeutic procedure Quantity Sarcoma
Item
part 2: histologically or cytologically confirmed, locally advanced or metastatic: nsclc (squamous or non-squamous cell carcinoma; up to 2 prior treatment regimens), colorectal cancer (up to 2 prior treatment regimens), pancreatic cancer (up to 1 prior treatment regimen), ovarian cancer (up to 2 prior treatment regimens), or sarcoma (up to 2 prior treatment regimens), according to cohort availability
boolean
C0007131 (UMLS CUI [1,1])
C0205179 (UMLS CUI [1,2])
C1517927 (UMLS CUI [1,3])
C0278987 (UMLS CUI [2])
C0087111 (UMLS CUI [3,1])
C1265611 (UMLS CUI [3,2])
C0007137 (UMLS CUI [3,3])
C0087111 (UMLS CUI [4,1])
C1265611 (UMLS CUI [4,2])
C2585890 (UMLS CUI [4,3])
C0087111 (UMLS CUI [5,1])
C1265611 (UMLS CUI [5,2])
C0009402 (UMLS CUI [5,3])
C0087111 (UMLS CUI [6,1])
C1265611 (UMLS CUI [6,2])
C0235974 (UMLS CUI [6,3])
C0087111 (UMLS CUI [7,1])
C1265611 (UMLS CUI [7,2])
C0029925 (UMLS CUI [7,3])
C0087111 (UMLS CUI [8,1])
C1265611 (UMLS CUI [8,2])
C1261473 (UMLS CUI [8,3])
ECOG performance status
Item
eastern cooperative group (ecog performance status of 0 or 1
boolean
C1520224 (UMLS CUI [1])
Age
Item
women or men ≥16 years of age
boolean
C0001779 (UMLS CUI [1])
Hematologic function | Renal function | Liver function | Blood coagulation | Glycemia function
Item
adequate hematology, renal, hepatic, coagulation and glycemic function.
boolean
C0221130 (UMLS CUI [1])
C0232804 (UMLS CUI [2])
C0232741 (UMLS CUI [3])
C0005778 (UMLS CUI [4])
C0005802 (UMLS CUI [5,1])
C0031843 (UMLS CUI [5,2])
CNS disorder Uncontrolled
Item
presence of uncontrolled central nervous system (cns) disease
boolean
C0007682 (UMLS CUI [1,1])
C0205318 (UMLS CUI [1,2])
Systemic Chemotherapy | Hormone Therapy | Immunotherapy | Monoclonal antibodies, antineoplastic
Item
systemic chemotherapy, hormonal therapy, immunotherapy, experimental or approved anticancer proteins/antibodies therapy ≤28 days before enrollment.
boolean
C1883256 (UMLS CUI [1])
C0279025 (UMLS CUI [2])
C0021083 (UMLS CUI [3])
C3542957 (UMLS CUI [4])
Death Receptor agonists | AMG 951 | apomab | mapatumumab | lexatumumab | CS-1008
Item
prior treatment with death receptor agonists (including but not limited to rhapo2l/trail [amg951], apomab, mapatumumab, lexatumumab, cs-1008)
boolean
C1720947 (UMLS CUI [1,1])
C0243192 (UMLS CUI [1,2])
C2830007 (UMLS CUI [2,1])
C2346838 (UMLS CUI [2,2])
C1665688 (UMLS CUI [3])
C1721684 (UMLS CUI [4])
C1831890 (UMLS CUI [5])
IGF Receptor antagonists | CP 751 | Other Coding | MK 0646 | AVE1642 | IMC-A12
Item
prior treatment with igf receptor antagonists (including but not limited to cp-751, 871, mk0646, ave1642 or imc-a12)
boolean
C0140079 (UMLS CUI [1,1])
C0243076 (UMLS CUI [1,2])
C1707143 (UMLS CUI [2])
C3846158 (UMLS CUI [3])
C1831888 (UMLS CUI [4])
C2703165 (UMLS CUI [5])
C3180625 (UMLS CUI [6])