Age
Item
1. age greater than or equal to 18 years
boolean
C0001779 (UMLS CUI [1])
Acute lymphocytic leukemia | Lymphoid leukemia | Chemotherapy | Berlin-Frankfort-Munster protocol Increased | hyperCVAD protocol | hyperCVAD protocol Variant
Item
2. newly diagnosed all or ll receiving chemotherapy with augmented bfm, hyper-cvad or any variant of hyper-cvad.
boolean
C0023449 (UMLS CUI [1])
C0023448 (UMLS CUI [2])
C0392920 (UMLS CUI [3])
C1135626 (UMLS CUI [4,1])
C0205217 (UMLS CUI [4,2])
C1742845 (UMLS CUI [5])
C1742845 (UMLS CUI [6,1])
C0205419 (UMLS CUI [6,2])
Childbearing Potential Contraceptive methods | Hysterectomy | Menstruation absent Month Quantity
Item
3. female patients of childbearing potential (i.e. no hysterectomy, no loss of menses for 12 consecutive months), must be willing to use contraception.
boolean
C3831118 (UMLS CUI [1,1])
C0700589 (UMLS CUI [1,2])
C0020699 (UMLS CUI [2])
C0497456 (UMLS CUI [3,1])
C0439231 (UMLS CUI [3,2])
C1265611 (UMLS CUI [3,3])
Gender Pregnancy test negative
Item
4. negative pregnancy test in female patients.
boolean
C0079399 (UMLS CUI [1,1])
C0427780 (UMLS CUI [1,2])
Enrollment | Induction Chemotherapy
Item
5. patients must be enrolled within 6 weeks of starting induction chemotherapy.
boolean
C1516879 (UMLS CUI [1])
C3179010 (UMLS CUI [2])
Hypocalcemia | Albumin level
Item
1. hypocalcemia of less than 8.4 (corrected to account for the albumin level, [see appendix e for formula])
boolean
C0020598 (UMLS CUI [1])
C0428519 (UMLS CUI [2])
Hypersensitivity Risedronate | Hypersensitivity Diphosphonates
Item
2. hypersensitivity to risedronate or other bisphosphonates
boolean
C0020517 (UMLS CUI [1,1])
C0246719 (UMLS CUI [1,2])
C0020517 (UMLS CUI [2,1])
C0012544 (UMLS CUI [2,2])
Unable to sit up Minute Quantity | unable to stand erect Minute Quantity
Item
3. inability to sit or stand upright for at least 30 minutes
boolean
C0560836 (UMLS CUI [1,1])
C0439232 (UMLS CUI [1,2])
C1265611 (UMLS CUI [1,3])
C2128578 (UMLS CUI [2,1])
C0439232 (UMLS CUI [2,2])
C1265611 (UMLS CUI [2,3])
Bone Density T score
Item
4. bone density t-score of -2.5 s.d or less.
boolean
C0005938 (UMLS CUI [1,1])
C3854607 (UMLS CUI [1,2])
Renal Insufficiency | Estimation of creatinine clearance by Cockcroft-Gault formula
Item
5. renal insufficiency (calculated creatinine clearance <30cc/min,[see appendix f for formula])
boolean
C1565489 (UMLS CUI [1])
C2711451 (UMLS CUI [2])
25-Hydroxyvitamin D Measurement | Osteomalacia Evidence of | Calcium ionised decreased | Parathyroid hormone concentration above normal range
Item
6. patients with a 25-hydroxyvitamin d concentration of less than 20 ng/ml and evidence of osteomalacia (low ionized calcium and high intact pth).
boolean
C2984945 (UMLS CUI [1])
C0029442 (UMLS CUI [2,1])
C0332120 (UMLS CUI [2,2])
C0855662 (UMLS CUI [3])
C0748089 (UMLS CUI [4])
Diphosphonates | Calcitonin | Anabolic steroids | Fluorides
Item
7. concomitant use of bisphosphonates, calcitonin, anabolic steroids, or fluoride.
boolean
C0012544 (UMLS CUI [1])
C0006668 (UMLS CUI [2])
C0002845 (UMLS CUI [3])
C0016327 (UMLS CUI [4])
Corrected serum calcium level | Cause Related lymphoma; leukemia | Hyperparathyroidism | Multiple Myeloma
Item
8. corrected calcium above 10.2, due to a cause not related to leukemia/lymphoma (i.e. hyperparathyroidism, multiple myeloma).
boolean
C1261202 (UMLS CUI [1])
C0015127 (UMLS CUI [2,1])
C0439849 (UMLS CUI [2,2])
C1402819 (UMLS CUI [2,3])
C0020502 (UMLS CUI [3])
C0026764 (UMLS CUI [4])