Squamous cell carcinoma of lung TNM clinical staging | Adenocarcinoma of lung TNM clinical staging | Pleural Effusion, Malignant | Malignant pericardial effusion
Item
patients with histologically proven stage iv and stage iii (with malignant pleural or pericardial effusion) squamous or adenocarcinoma carcinomas of the lung
boolean
C0149782 (UMLS CUI [1,1])
C3258246 (UMLS CUI [1,2])
C0152013 (UMLS CUI [2,1])
C3258246 (UMLS CUI [2,2])
C0080032 (UMLS CUI [3])
C0220655 (UMLS CUI [4])
Tumor tissue sample Formalin-fixed paraffin-embedded Molecular Analysis
Item
adequate formalin fixed paraffin embedded tumor sample provided for molecular analysis
boolean
C0475358 (UMLS CUI [1,1])
C2711483 (UMLS CUI [1,2])
C1513380 (UMLS CUI [1,3])
Cancer treatment Absent Neoplasm Metastasis | Cancer treatment Absent Advanced disease | Adjuvant Chemotherapy Disease Free of
Item
no previous anticancer treatment for metastatic/advanced disease. patients who received prior adjuvant chemotherapy are eligible if they have remained free of disease for at least 6 months after the completion of adjuvant therapy.
boolean
C0920425 (UMLS CUI [1,1])
C0332197 (UMLS CUI [1,2])
C0027627 (UMLS CUI [1,3])
C0920425 (UMLS CUI [2,1])
C0332197 (UMLS CUI [2,2])
C0679246 (UMLS CUI [2,3])
C0085533 (UMLS CUI [3,1])
C0012634 (UMLS CUI [3,2])
C0332296 (UMLS CUI [3,3])
Age
Item
age above 18 years
boolean
C0001779 (UMLS CUI [1])
ECOG performance status
Item
performance status (ecog) 0-2
boolean
C1520224 (UMLS CUI [1])
Life Expectancy
Item
life expectancy >= 3 months
boolean
C0023671 (UMLS CUI [1])
Risk Conception Contraceptive methods
Item
effective contraception for both male and female subjects if the risk of conception exists
boolean
C0035647 (UMLS CUI [1,1])
C0009637 (UMLS CUI [1,2])
C0700589 (UMLS CUI [1,3])
Parameters Hematologic | Absolute neutrophil count | Platelet Count measurement | Creatinine measurement, serum | Glomerular Filtration Rate | Serum total bilirubin measurement | Aspartate aminotransferase measurement | Alanine aminotransferase measurement
Item
adequate hematologic parameters (absolute neutrophil count >= 1.5x109/l and platelets >= 100x109/l), creatinine (gfr>= 60ml/min) and total bilirubin < 1.5 times the upper limit of normal; aspartate and alanine aminotransferase < 2,5 times the upper limit of normal
boolean
C0449381 (UMLS CUI [1,1])
C0205488 (UMLS CUI [1,2])
C0948762 (UMLS CUI [2])
C0032181 (UMLS CUI [3])
C0201976 (UMLS CUI [4])
C0017654 (UMLS CUI [5])
C1278039 (UMLS CUI [6])
C0201899 (UMLS CUI [7])
C0201836 (UMLS CUI [8])
Informed Consent
Item
all patients will have to sign written informed consent in order to participate in the study
boolean
C0021430 (UMLS CUI [1])
Non-Squamous Non-Small Cell Lung Carcinoma | Medical contraindication Absent bevacizumab
Item
patients with non-squamous tumors who have no contradiction for administration of bevacizumab
boolean
C4324656 (UMLS CUI [1])
C1301624 (UMLS CUI [2,1])
C0332197 (UMLS CUI [2,2])
C0796392 (UMLS CUI [2,3])
Communicable Disease | Malnutrition | Weight decreased Percentage
Item
active infection or malnutrition (loss of more than 20% of the body weight)
boolean
C0009450 (UMLS CUI [1])
C0162429 (UMLS CUI [2])
C1262477 (UMLS CUI [3,1])
C0439165 (UMLS CUI [3,2])
Allergic Reaction Component Therapeutic procedure
Item
known hypersensitivity reaction to any of the component of the treatment
boolean
C1527304 (UMLS CUI [1,1])
C1705248 (UMLS CUI [1,2])
C0087111 (UMLS CUI [1,3])
Immunotherapy Systemic chronic
Item
concurrent or previous chronic systemic immune therapy
boolean
C0021083 (UMLS CUI [1,1])
C0205373 (UMLS CUI [1,2])
C0205191 (UMLS CUI [1,3])
Pregnancy | Breast Feeding | Pregnancy Absent Serum Beta-HCG Test
Item
pregnancy (absence to be confirmed by ß-hcg test) or lactation period
boolean
C0032961 (UMLS CUI [1])
C0006147 (UMLS CUI [2])
C0032961 (UMLS CUI [3,1])
C0332197 (UMLS CUI [3,2])
C1255526 (UMLS CUI [3,3])
Substance Use Disorders
Item
known alcohol/drug abuse
boolean
C0038586 (UMLS CUI [1])
Legal capacity Lacking | Legal capacity Limited
Item
legal incapacity or limited legal capacity
boolean
C0683673 (UMLS CUI [1,1])
C0332268 (UMLS CUI [1,2])
C0683673 (UMLS CUI [2,1])
C0439801 (UMLS CUI [2,2])
Medical condition Preventing Patient Completion of clinical trial | Mental condition Preventing Patient Completion of clinical trial | Medical condition Preventing Informed Consent | Mental condition Preventing Informed Consent
Item
medical or psychological condition which in the opinion of the investigator would not permit the subject to complete the study or sign meaningful informed consent
boolean
C3843040 (UMLS CUI [1,1])
C1292733 (UMLS CUI [1,2])
C0030705 (UMLS CUI [1,3])
C2732579 (UMLS CUI [1,4])
C3840291 (UMLS CUI [2,1])
C1292733 (UMLS CUI [2,2])
C0030705 (UMLS CUI [2,3])
C2732579 (UMLS CUI [2,4])
C3843040 (UMLS CUI [3,1])
C1292733 (UMLS CUI [3,2])
C0021430 (UMLS CUI [3,3])
C3840291 (UMLS CUI [4,1])
C1292733 (UMLS CUI [4,2])
C0021430 (UMLS CUI [4,3])
Primary tumor second | Exception Skin carcinoma | Exception Carcinoma in situ of uterine cervix
Item
a second primary tumor other than non-melanoma skin cancer or in situ cervical carcinoma
boolean
C0677930 (UMLS CUI [1,1])
C0205436 (UMLS CUI [1,2])
C1705847 (UMLS CUI [2,1])
C0699893 (UMLS CUI [2,2])
C1705847 (UMLS CUI [3,1])
C0851140 (UMLS CUI [3,2])
Prior radiation therapy Target Lesion | Palliative course of radiotherapy | Neoplasm Metastasis Measurable outside Radiation Field
Item
previous radiotherapy to the target lesions. patients treated with palliative radiotherapy had to have measurable metastatic disease outside the irradiation fields
boolean
C0279134 (UMLS CUI [1,1])
C2986546 (UMLS CUI [1,2])
C0475092 (UMLS CUI [2])
C0027627 (UMLS CUI [3,1])
C1513040 (UMLS CUI [3,2])
C0205101 (UMLS CUI [3,3])
C1882536 (UMLS CUI [3,4])
Cardiac dysfunction Severe | Angina, Unstable | High risk of Cardiac Arrhythmia Uncontrolled
Item
patients with severe cardiac dysfunction, unstable angina petrosis, or high risk of uncontrolled arrhythmia
boolean
C3277906 (UMLS CUI [1,1])
C0205082 (UMLS CUI [1,2])
C0002965 (UMLS CUI [2])
C0332167 (UMLS CUI [3,1])
C0003811 (UMLS CUI [3,2])
C0205318 (UMLS CUI [3,3])