Non-smoker | Healthy Volunteers | High altitude pulmonary edema Resistant Patients Quantity | High altitude pulmonary edema susceptible Patients Quantity | Heart Disease Absent | Lung disease Absent | Asthma Absent | Clinical examination Complete | Safety laboratory measurement | Informed Consent
Item
20 non smoker healthy volunteers : 10 resistant to high-altitude pulmonary oedema and 10 susceptible subjects, without history of cardiac or pulmonary disease or asthma, after a complete clinical examination and safety laboratory measurements prior to randomization, and after giving informed written consent.
boolean
C0337672 (UMLS CUI [1])
C1708335 (UMLS CUI [2])
C0340100 (UMLS CUI [3,1])
C0332325 (UMLS CUI [3,2])
C0030705 (UMLS CUI [3,3])
C1265611 (UMLS CUI [3,4])
C0340100 (UMLS CUI [4,1])
C0220898 (UMLS CUI [4,2])
C0030705 (UMLS CUI [4,3])
C1265611 (UMLS CUI [4,4])
C0018799 (UMLS CUI [5,1])
C0332197 (UMLS CUI [5,2])
C0024115 (UMLS CUI [6,1])
C0332197 (UMLS CUI [6,2])
C0004096 (UMLS CUI [7,1])
C0332197 (UMLS CUI [7,2])
C1456356 (UMLS CUI [8,1])
C0205197 (UMLS CUI [8,2])
C0036043 (UMLS CUI [9,1])
C0681902 (UMLS CUI [9,2])
C0021430 (UMLS CUI [10])
Lung diseases | Asthma | Pulmonary Hypertension
Item
antecedent of lung disease notably with asthmatic antecedent or htap
boolean
C0024115 (UMLS CUI [1])
C0004096 (UMLS CUI [2])
C0020542 (UMLS CUI [3])
Heart Disease
Item
antecedent of heart disease
boolean
C0018799 (UMLS CUI [1])
Female genitalia
Item
female genital organ
boolean
C0017421 (UMLS CUI [1])
Systolic Pressure Post Rest Lengthened
Item
systolic blood pressure < 85 mmhg or > 160 mmhg after 5 minutes of lengthened rest.
boolean
C0871470 (UMLS CUI [1,1])
C0687676 (UMLS CUI [1,2])
C0035253 (UMLS CUI [1,3])
C0392744 (UMLS CUI [1,4])
Drug Allergy | Hypersensitivity Bosentan | Hypersensitivity Bosentan Tablet Excipient
Item
sentimentality in a medicine, in particular in a bosentan or in one of the excipients of the tablet.
boolean
C0013182 (UMLS CUI [1])
C0020517 (UMLS CUI [2,1])
C0252643 (UMLS CUI [2,2])
C0020517 (UMLS CUI [3,1])
C1253356 (UMLS CUI [3,2])
C0015237 (UMLS CUI [3,3])
Hepatic Insufficiency Moderate Child-Pugh Classification | Hepatic Insufficiency Severe Child-Pugh Classification | Pharmacokinetics | Transaminases Hepatic Serous | Aspartate aminotransferase increased | Alanine aminotransferase increased
Item
hepatic incapacity moderated to severe correspondent in the class b or c of the classification of child-pugh (cf pharmacokinetics) rate serous hepatic aminotransferases, aspartate aminotransferases( asat) and\or alanine aminotransférases ( alat), superior to 3 times the superior limit of the normal before the started of the treatment.
boolean
C1306571 (UMLS CUI [1,1])
C0205081 (UMLS CUI [1,2])
C4050412 (UMLS CUI [1,3])
C1306571 (UMLS CUI [2,1])
C0205082 (UMLS CUI [2,2])
C4050412 (UMLS CUI [2,3])
C0031328 (UMLS CUI [3])
C0002594 (UMLS CUI [4,1])
C0205054 (UMLS CUI [4,2])
C0440743 (UMLS CUI [4,3])
C0151904 (UMLS CUI [5])
C0151905 (UMLS CUI [6])
Systemic disease | Systemic disease chronic
Item
pointed or chronic systematic diseases.
boolean
C0442893 (UMLS CUI [1])
C0442893 (UMLS CUI [2,1])
C0205191 (UMLS CUI [2,2])
HIV antibody positive | Hepatitis C Antibodies Present | Hepatitis B surface antigen positive | Anti-HBc antibody positive | Smoking (tobacco) addiction
Item
presence of antibody anti-hiv, of anti-hvc antibody, antigens hbs and\or antibody anti-hbc. - active addiction to smoking.
boolean
C0920548 (UMLS CUI [1])
C0166049 (UMLS CUI [2,1])
C0150312 (UMLS CUI [2,2])
C0149709 (UMLS CUI [3])
C0262506 (UMLS CUI [4])
C0848323 (UMLS CUI [5])
Alcohol abuse | Toxin Abuse
Item
alcohol abuse and of toxins.
boolean
C0085762 (UMLS CUI [1])
C0040549 (UMLS CUI [2,1])
C1546935 (UMLS CUI [2,2])
Concomitant Agent
Item
taking of concomitant medicines except those allowed the chapter concomitant treatments.
boolean
C2347852 (UMLS CUI [1])
Physical Examination Signs Abnormal | Physical Examination Symptoms Abnormal | Physical Examination test results abnormal | High altitude pulmonary edema
Item
signs, symptoms or values of the biological examinations situated except the clinically acceptable values for healthy subjects with or without antecedent of opha.
boolean
C0031809 (UMLS CUI [1,1])
C0220912 (UMLS CUI [1,2])
C0205161 (UMLS CUI [1,3])
C0031809 (UMLS CUI [2,1])
C1457887 (UMLS CUI [2,2])
C0205161 (UMLS CUI [2,3])
C0031809 (UMLS CUI [3,1])
C0850610 (UMLS CUI [3,2])
C0340100 (UMLS CUI [4])
Tea intake Excessive | Coffee intake Excessive | CHOCOLATE INGESTION Excessive | Caffeine ingestion Excessive
Item
common(current) ingestion of excessive quantities of tea, coffee(cafe), chocolate and\or drinks containing some caffeine (> 5 cups / day, is approximately 500 mg of caffeine a day).
boolean
C0556161 (UMLS CUI [1,1])
C0442802 (UMLS CUI [1,2])
C0556160 (UMLS CUI [2,1])
C0442802 (UMLS CUI [2,2])
C0239052 (UMLS CUI [3,1])
C0442802 (UMLS CUI [3,2])
C0238877 (UMLS CUI [4,1])
C0442802 (UMLS CUI [4,2])
GRAPEFRUIT JUICE ST. JOHN'S WORT based | Herbal Tea ST. JOHN'S WORT based
Item
consumption of juice of grapefruit and\or herb tea on base of st.
boolean
C0452456 (UMLS CUI [1,1])
C0813171 (UMLS CUI [1,2])
C1705938 (UMLS CUI [1,3])
C0019233 (UMLS CUI [2,1])
C0813171 (UMLS CUI [2,2])
C1705938 (UMLS CUI [2,3])
ST. JOHN'S WORT
Item
john's wort
boolean
C0813171 (UMLS CUI [1])
Blood Donation
Item
don of blood in 3 months preceding the study.
boolean
C0005794 (UMLS CUI [1])
Study Subject Participation Status Exclusion
Item
persons in period of exclusion on the national file of the persons lending itself to the biomedical search(research) without direct individual profit.
boolean
C2348568 (UMLS CUI [1,1])
C2828389 (UMLS CUI [1,2])
Informed Consent Refused | Informed Consent Unable
Item
refusal or linguistic or psychic incapacity to sign the lit(enlightened) assent.
boolean
C0021430 (UMLS CUI [1,1])
C1705116 (UMLS CUI [1,2])
C0021430 (UMLS CUI [2,1])
C1299582 (UMLS CUI [2,2])
Protocol Compliance Unable
Item
subject which can not submit itself to the constraints of the protocol (for example, not cooperative, incapable to go(surrender) to the visits of follow-up and probably incapable to finish the study
boolean
C0525058 (UMLS CUI [1,1])
C1299582 (UMLS CUI [1,2])