Age | Racial group | Gender
Item
older than 18 years of age, of any race, and gender;
boolean
C0001779 (UMLS CUI [1])
C0034510 (UMLS CUI [2])
C0079399 (UMLS CUI [3])
Colorectal cancer recurrent | First line treatment | Disease Progression
Item
diagnosis of histologically confirmed relapsed or recurrent colorectal carcinoma that has progressed on at least first-line therapy;
boolean
C0854750 (UMLS CUI [1])
C1708063 (UMLS CUI [2])
C0242656 (UMLS CUI [3])
Tumor Growth rate CT scan | Tumor Growth rate MRI scan
Item
must have a ct or mri scan performed at some point during their immediate prior treatment or observation in order to determine tumor growth rate;
boolean
C0027651 (UMLS CUI [1,1])
C0449249 (UMLS CUI [1,2])
C0040405 (UMLS CUI [1,3])
C0027651 (UMLS CUI [2,1])
C0449249 (UMLS CUI [2,2])
C0024485 (UMLS CUI [2,3])
Measurable Disease CT | Measurable Disease MRI
Item
must have measurable disease on a ct or mri study, performed during screening;
boolean
C1513041 (UMLS CUI [1,1])
C0040405 (UMLS CUI [1,2])
C1513041 (UMLS CUI [2,1])
C0024485 (UMLS CUI [2,2])
ECOG performance status | Life Expectancy
Item
must have an eastern cooperative oncology group (ecog) performance status of <=2 and a minimum life expectancy of ≥4 months;
boolean
C1520224 (UMLS CUI [1])
C0023671 (UMLS CUI [2])
Organ function
Item
must have adequate organ function within 3 weeks prior to treatment assignment
boolean
C0678852 (UMLS CUI [1])
Cancer Other
Item
history of another malignancy;
boolean
C1707251 (UMLS CUI [1])
Metastatic Malignant Neoplasm to the Leptomeninges Treated | Metastatic Malignant Neoplasm to the Leptomeninges untreated | CNS lesion metastatic
Item
known treated or untreated leptomeningeal metastasis, or a metastatic central nervous system lesion;
boolean
C1704231 (UMLS CUI [1,1])
C1522326 (UMLS CUI [1,2])
C1704231 (UMLS CUI [2,1])
C0332155 (UMLS CUI [2,2])
C0742468 (UMLS CUI [3,1])
C1522484 (UMLS CUI [3,2])
Operative Surgical Procedures
Item
surgery within 3 weeks;
boolean
C0543467 (UMLS CUI [1])
Therapeutic radiology procedure
Item
radiation therapy within 6 weeks;
boolean
C1522449 (UMLS CUI [1])
Diabetic - poor control | Glucohemoglobin measurement
Item
a history of uncontrolled diabetes mellitus, defined as a hemoglobin a1c of >7.5% in a patient with known diabetes mellitus;
boolean
C0421258 (UMLS CUI [1])
C0202054 (UMLS CUI [2])
Myocardial Infarction | Angina, Unstable | Angina Pectoris Uncontrolled | Congestive heart failure New York Heart Association Classification | Uncontrolled hypertension | Cardiac Arrhythmia | ECG abnormality
Item
a recent myocardial infarction (within the past year); or a subject who at the time of screening presents with unstable or uncontrolled angina, new york heart association class iii or iv congestive heart failure, uncontrolled hypertension, clinically significant cardiac dysrhythmia or clinically significant electrocardiogram abnormality;
boolean
C0027051 (UMLS CUI [1])
C0002965 (UMLS CUI [2])
C0002962 (UMLS CUI [3,1])
C0205318 (UMLS CUI [3,2])
C0018802 (UMLS CUI [4,1])
C1275491 (UMLS CUI [4,2])
C1868885 (UMLS CUI [5])
C0003811 (UMLS CUI [6])
C0522055 (UMLS CUI [7])
Communicable Disease
Item
an active infection;
boolean
C0009450 (UMLS CUI [1])
Hepatitis | Hepatitis C antibody positive | Hepatitis B surface antigen positive | HIV Seropositivity
Item
a subject with clinically significant hepatitis at screening, or a subject that is hepatitis c antibody positive, hepatitis b surface antigen positive, or human immunodeficiency virus seropositive.
boolean
C0019158 (UMLS CUI [1])
C0281863 (UMLS CUI [2])
C0149709 (UMLS CUI [3])
C0019699 (UMLS CUI [4])