Exclusion Criteria
Type 1 diabetes mellitus.
boolean
Insulin-dependent type 2 diabetes mellitus.
boolean
Treatment or history of treatment with any insulin formulation other than emergency for more than 2 weeks.
boolean
Treatment with other oral antidiabetic drugs in addition to metformin within the last 12 weeks.
boolean
Anamnestic history of hypersensitivity to the study drugs or to drugs with similar chemical structures.
boolean
Is required to take or intends to continue taking any disallowed medication, any prescription medication, herbal treatment or over-the counter medication that may interfere with evaluation of the study medication, including:
boolean
Heparin (and heparin-like drugs)
boolean
coumarin
boolean
phenprocoumon
boolean
hirudin
boolean
Protein C
boolean
Fondaparinux
boolean
antithrombin III
boolean
Peroxisome Proliferation Activating Receptor (gamma) agonists
boolean
Treatment within the last 12 weeks with:
boolean
fibrates
boolean
gemfibrozil
boolean
niacin
boolean
Rifampicin
boolean
Changes in dosage of any statin treatment to lower low-density lipoprotein within 2 weeks before study entry and during study participation interval.
boolean
Changes in dosage of any anticoagulant treatment with acetyl salicylic acid and/or clopidogrel within 2 weeks before study entry and during study participation interval.
boolean
Start of statin and/or anticoagulant treatment during study participation interval.
boolean
History of severe or multiple allergies and/ or acute severe infections.
boolean
Have had more than one unexplained episode of severe hypoglycemia (defined as requiring assistance of another person due to disabling hypoglycemia) within 6 months prior to screening visit.
boolean
Progressive fatal disease.
boolean
Any elective surgery during study participation.
boolean
History of drug or alcohol abuse within the last 5 years.
boolean
A history of significant cardiovascular (New York Heart Association stage I - IV), respiratory, gastrointestinal, hepatic (alanine aminotransferase and/or aspartate aminotransferase greater than 2.5 times the upper limit of the normal reference range), renal (serum creatinine > 1.2 mg/dL in women and > 1.5 mg/dL in men, glomerular filtration rate < 60 ml/min as estimated by the Cockroft-Gault formula), neurological, psychiatric and/or hematological disease as judged by the investigator, history of macular edema.
boolean
Blood donation within the last 30 days.
boolean