Age
Item
male or female, aged 18-65 years.
boolean
C0001779 (UMLS CUI [1])
Asthma treated by inhaled SABA | Astma treated by inhaled SABA plus low dose-medium dose ICS
Item
asthma treated by inhaled saba or inhaled saba plus low-medium dose ics in 6 weeks prior to randomisation.
boolean
C0004096 (UMLS CUI [1,1])
C0205535 (UMLS CUI [1,2])
C2917450 (UMLS CUI [1,3])
C0443303 (UMLS CUI [1,4])
C0004096 (UMLS CUI [2,1])
C0205535 (UMLS CUI [2,2])
C2917450 (UMLS CUI [2,3])
C0443303 (UMLS CUI [2,4])
C0332287 (UMLS CUI [2,5])
C2065041 (UMLS CUI [2,6])
C0445550 (UMLS CUI [2,7])
C0439536 (UMLS CUI [2,8])
Reliable history of moderate to severe rhinoconjunctivitis on exposure to grass
Item
a reliable history consistent with moderate to severe rhinoconjunctivitis on exposure to grass for at least the previous two grass seasons.
boolean
C0262926 (UMLS CUI [1,1])
C3858758 (UMLS CUI [1,2])
C0861154 (UMLS CUI [1,3])
C1299393 (UMLS CUI [1,4])
C0440307 (UMLS CUI [1,5])
Positive skin prick test to grass
Item
positive skin prick test to grass.
boolean
C0430561 (UMLS CUI [1,1])
C0440307 (UMLS CUI [1,2])
C1446409 (UMLS CUI [1,3])
Immunoglobulin E measurement, specific to grass pollen allergy
Item
grass-specific immunoglobulin e (ige) ≥ 0.35 ku/l.
boolean
C1270900 (UMLS CUI [1])
History of life-threatening asthma.
Item
history of life-threatening asthma.
boolean
C0004096 (UMLS CUI [1,1])
C2826244 (UMLS CUI [1,2])
C0262926 (UMLS CUI [1,3])
Uncontrolled asthma, Treatment adjusted per protocol
Item
uncontrolled asthma according to gina.
boolean
C0004096 (UMLS CUI [1,1])
C0205318 (UMLS CUI [1,2])
C1627778 (UMLS CUI [1,3])
Percent predicted FEV1
Item
fev1 of <70 % of predicted, regardless of the cause
boolean
C0730561 (UMLS CUI [1])
Administration of adrenaline is contraidicated
Item
administration of adrenaline (epinephrine) is contraindicated (e.g. subjects with acute or chronic symptomatic coronary heart disease).
boolean
C1301624 (UMLS CUI [1,1])
C0014563 (UMLS CUI [1,2])
History of severe drug allergy | Anaphylactic reaction to food.
Item
history of severe drug allergy or anaphylactic reaction to food.
boolean
C0262926 (UMLS CUI [1,1])
C0013182 (UMLS CUI [1,2])
C0205082 (UMLS CUI [1,3])
C0262926 (UMLS CUI [2,1])
C0685898 (UMLS CUI [2,2])
Medical history of any significant disease or disorder
Item
a history of any significant disease or disorder (e.g. immune system, pulmonary, cardiovascular, gastrointestinal, liver, renal, neurological, metabolic, malignant, psychiatric, major physical impairment, history of alcohol or drug abuse)
boolean
C0262926 (UMLS CUI [1,1])
C0012634 (UMLS CUI [1,2])
C2826293 (UMLS CUI [1,3])