written informed consent
Item
written informed consent
boolean
C0021430 (UMLS CUI [1])
nsclc
Item
patients with advanced non-small cell lung cancer (nsclc).
boolean
C0007131 (UMLS CUI [1,1])
C0205179 (UMLS CUI [1,2])
previous chemotherapy
Item
patients who have received one previous chemotherapy for nsclc.
boolean
C0392920 (UMLS CUI [1])
full recovery from previous chemotherapy
Item
full recovery from previous chemotherapy.
boolean
C2004454 (UMLS CUI [1,1])
C0392920 (UMLS CUI [1,2])
comorbidity
Item
presence of either measurable or non-measurable disease by radiologic study or physical examination.
boolean
C0009488 (UMLS CUI [1])
major surgery
Item
at least 3 weeks since last major surgery (a lesser period is acceptable if deemed in the best interest of the patient).
boolean
C0679637 (UMLS CUI [1])
recovered from any reversible side effects
Item
at least 24 hours since prior radiotherapy providing that marked bone marrow suppression is not expected. patients who have received radiotherapy must have recovered from any reversible side effects (e.g. nausea and vomiting).
boolean
C2826210 (UMLS CUI [1,1])
C0001688 (UMLS CUI [1,2])
C1522449 (UMLS CUI [1,3])
adequate bone marrow reserve and adequate kidney and liver function
Item
laboratory criteria: patients must have adequate bone marrow reserve and adequate kidney and liver function.
boolean
C0005953 (UMLS CUI [1,1])
C0205411 (UMLS CUI [1,2])
C0232804 (UMLS CUI [2,1])
C0205411 (UMLS CUI [2,2])
C0232741 (UMLS CUI [3,1])
C0205411 (UMLS CUI [3,2])
brain metastasis
Item
symptoms of brain metastasis (cancer spreading to the brain), requiring treatment with steroids.
boolean
C0220650 (UMLS CUI [1])
active infection
Item
active infection.
boolean
C0009450 (UMLS CUI [1])
comorbidity limiting study participation
Item
severe medical problems other than the diagnosis of nsclc, that would limit the ability of the patient to follow study guidelines or expose the patient to extreme risk.
boolean
C1321605 (UMLS CUI [1,1])
C0439801 (UMLS CUI [1,2])
C0009488 (UMLS CUI [1,3])
planned therapy
Item
ongoing or planned chemotherapy, immunotherapy, radiotherapy, or investigational therapy for the treatment of nsclc.
boolean
C0087111 (UMLS CUI [1,1])
C1301732 (UMLS CUI [1,2])
participation in another trial
Item
use of investigational drug within 30 days prior to the first dose of study medication.
boolean
C2348568 (UMLS CUI [1])
pregnant or lactating women
Item
women who are pregnant or lactating.
boolean
C0032961 (UMLS CUI [1,1])
C0006147 (UMLS CUI [1,2])
contraceptive use
Item
patients of child-bearing potential refusing to practice adequate birth control methods.
boolean
C1999124 (UMLS CUI [1])
conditions which might alter absorption
Item
patients with conditions which might alter absorption of an oral drug.
boolean
C0087111 (UMLS CUI [1,1])
C0521102 (UMLS CUI [1,2])
C0000854 (UMLS CUI [1,3])