Adult | Gender | Secondary malignant neoplasm of female breast Inappropriate Curative Surgery | Locally advanced breast cancer Inappropriate Curative Surgery | Secondary malignant neoplasm of female breast Inappropriate Therapeutic radiology procedure Curative | Locally advanced breast cancer Inappropriate Therapeutic radiology procedure Curative
Item
adult women with metastatic or locally advanced breast cancer not amenable to curative treatment by surgery or radiotherapy.
boolean
C0001675 (UMLS CUI [1])
C0079399 (UMLS CUI [2])
C0346993 (UMLS CUI [3,1])
C1548788 (UMLS CUI [3,2])
C1511562 (UMLS CUI [3,3])
C3495949 (UMLS CUI [4,1])
C1548788 (UMLS CUI [4,2])
C1511562 (UMLS CUI [4,3])
C0346993 (UMLS CUI [5,1])
C1548788 (UMLS CUI [5,2])
C1522449 (UMLS CUI [5,3])
C1276305 (UMLS CUI [5,4])
C3495949 (UMLS CUI [6,1])
C1548788 (UMLS CUI [6,2])
C1522449 (UMLS CUI [6,3])
C1276305 (UMLS CUI [6,4])
Oestrogen receptor positive breast cancer
Item
histological or cytological confirmation of estrogen-receptor positive (er+) breast cancer
boolean
C2938924 (UMLS CUI [1])
Postmenopausal state
Item
postmenopausal women
boolean
C0232970 (UMLS CUI [1])
Recurrence | Disease Progression | Systemic therapy
Item
radiological or clinical evidence of recurrence or progression on last systemic therapy prior to enrollment
boolean
C0034897 (UMLS CUI [1])
C0242656 (UMLS CUI [2])
C1515119 (UMLS CUI [3])
Resistant to Non-Steroidal Aromatase Inhibitor
Item
resistance to treatment with a non-steroidal aromatase inhibitor
boolean
C0332325 (UMLS CUI [1,1])
C1518386 (UMLS CUI [1,2])
Platelet Count measurement
Item
serum platelets ≥ 100x10e9/l
boolean
C0032181 (UMLS CUI [1])
Everolimus Dose Adjustment Recommended | Hepatic impairment Child-Pugh Classification
Item
everolimus dose adjustment is recommended for patients with hepatic impairment (child-pugh a/b/c)
boolean
C0541315 (UMLS CUI [1,1])
C2826232 (UMLS CUI [1,2])
C0034866 (UMLS CUI [1,3])
C0948807 (UMLS CUI [2,1])
C4050412 (UMLS CUI [2,2])
ECOG performance status | Karnofsky Performance Status
Item
performance status ecog 0 - 2 (karnofsky index: 60 - 100)
boolean
C1520224 (UMLS CUI [1])
C0206065 (UMLS CUI [2])
Neoplasm HER2 Overexpression
Item
patients with a her2-overexpressing tumor
boolean
C0027651 (UMLS CUI [1,1])
C0069515 (UMLS CUI [1,2])
C1514559 (UMLS CUI [1,3])
Hypersensitivity mTOR Inhibitors | Hypersensitivity Sirolimus
Item
known hypersensitivity to mtor inhibitors, e.g. sirolimus (rapamycin).
boolean
C0020517 (UMLS CUI [1,1])
C1515672 (UMLS CUI [1,2])
C0020517 (UMLS CUI [2,1])
C0072980 (UMLS CUI [2,2])
HIV Seropositivity | Hepatitis B | Hepatitis C
Item
patients with a known history of hiv seropositivity or hepatitis b or c
boolean
C0019699 (UMLS CUI [1])
C0019163 (UMLS CUI [2])
C0019196 (UMLS CUI [3])
Diabetic - poor control
Item
uncontrolled diabetes mellitus
boolean
C0421258 (UMLS CUI [1])
Impaired gastrointestinal system function | Gastrointestinal Disease Changing Absorption Investigational New Drugs | Ulcer | Nausea Uncontrolled | Vomiting | Diarrhea | Malabsorption Syndrome
Item
impairment of gastrointestinal function or gastrointestinal disease that may significantly alter the absorption of study drugs (e.g., ulcerative disease, uncontrolled nausea, vomiting, diarrhea, malabsorption syndrome)
boolean
C0232459 (UMLS CUI [1])
C0017178 (UMLS CUI [2,1])
C0392747 (UMLS CUI [2,2])
C0237442 (UMLS CUI [2,3])
C0013230 (UMLS CUI [2,4])
C0041582 (UMLS CUI [3])
C0027497 (UMLS CUI [4,1])
C0205318 (UMLS CUI [4,2])
C0042963 (UMLS CUI [5])
C0011991 (UMLS CUI [6])
C0024523 (UMLS CUI [7])
CYP3A Inhibitors | CYP3A Inducers
Item
patients being treated with drugs recognized as being strong inhibitors or inducers of the isoenzyme cyp3a
boolean
C3850056 (UMLS CUI [1])
C3850044 (UMLS CUI [2])