Timepoint Diagnosis
Item
at time of diagnosis
boolean
C2348792 (UMLS CUI [1,1])
C0011900 (UMLS CUI [1,2])
Multiple Myeloma de novo | Age | First Relapse | Screening Loss of Chromosome 13 | Beta-2-microglobulin measurement
Item
de novo multiple myeloma patients under 65 or in first relapse, in whom screening for chromosome 13 deletion and beta2microglobulin assay have been performed.
boolean
C0026764 (UMLS CUI [1,1])
C1515568 (UMLS CUI [1,2])
C0001779 (UMLS CUI [2])
C4054953 (UMLS CUI [3])
C0220908 (UMLS CUI [4,1])
C1517957 (UMLS CUI [4,2])
C0201910 (UMLS CUI [5])
Durie/Salmon Stage | Bone lesion Symptomatic Radiologic examination
Item
salmon and durie stage: iii, ii, i with symptomatic bone lesion (radiological)
boolean
C4528204 (UMLS CUI [1])
C0238792 (UMLS CUI [2,1])
C0231220 (UMLS CUI [2,2])
C0043299 (UMLS CUI [2,3])
Informed Consent
Item
patient's written informed consent
boolean
C0021430 (UMLS CUI [1])
Sign or Symptom Heart failure Absent | Sign or Symptom Coronary insufficiency Absent | Left ventricular ejection fraction
Item
no clinical signs of heart failure or coronary insufficiency with lvef>50%
boolean
C3540840 (UMLS CUI [1,1])
C0018801 (UMLS CUI [1,2])
C0332197 (UMLS CUI [1,3])
C3540840 (UMLS CUI [2,1])
C0542052 (UMLS CUI [2,2])
C0332197 (UMLS CUI [2,3])
C0428772 (UMLS CUI [3])
Hepatic Insufficiency Absent | Serum total bilirubin measurement | Aspartate aminotransferase measurement | Alanine aminotransferase measurement | Alkaline phosphatase measurement
Item
no hepatic in insufficiency: bilirubin<35μmol/l and sgot, sgpt, alkaline phosphatase less than 2.5 n
boolean
C1306571 (UMLS CUI [1,1])
C0332197 (UMLS CUI [1,2])
C1278039 (UMLS CUI [2])
C0201899 (UMLS CUI [3])
C0201836 (UMLS CUI [4])
C0201850 (UMLS CUI [5])
Respiratory Insufficiency Absent | Lung function testing normal | Carbon Monoxide Diffusing Capability Test
Item
no respiratory insufficiency: normal pulmonary function tests and dlco>50%
boolean
C0035229 (UMLS CUI [1,1])
C0332197 (UMLS CUI [1,2])
C0438186 (UMLS CUI [2])
C1516251 (UMLS CUI [3])
Renal Insufficiency Pre-existing Absent
Item
no pre-existing renal impairment not related to the disease
boolean
C1565489 (UMLS CUI [1,1])
C2347662 (UMLS CUI [1,2])
C0332197 (UMLS CUI [1,3])
Malignant Neoplasms Absent | Exception Basal cell carcinoma | Exception Cervix carcinoma TNM clinical staging
Item
no history of any other malignant disease with the exception of basal cell carcinoma and stage i cervical cancer
boolean
C0006826 (UMLS CUI [1,1])
C0332197 (UMLS CUI [1,2])
C1705847 (UMLS CUI [2,1])
C0007117 (UMLS CUI [2,2])
C1705847 (UMLS CUI [3,1])
C0302592 (UMLS CUI [3,2])
C3258246 (UMLS CUI [3,3])
Serology negative HIV
Item
negative hiv serology
boolean
C0919674 (UMLS CUI [1,1])
C0019682 (UMLS CUI [1,2])
Contraceptive methods As Needed
Item
effective contraception when justified
boolean
C0700589 (UMLS CUI [1,1])
C1720688 (UMLS CUI [1,2])
Timepoint Transplantation
Item
at the time of transplantation
boolean
C2348792 (UMLS CUI [1,1])
C0040732 (UMLS CUI [1,2])
WHO performance status scale
Item
good performance status (who score≤2)
boolean
C1298650 (UMLS CUI [1])
Creatinine measurement, serum
Item
creatinine≤170μmol/l and no ineligibility criteria for intensification
boolean
C0201976 (UMLS CUI [1])
Stem cells Harvest CD34 Quantity | Transplantation of autologous hematopoietic stem cell Quantity
Item
stem cells harvest ≥ 5x10e6 cd34/kg for 2 asct
boolean
C0038250 (UMLS CUI [1,1])
C1512335 (UMLS CUI [1,2])
C0054953 (UMLS CUI [1,3])
C1265611 (UMLS CUI [1,4])
C1831743 (UMLS CUI [2,1])
C1265611 (UMLS CUI [2,2])
Progressive Disease Absent
Item
absence of progressive disease before transplantation
boolean
C1335499 (UMLS CUI [1,1])
C0332197 (UMLS CUI [1,2])
Study Subject Participation Status Refusal to Participate
Item
known refusal of the subject to participate to the study
boolean
C2348568 (UMLS CUI [1,1])
C1136454 (UMLS CUI [1,2])
Pregnancy | Breast Feeding
Item
female subject who is pregnant or breast-feeding
boolean
C0032961 (UMLS CUI [1])
C0006147 (UMLS CUI [2])
Hypersensitivity Investigational New Drugs | Hypersensitivity Investigational New Drug Analogue | Hypersensitivity Investigational New Drug Excipient
Item
history of allergy to any of the study medications, their analogues, or excipients in the various formulations
boolean
C0020517 (UMLS CUI [1,1])
C0013230 (UMLS CUI [1,2])
C0020517 (UMLS CUI [2,1])
C0013230 (UMLS CUI [2,2])
C0243071 (UMLS CUI [2,3])
C0020517 (UMLS CUI [3,1])
C0013230 (UMLS CUI [3,2])
C0015237 (UMLS CUI [3,3])
Hepatic Insufficiency Main
Item
main liver insufficiency
boolean
C1306571 (UMLS CUI [1,1])
C1542147 (UMLS CUI [1,2])
Peripheral Neuropathy CTCAE Grades Clinical examination
Item
≥ grade 3 peripheral neuropathy on clinical examination within 14 days before enrollment
boolean
C0031117 (UMLS CUI [1,1])
C1516728 (UMLS CUI [1,2])
C1456356 (UMLS CUI [1,3])