Age
Item
women and men aged 18-55 years
boolean
C0001779 (UMLS CUI [1])
Moderate depressive episode | Severe depressive episode | Montgomery-Asberg Depression Rating Scale Questionnaire
Item
moderate to severe depressive episode according to icd10-criteria icd10:f32.1, f32.2, f33.1, f33.2) and madrs-sum value >=18 points
boolean
C0494398 (UMLS CUI [1])
C0494399 (UMLS CUI [2])
C4054475 (UMLS CUI [3])
Bipolar Disorder | Bipolar II disorder
Item
bipolar affective disorder incl. bd-ii.
boolean
C0005586 (UMLS CUI [1])
C0236788 (UMLS CUI [2])
Comorbidity Psychiatric | Comorbidity Neurologic
Item
psychiatric or neurologic comorbidity.
boolean
C0009488 (UMLS CUI [1,1])
C0205487 (UMLS CUI [1,2])
C0009488 (UMLS CUI [2,1])
C0205494 (UMLS CUI [2,2])
Depression, psychotic
Item
depression with psychotic symptoms.
boolean
C0743072 (UMLS CUI [1])
Pregnancy | Breast Feeding
Item
pregnancy or lactation period.
boolean
C0032961 (UMLS CUI [1])
C0006147 (UMLS CUI [2])
Cardiovascular Disease | Gastrointestinal Disease
Item
significant cardiovascular or gastrointestinal disease.
boolean
C0007222 (UMLS CUI [1])
C0017178 (UMLS CUI [2])
Liver Dysfunction Severe Child-Pugh Classification | Renal dysfunction Severe | Kidney Diseases Classification | Albuminuria
Item
severe dysfunction of liver (defined according to child-pugh-criteria (>=child a)) or kidney (defined according to kdigo stage i (albuminuria >=30mg/g).
boolean
C0086565 (UMLS CUI [1,1])
C0205082 (UMLS CUI [1,2])
C4050412 (UMLS CUI [1,3])
C3279454 (UMLS CUI [2,1])
C0205082 (UMLS CUI [2,2])
C0022658 (UMLS CUI [3,1])
C0008902 (UMLS CUI [3,2])
C0001925 (UMLS CUI [4])
Drug resistance
Item
known and proven pharmacoresistance.
boolean
C0013203 (UMLS CUI [1])
Medical contraindication Magnetic Resonance Imaging | Artificial cardiac pacemaker
Item
proven contraindication against mri (e.g. pacemaker).
boolean
C1301624 (UMLS CUI [1,1])
C0024485 (UMLS CUI [1,2])
C0030163 (UMLS CUI [2])
Incompatibility Investigational New Drugs
Item
known incompatibility against one of the substances used.
boolean
C0013184 (UMLS CUI [1,1])
C0013230 (UMLS CUI [1,2])
Monoamine Oxidase Inhibitors | Tranylcypromine
Item
intake of irreversible inhibitors of monoamine oxidase (maoi, e.g. tranylcypromine) during last 14 days.
boolean
C0026457 (UMLS CUI [1])
C0040778 (UMLS CUI [2])
Phenylketonuria
Item
known phenylketonuria.
boolean
C0031485 (UMLS CUI [1])
Childbearing Potential Contraceptive methods Missing | Contraceptive implant | Contraceptive injection | Combined Oral Contraceptives | Intrauterine Devices | Sexual Abstinence | Partner had vasectomy
Item
women with childbearing potential not using a highly effective method of birth control (e.g. implants, injectables, combined oral contraceptives, some iuds, sexual abstinence or vasectomised partner).
boolean
C3831118 (UMLS CUI [1,1])
C0700589 (UMLS CUI [1,2])
C1705492 (UMLS CUI [1,3])
C1657106 (UMLS CUI [2])
C1656586 (UMLS CUI [3])
C0009906 (UMLS CUI [4])
C0021900 (UMLS CUI [5])
C0036899 (UMLS CUI [6])
C0420842 (UMLS CUI [7])