Adenocarcinoma of prostate Resectable | Ductal adenocarcinoma of prostate
Item
patients with adenocarcinoma of the prostate that in the opinion of the surgeon is resectable. ductal adenocarcinoma of the prostate is included.
boolean
C0007112 (UMLS CUI [1,1])
C1514888 (UMLS CUI [1,2])
C0349672 (UMLS CUI [2])
Anesthesia Low Risk Radical prostatectomy | Radical prostatectomy agreement | Neoadjuvant Therapy
Item
all patients must be regarded as low anesthetic risk for radical prostatectomy and confirm their intention to undergo radical prostatectomy at the end of the neoadjuvant therapy.
boolean
C0002903 (UMLS CUI [1,1])
C3538919 (UMLS CUI [1,2])
C0194810 (UMLS CUI [1,3])
C0194810 (UMLS CUI [2,1])
C0680240 (UMLS CUI [2,2])
C0600558 (UMLS CUI [3])
High risk factors | AJCC tumor staging | Prostate specific antigen measurement | Gleason score | Adenocarcinoma
Item
all patients must have at least one of the following high-risk features: clinical or pathological t3 disease, or ct2c or psa>20ng/ml or gleason 8-10 adenocarcinoma or clinical t2b and psa>10ng/ml and gleason 7 adenocarcinoma. the 1992 ajcc staging system will be followed.
boolean
C1830377 (UMLS CUI [1])
C0441915 (UMLS CUI [2])
C0201544 (UMLS CUI [3])
C3203027 (UMLS CUI [4])
C0001418 (UMLS CUI [5])
Hormone Therapy | Ketoconazole
Item
prior hormonal therapy up to 2 months is permitted; no concurrent ketoconazole is permitted.
boolean
C0279025 (UMLS CUI [1])
C0022625 (UMLS CUI [2])
Bone Marrow function | Absolute neutrophil count Peripheral blood | Platelet Count measurement | Liver function | Serum total bilirubin measurement | Bilirubin Calculated
Item
patients must have adequate bone marrow function defined as an absolute peripheral granulocyte count of >/= 1,500/mm3 and platelet count of >/= 100,000/mm3; adequate hepatic function defined with a total bilirubin of </= 1.5 mg/dl and aspartate aminotransferase (ast or sgot)/alanine aminotransferase (alt or sgpt) </= 2 times the upper limits of normal; adequate renal function defined as serum creatinine clearance >/= 40 cc/min (measured or calculated).
boolean
C0005953 (UMLS CUI [1,1])
C0031843 (UMLS CUI [1,2])
C0948762 (UMLS CUI [2,1])
C0229664 (UMLS CUI [2,2])
C0032181 (UMLS CUI [3])
C0232741 (UMLS CUI [4])
C1278039 (UMLS CUI [5])
C0005437 (UMLS CUI [6,1])
C0444686 (UMLS CUI [6,2])
Informed Consent | Surgical Oncology Consultation | Medical oncology Consultation
Item
patients must sign a written informed consent form prior to treatment. all patients must have a surgical and medical oncology consult prior to signing informed consent.
boolean
C0021430 (UMLS CUI [1])
C1515090 (UMLS CUI [2,1])
C0009818 (UMLS CUI [2,2])
C0025098 (UMLS CUI [3,1])
C0009818 (UMLS CUI [3,2])
Small cell carcinoma of prostate | Sarcomatoid carcinoma of prostate
Item
patients with small cell or sarcomatoid prostate cancers are not eligible.
boolean
C1300585 (UMLS CUI [1])
C1335519 (UMLS CUI [2])
Neoplasm Metastasis Evidence Clinical | Neoplasm Metastasis Evidence Radiologic
Item
patients with clinical or radiological evidence of metastatic disease
boolean
C0027627 (UMLS CUI [1,1])
C3887511 (UMLS CUI [1,2])
C0205210 (UMLS CUI [1,3])
C0027627 (UMLS CUI [2,1])
C3887511 (UMLS CUI [2,2])
C0205483 (UMLS CUI [2,3])
Chemotherapy | Investigational New Drugs
Item
prior chemotherapy or experimental agents
boolean
C0392920 (UMLS CUI [1])
C0013230 (UMLS CUI [2])
INTERCURRENT INFECTION Severe
Item
patients with severe intercurrent infection.
boolean
C0240021 (UMLS CUI [1,1])
C0205082 (UMLS CUI [1,2])
Congestive heart failure New York Heart Association Classification | Angina, Unstable | Myocardial Infarction
Item
patients with the new york heart association (nyha) class iii/iv congestive heart failure, unstable angina or myocardial infarction (mi) in the last 6 months.
boolean
C0018802 (UMLS CUI [1,1])
C1275491 (UMLS CUI [1,2])
C0002965 (UMLS CUI [2])
C0027051 (UMLS CUI [3])
Medical contraindication Adrenal Cortex Hormones
Item
contraindications to corticosteroids.
boolean
C1301624 (UMLS CUI [1,1])
C0001617 (UMLS CUI [1,2])
Uncontrolled hypertension Severe | Diabetic - poor control | Lung disease Oxygen Dependent | Chronic liver disease | HIV Infection
Item
uncontrolled severe hypertension, uncontrolled diabetes mellitus, oxygen-dependent lung disease, chronic liver disease or human immunodeficiency virus (hiv) infection.
boolean
C1868885 (UMLS CUI [1,1])
C0205082 (UMLS CUI [1,2])
C0421258 (UMLS CUI [2])
C0024115 (UMLS CUI [3,1])
C0030054 (UMLS CUI [3,2])
C0851827 (UMLS CUI [3,3])
C0341439 (UMLS CUI [4])
C0019693 (UMLS CUI [5])
Malignant Neoplasms second | Skin carcinoma
Item
second malignancies (excluding non-melanoma skin cancer) unless disease-free for 3 years.
boolean
C0006826 (UMLS CUI [1,1])
C0205436 (UMLS CUI [1,2])
C0699893 (UMLS CUI [2])
Psychotic Disorder Informed Consent Unable | Mental handicap Informed Consent Unable | Informed Consent incompetent | Compliance behavior Unwilling
Item
overt psychosis, mental disability or otherwise incompetent to give informed consent or history of non-compliance.
boolean
C0033975 (UMLS CUI [1,1])
C0021430 (UMLS CUI [1,2])
C1299582 (UMLS CUI [1,3])
C1306341 (UMLS CUI [2,1])
C0021430 (UMLS CUI [2,2])
C1299582 (UMLS CUI [2,3])
C0021430 (UMLS CUI [3,1])
C0231190 (UMLS CUI [3,2])
C1321605 (UMLS CUI [4,1])
C0558080 (UMLS CUI [4,2])