Exclusion Criteria
Current Sirolimus- or Everolimus-intake
boolean
Instable graft function (creatinine clearance < 40 ml/min)
boolean
Graft rejection within the 3 previous months
boolean
Proteinuria > 800 mg/d
boolean
Non-controlled hyperlipidemia (Cholesterol >7,8 mmol/l, Triglycerides > 4)
boolean
Leucopenia < 2500/nl
boolean
Thrombocytopenia < 90/nl
boolean
Pregnancy or breastfeeding
boolean
Women of childbearing age without highly effective contraception (= defined as those which result in a low failure rate (i.e. less than 1 % per year))
boolean
Known allergy to macrolides
boolean
Current participation in other studies
boolean
Refusal to sign informed consent form
boolean
Neoplasm other than defined as inclusion criteria
boolean
All contraindications to SRL (see package insert, appendix)
boolean
Persons who are detained officially or legally to an official institute
boolean