CLL CD20 positive | Small Lymphocytic Lymphoma CD20 positive | Chemotherapy | Chemoimmunotherapy | Disease Progression Absent
Item
1. diagnosis of cd20+ chronic lymphocytic leukemia (cll) or small lymphocytic lymphoma (sll) treated with chemotherapy or chemoimmunotherapy: post-frontline therapy, patients must have non-progressing disease and be 4 months to 1 year post treatment. post-treatment for relapsed cll, eligible patients must have non-progressing disease and be 3 months to 1 year post treatment.
boolean
C0023434 (UMLS CUI [1,1])
C3888518 (UMLS CUI [1,2])
C0855095 (UMLS CUI [2,1])
C3888518 (UMLS CUI [2,2])
C0392920 (UMLS CUI [3])
C2986423 (UMLS CUI [4])
C0242656 (UMLS CUI [5,1])
C0332197 (UMLS CUI [5,2])
In complete remission | Nodular Partial Response | Partial response | Measurable Disease | Minimal residual disease Flow Cytometry
Item
2. patients (cr, npr, or pr at enrollment) must have measurable disease, which may include mrd by 4-color flow cytometry.
boolean
C0677874 (UMLS CUI [1])
C2347357 (UMLS CUI [2])
C1521726 (UMLS CUI [3])
C1513041 (UMLS CUI [4])
C0242596 (UMLS CUI [5,1])
C0016263 (UMLS CUI [5,2])
Renal function | Liver function | Creatinine measurement, serum | Serum total bilirubin measurement
Item
3. adequate renal and hepatic function (creatinine < 2 mg/dl, bilirubin < 2 mg/dl). patients with renal or liver dysfunction due to organ infiltration by lymphocytes may be eligible after discussion with the study chairman. patients with gilbert's syndrome are eligible.
boolean
C0232804 (UMLS CUI [1])
C0232741 (UMLS CUI [2])
C0201976 (UMLS CUI [3])
C1278039 (UMLS CUI [4])
Age
Item
4. age >/= 18 years.
boolean
C0001779 (UMLS CUI [1])
ECOG performance status
Item
5. ecog performance status of 0-2.
boolean
C1520224 (UMLS CUI [1])
Informed Consent
Item
6. provide informed consent indicating patient is aware of the investigational nature of this study according to the policies of the mdacc irb.
boolean
C0021430 (UMLS CUI [1])
Females & males of reproductive potential Contraceptive methods | Gender | Postmenopausal state Absent | Female Sterilization Absent | Male sterilization Absent
Item
7. patients of childbearing potential (females who have not been postmenopausal for at least 12 consecutive months or who have not undergone previous surgical sterilization or males who have not been surgically sterilized) must be willing to practice birth control during the study.
boolean
C4034483 (UMLS CUI [1,1])
C0700589 (UMLS CUI [1,2])
C0079399 (UMLS CUI [2])
C0232970 (UMLS CUI [3,1])
C0332197 (UMLS CUI [3,2])
C0015787 (UMLS CUI [4,1])
C0332197 (UMLS CUI [4,2])
C0024559 (UMLS CUI [5,1])
C0332197 (UMLS CUI [5,2])
Serology positive Hepatitis B Virus | Serum Hepatitis B Surface Antigen Test Positive
Item
1. positive serology for hepatitis b virus (hb) defined as a positive test for hbsag. in addition, if negative for hbsag but hbcab positive (regardless of hbsab status), a hb dna test will be performed and if positive the subject will be excluded.
boolean
C0242089 (UMLS CUI [1,1])
C0019169 (UMLS CUI [1,2])
C1254699 (UMLS CUI [2,1])
C1514241 (UMLS CUI [2,2])
Chemotherapy | Therapeutic radiology procedure | Immunotherapy | Monoclonal Antibodies
Item
2. concurrent chemotherapy, radiotherapy, or immunotherapy, including other monoclonal antibodies. localized radiotherapy to an area not comprising bone marrow function does not apply.
boolean
C0392920 (UMLS CUI [1])
C1522449 (UMLS CUI [2])
C0021083 (UMLS CUI [3])
C0003250 (UMLS CUI [4])
Communicable Disease | Illness Significant | Liver disease | Biliary System Disorder | Exception Cholelithiasis Asymptomatic | Exception Liver Involvement with CLL | Exception Chronic liver disease Stable
Item
3. active infection or significant medical illness, including current active hepatic or biliary disease (with exception of patients with asymptomatic gallstones, liver involved with cll or stable chronic liver disease per investigator assessment).
boolean
C0009450 (UMLS CUI [1])
C0221423 (UMLS CUI [2,1])
C0750502 (UMLS CUI [2,2])
C0023895 (UMLS CUI [3])
C3275124 (UMLS CUI [4])
C1705847 (UMLS CUI [5,1])
C0008350 (UMLS CUI [5,2])
C0231221 (UMLS CUI [5,3])
C1705847 (UMLS CUI [6,1])
C0023884 (UMLS CUI [6,2])
C1314939 (UMLS CUI [6,3])
C0023434 (UMLS CUI [6,4])
C1705847 (UMLS CUI [7,1])
C0341439 (UMLS CUI [7,2])
C0205360 (UMLS CUI [7,3])
Pregnancy | Breast Feeding
Item
4. pregnant and breastfeeding females are excluded.
boolean
C0032961 (UMLS CUI [1])
C0006147 (UMLS CUI [2])