Colorectal Cancer Advanced Locally | Colorectal cancer metastatic
Item
histologically confirmed locally advanced or metastatic colorectal cancer
boolean
C0009402 (UMLS CUI [1,1])
C0205179 (UMLS CUI [1,2])
C1517927 (UMLS CUI [1,3])
C0948380 (UMLS CUI [2])
Measurable Disease | Evaluable Disease
Item
measurable or evaluable disease according to the response evaluation criteria in solid tumors (recist)
boolean
C1513041 (UMLS CUI [1])
C1516986 (UMLS CUI [2])
ECOG performance status
Item
ecog performance status ≤ 2
boolean
C1520224 (UMLS CUI [1])
Age
Item
age 18 - 72 years
boolean
C0001779 (UMLS CUI [1])
In complete remission Post First line treatment | Partial response Post First line treatment | Stable Disease Post First line treatment | irinotecan | bevacizumab
Item
patients who have had a cr, pr or sd after 1st line therapy based on irinotecan+bevacizumab
boolean
C0677874 (UMLS CUI [1,1])
C0687676 (UMLS CUI [1,2])
C1708063 (UMLS CUI [1,3])
C1521726 (UMLS CUI [2,1])
C0687676 (UMLS CUI [2,2])
C1708063 (UMLS CUI [2,3])
C0677946 (UMLS CUI [3,1])
C0687676 (UMLS CUI [3,2])
C1708063 (UMLS CUI [3,3])
C0123931 (UMLS CUI [4])
C0796392 (UMLS CUI [5])
Paraffin Block Primary tumor | KRAS gene targeted mutation analysis
Item
paraffin block from the primary tumor in order to perform tha mutational analysis of the kras gene
boolean
C1519524 (UMLS CUI [1,1])
C0677930 (UMLS CUI [1,2])
C4264276 (UMLS CUI [2])
Liver function | Serum total bilirubin measurement | Aspartate aminotransferase measurement | Alanine aminotransferase measurement | Alkaline phosphatase measurement | Renal function | Creatinine measurement, serum | Bone Marrow function | Absolute neutrophil count | Platelet Count measurement
Item
adequate liver (bilirubin ≤ 1.5 upper normal limit, sgot/sgpt ≤ 4 upper normal limit, alp ≤ 2.5 upper normal limit),renal (creatinine ≤ 1.5 upper normal limit) and bone marrow (anc ≥ 1,500/mm3, plt ≥100,000/mm3) function
boolean
C0232741 (UMLS CUI [1])
C1278039 (UMLS CUI [2])
C0201899 (UMLS CUI [3])
C0201836 (UMLS CUI [4])
C0201850 (UMLS CUI [5])
C0232804 (UMLS CUI [6])
C0201976 (UMLS CUI [7])
C0005953 (UMLS CUI [8,1])
C0031843 (UMLS CUI [8,2])
C0948762 (UMLS CUI [9])
C0032181 (UMLS CUI [10])
Comprehension Study Protocol
Item
patients must be able to understand the nature of this study
boolean
C0162340 (UMLS CUI [1,1])
C2348563 (UMLS CUI [1,2])
Informed Consent
Item
written informed consent
boolean
C0021430 (UMLS CUI [1])
CNS metastases | Metastatic malignant neoplasm to brain
Item
presence of central nervous system or brain metastases
boolean
C0686377 (UMLS CUI [1])
C0220650 (UMLS CUI [2])
Pregnancy | Breast Feeding
Item
pregnant or lactating woman
boolean
C0032961 (UMLS CUI [1])
C0006147 (UMLS CUI [2])
Life Expectancy
Item
life expectancy < 3 months
boolean
C0023671 (UMLS CUI [1])
Prior radiation therapy | Therapeutic radiology procedure Bone Marrow Percentage | Radiotherapy, Targeted
Item
previous radiotherapy within the last 4 weeks or > 25% of bone marrow or in the field where the treatment target is located
boolean
C0279134 (UMLS CUI [1])
C1522449 (UMLS CUI [2,1])
C0005953 (UMLS CUI [2,2])
C0439165 (UMLS CUI [2,3])
C0205918 (UMLS CUI [3])
Peripheral Neuropathy CTCAE Grades
Item
peripheral neuropathy grade ≥2
boolean
C0031117 (UMLS CUI [1,1])
C1516728 (UMLS CUI [1,2])
Hypersensitivity Erbitux
Item
known hypersensitivity to erbitux
boolean
C0020517 (UMLS CUI [1,1])
C1173436 (UMLS CUI [1,2])
Infiltration metastatic Liver Percentage
Item
metastatic infiltration of the liver >50%
boolean
C0332448 (UMLS CUI [1,1])
C1522484 (UMLS CUI [1,2])
C0023884 (UMLS CUI [1,3])
C0439165 (UMLS CUI [1,4])
Chronic diarrhea | Partial bowel obstruction | Total colectomy
Item
patients with chronic diarrhea (at least for 3 months) or partial bowel obstruction or total colectomy
boolean
C0401151 (UMLS CUI [1])
C1328480 (UMLS CUI [2])
C0192871 (UMLS CUI [3])
Communicable Disease
Item
active infection
boolean
C0009450 (UMLS CUI [1])
Second Primary Cancers | Exception Skin carcinoma | Exception Carcinoma in situ of uterine cervix
Item
second primary malignancy, except for non-melanoma skin cancer and in situ cervical cancer
boolean
C0751623 (UMLS CUI [1])
C1705847 (UMLS CUI [2,1])
C0699893 (UMLS CUI [2,2])
C1705847 (UMLS CUI [3,1])
C0851140 (UMLS CUI [3,2])
Mental disorders Exclude Protocol Compliance | Social situation Excludes Protocol Compliance
Item
psychiatric illness or social situation that would preclude study compliance
boolean
C0004936 (UMLS CUI [1,1])
C0332196 (UMLS CUI [1,2])
C0525058 (UMLS CUI [1,3])
C0748872 (UMLS CUI [2,1])
C0332196 (UMLS CUI [2,2])
C0525058 (UMLS CUI [2,3])