Did the subject meet all the entry criteria?
Item
Did the subject meet all the entry criteria?
boolean
C1516637 (UMLS CUI [1])
Healthy; defined as individuals who are free of significant cardiac, pulmonary gastrointestinal, hepatic, renal, haematologic, neurological and psychiatric disease as determined by medical history, physical examination and clinical chemistry/haematology/urinalysis investigation.
Item
Healthy; defined as individuals who are free of significant cardiac, pulmonary gastrointestinal, hepatic, renal, haematologic, neurological and psychiatric disease as determined by medical history, physical examination and clinical chemistry/haematology/urinalysis investigation.
boolean
C3898900 (UMLS CUI [1])
C0018799 (UMLS CUI [2])
C0024115 (UMLS CUI [3])
C0017178 (UMLS CUI [4])
C0023895 (UMLS CUI [5])
C0022658 (UMLS CUI [6])
C0018939 (UMLS CUI [7])
C0027765 (UMLS CUI [8])
C0004936 (UMLS CUI [9])
C0262926 (UMLS CUI [10])
C0031809 (UMLS CUI [11])
C0008000 (UMLS CUI [12])
C0018941 (UMLS CUI [13])
C0042014 (UMLS CUI [14])
Male Gender, Self Report | Females; Childbearing Potential | Childbearing Potential; Absent | Tubal Ligation | Hysterectomy | Postmenopausal state
Item
Male or Female (non child bearing potential only). A female is eligible to enter and participate in the study if she is of non-childbearing potential (i.e., physiologically incapable of becoming pregnant defined as documented tubal ligation or hysterectomy), including any female who is post-menopausal. For the purposes of this study, post-menopausal is defined as 1 year without menses.
boolean
C1706180 (UMLS CUI [1])
C0086287 (UMLS CUI [2,1])
C3831118 (UMLS CUI [2,2])
C0520483 (UMLS CUI [3])
C0020699 (UMLS CUI [4])
C0232970 (UMLS CUI [5])
Aged 18-65 years
Item
Aged 18-65 years
boolean
C0001779 (UMLS CUI [1])
Body mass index within range of 19-31kg/m^2
Item
Body mass index within range of 19-31kg/m^2
boolean
C1305855 (UMLS CUI [1])
A non-smoker for at least the past 12 months with a pack history <= pack years
Item
A non-smoker for at least the past 12 months with a pack history <= pack years
boolean
C0337672 (UMLS CUI [1])
C1277691 (UMLS CUI [2])
Normal ECG at Screening
Item
Normal ECG at Screening
boolean
C0522054 (UMLS CUI [1])
Able to provide written informed consent
Item
Able to provide written informed consent
boolean
C0021430 (UMLS CUI [1])
Available to complete the study and all measurements
Item
Available to complete the study and all measurements
boolean
C1321605 (UMLS CUI [1])
Able to use the inhalation device satisfactorily
Item
Able to use the inhalation device satisfactorily
boolean
C0085732 (UMLS CUI [1,1])
C1524063 (UMLS CUI [1,2])
C0021461 (UMLS CUI [1,3])
As a result of medical interview, physical examination or screening investigations, the responsible physician deems the subject unsuitable for the study.
Item
As a result of medical interview, physical examination or screening investigations, the responsible physician deems the subject unsuitable for the study.
boolean
C0021822 (UMLS CUI [1])
C0031809 (UMLS CUI [2])
C0220908 (UMLS CUI [3,1])
C0841577 (UMLS CUI [3,2])
C3839996 (UMLS CUI [4])
The subject has a history of drug or other allergy, which, in the opinion of the responsible physician, contraindicates their participation
Item
The subject has a history of drug or other allergy, which, in the opinion of the responsible physician, contraindicates their participation
boolean
C0013182 (UMLS CUI [1])
C0020517 (UMLS CUI [2,1])
C0205394 (UMLS CUI [2,2])
C1301624 (UMLS CUI [3,1])
C0679823 (UMLS CUI [3,2])
The subject has a known hypersensitivity to corticosteroids or the excipients of GW685698X (lactose/COA)
Item
The subject has a known hypersensitivity to corticosteroids or the excipients of GW685698X (lactose/COA)
boolean
C0020517 (UMLS CUI [1,1])
C0001617 (UMLS CUI [1,2])
C0020517 (UMLS CUI [2,1])
C0015237 (UMLS CUI [2,2])
C0022949 (UMLS CUI [3])
The subject has participated in a study with a new molecular entity during the previous 12 days or any other trial during the previous 84 days
Item
The subject has participated in a study with a new molecular entity during the previous 112 days or any other trial during the previous 84 days
boolean
C2348568 (UMLS CUI [1])
The subject has donated a unit of blood within the previous 4 months or intends to donate within 4 months after completing the study.
Item
The subject has donated a unit of blood within the previous 4 months or intends to donate within 4 months after completing the study.
boolean
C0005794 (UMLS CUI [1])
The subject has taken oral corticosteroids less than 8 weeks before the screening visit.
Item
The subject has taken oral corticosteroids less than 8 weeks before the screening visit.
boolean
C0332185 (UMLS CUI [1,1])
C0442027 (UMLS CUI [1,2])
C0149783 (UMLS CUI [1,3])
The subject has taken inhaled, intranasal or topical steroids less than 4 weeks before the screening visit.
Item
The subject has taken inhaled, intranasal or topical steroids less than 4 weeks before the screening visit.
boolean
C2065041 (UMLS CUI [1,1])
C0332185 (UMLS CUI [1,2])
C0038317 (UMLS CUI [2,1])
C0001560 (UMLS CUI [2,2])
C0332185 (UMLS CUI [2,3])
C2064827 (UMLS CUI [3,1])
C0332185 (UMLS CUI [3,2])
The subject is currently taking regular (or a course of) medication whether prescribed or not, within 14 days of the first dose of study medication.
Item
The subject is currently taking regular (or a course of) medication whether prescribed or not, within 14 days of the first dose of study medication.
boolean
C0013227 (UMLS CUI [1,1])
C0205272 (UMLS CUI [1,2])
Drink on average more than 4 units of alcohol per day (3 units for females) and no more than 21 units of alcohol a week (14 units for females) (one unit=125mL wine or 25 mL spirits or 250mL normal strength lager).
Item
Drink on average more than 4 units of alcohol per day (3 units for females) and no more than 21 units of alcohol a week (14 units for females) (one unit=125mL wine or 25 mL spirits or 250mL normal strength lager).
boolean
C0001948 (UMLS CUI [1])
C0560578 (UMLS CUI [2])
C0560579 (UMLS CUI [3])
The subject has a history of breathing problems in adult life (i.e. history of asthmatic symptomatology).Screening lung function tests (FEV1 and PEFR) will be performed to confirm normal lung function parameters (>=90% predicted).
Item
The subject has a history of breathing problems in adult life (i.e. history of asthmatic symptomatology). Screening lung function tests (FEV1 and PEFR) will be performed to confirm normal lung function parameters (>=90% predicted).
boolean
C0262926 (UMLS CUI [1,1])
C0035203 (UMLS CUI [1,2])
C1254481 (UMLS CUI [1,3])
C0004096 (UMLS CUI [2,1])
C1457887 (UMLS CUI [2,2])
C0024119 (UMLS CUI [3,1])
C0220908 (UMLS CUI [3,2])
C0748133 (UMLS CUI [4])
The subject has been treated for or diagnosed with depression within six months of screening
Item
The subject has been treated for or diagnosed with depression within six months of screening
boolean
C0011581 (UMLS CUI [1])
The subject has tested positive for hepatitis C antibody or hepatitis B surface antigen (test to be taken within 3 months of study start).
Item
The subject has tested positive for hepatitis C antibody or hepatitis B surface antigen (test to be taken within 3 months of study start).
boolean
C0281863 (UMLS CUI [1])
C0149709 (UMLS CUI [2])
The subject has tested positive for HIV antibodies
Item
The subject has tested positive for HIV antibodies
boolean
C0019683 (UMLS CUI [1])
The subject has positive drugs of abuse test at screening or when randomly tested during the study.
Item
The subject has positive drugs of abuse test at screening or when randomly tested during the study.
boolean
C0373483 (UMLS CUI [1,1])
C1446409 (UMLS CUI [1,2])
The subject works night-shifts that may change pattern during the study.
Item
The subject works night-shifts that may change pattern during the study.
boolean
C0555008 (UMLS CUI [1])