Non-Squamous Non-Small Cell Lung Carcinoma Advanced Locally | Metastatic Non-Squamous Non-Small Cell Lung Carcinoma
Item
histological diagnosis of nsclc with locally advanced or metastatic disease that is of non-squamous histology.
boolean
C4324656 (UMLS CUI [1,1])
C0205179 (UMLS CUI [1,2])
C1517927 (UMLS CUI [1,3])
C4288755 (UMLS CUI [2])
Former light tobacco smoker | Never smoked tobacco
Item
participants must be "light ex-smokers" or "never-smokers".
boolean
C3494627 (UMLS CUI [1])
C0425293 (UMLS CUI [2])
Former light tobacco smoker | Stopped smoking ___ years ago | Smoking cigarettes: ____ pack-years
Item
"light ex-smokers" defined as having ceased smoking for greater than or equal to 5 years and not to have exceeded 10 pack-years.
boolean
C3494627 (UMLS CUI [1])
C3693442 (UMLS CUI [2])
C2230126 (UMLS CUI [3])
Never smoked tobacco | Smoking Cigarette Number Lifetime
Item
"never-smokers" are defined as having smoked <100 cigarettes or equivalent during his/her lifetime.
boolean
C0425293 (UMLS CUI [1])
C0037369 (UMLS CUI [2,1])
C0677453 (UMLS CUI [2,2])
C0237753 (UMLS CUI [2,3])
C4071830 (UMLS CUI [2,4])
East Asian ethnicity
Item
participants must be of east asian ethnicity.
boolean
C4540996 (UMLS CUI [1])
Systemic therapy Absent Malignant neoplasm of lung
Item
no prior systemic therapy for lung cancer.
boolean
C1515119 (UMLS CUI [1,1])
C0332197 (UMLS CUI [1,2])
C0242379 (UMLS CUI [1,3])
ECOG performance status
Item
eastern cooperative oncology group (ecog) performance status of 0 or 1.
boolean
C1520224 (UMLS CUI [1])
Body Fluid Space Third Clinical Significance | Physical Examination | Ascites | Pleural effusion | Drainage Unsuccessful
Item
presence of clinically significant (by physical exam) third-space fluid collections, for example, ascites or pleural effusions that cannot be controlled by drainage or other procedures prior to study entry.
boolean
C0005889 (UMLS CUI [1,1])
C1883067 (UMLS CUI [1,2])
C0205437 (UMLS CUI [1,3])
C2826293 (UMLS CUI [1,4])
C0031809 (UMLS CUI [2])
C0003962 (UMLS CUI [3])
C0032227 (UMLS CUI [4])
C0013103 (UMLS CUI [5,1])
C1272705 (UMLS CUI [5,2])
Lung Diseases, Interstitial | Participants Asymptomatic | Radiography Change Stable chronic
Item
any evidence of clinically active interstitial lung disease. asymptomatic participants with chronic, stable, radiographic changes are eligible.
boolean
C0206062 (UMLS CUI [1])
C0679646 (UMLS CUI [2,1])
C0231221 (UMLS CUI [2,2])
C0034571 (UMLS CUI [3,1])
C0392747 (UMLS CUI [3,2])
C0205360 (UMLS CUI [3,3])
C0205191 (UMLS CUI [3,4])
EGFR gene mutation
Item
participants whose epidermal growth factor receptor (egfr) mutation status is known prior to study entry will be excluded. participants in which egfr mutation testing has not been performed, or whose egfr mutation status is unknown or inconclusive at study entry are eligible.
boolean
C3266992 (UMLS CUI [1])