Follicular Lymphoma Ann Arbor lymphoma staging system | Recurrent disease | Disease Progression | Treatment required
Item
subjects with histologically proven follicular lymphoma (grade 1, 2, or 3a), in clinical relapse/progression requiring treatment
boolean
C0024301 (UMLS CUI [1,1])
C0432516 (UMLS CUI [1,2])
C0277556 (UMLS CUI [2])
C0242656 (UMLS CUI [3])
C0332121 (UMLS CUI [4])
First line treatment | rituximab | R-CHOP Regimen | R-CVP Regimen | fludarabine | mitoxantrone | dexamethasone
Item
subjects must have had first line treatment consisting of rituximab with or without rituximab maintenance therapy (i.e. rituximab monotherapy, r-chop, r-cvp, r-fnd, etc)
boolean
C1708063 (UMLS CUI [1])
C0393022 (UMLS CUI [2])
C0393023 (UMLS CUI [3])
C1882520 (UMLS CUI [4])
C0059985 (UMLS CUI [5])
C0026259 (UMLS CUI [6])
C0011777 (UMLS CUI [7])
Exposure to Rituximab
Item
at least 4 months since last rituximab exposure
boolean
C0332157 (UMLS CUI [1,1])
C0393022 (UMLS CUI [1,2])
Prior Therapy Quantity | Transformation Follicular Lymphoma | Anthracyclines
Item
subjects may have had any number of prior treatment regimens. if enrolled with transformed follicular lymphoma, study subject must have had anthracycline in a previous regimen
boolean
C1514463 (UMLS CUI [1,1])
C1265611 (UMLS CUI [1,2])
C0040682 (UMLS CUI [2,1])
C0024301 (UMLS CUI [2,2])
C0282564 (UMLS CUI [3])
ECOG performance status
Item
eastern cooperative oncology group (ecog) performance status of 0-2
boolean
C1520224 (UMLS CUI [1])
Life Expectancy
Item
life expectancy of at least 12 months
boolean
C0023671 (UMLS CUI [1])
Lymph node Diameter | Amenable Excision
Item
presence of at least a 2x2 cm in diameter lymph node (either a single lymph node or combined volume of lymphoid tissue) accessible for excision; for histological confirmation of diagnosis and for manufacture of the vaccine
boolean
C0024204 (UMLS CUI [1,1])
C1301886 (UMLS CUI [1,2])
C3900053 (UMLS CUI [2,1])
C0728940 (UMLS CUI [2,2])
Measurable Disease Neck CT scan | Measurable Disease Chest CT scan | Measurable Disease Abdomen CT scan | Measurable Disease Pelvis CT scan | Response Chemotherapy
Item
measurable disease in neck, chest, abdomen, or pelvis as assessed by computed tomography (ct) scan such that response to 2nd line chemotherapy can be defined by the criteria of cheson et al (jco 2007; 25:579, see appendix 15.2 and ref 65). pet scan results are not required for enrollment
boolean
C1513041 (UMLS CUI [1,1])
C0027530 (UMLS CUI [1,2])
C0040405 (UMLS CUI [1,3])
C1513041 (UMLS CUI [2,1])
C0817096 (UMLS CUI [2,2])
C0040405 (UMLS CUI [2,3])
C1513041 (UMLS CUI [3,1])
C0000726 (UMLS CUI [3,2])
C0040405 (UMLS CUI [3,3])
C1513041 (UMLS CUI [4,1])
C0030797 (UMLS CUI [4,2])
C0040405 (UMLS CUI [4,3])
C1704632 (UMLS CUI [5,1])
C0392920 (UMLS CUI [5,2])
Exposure to Rituximab | Targeted Therapy Against CD20
Item
exposure to rituximab or anticd-20 directed therapy within the 4 months prior to enrollment
boolean
C0332157 (UMLS CUI [1,1])
C0393022 (UMLS CUI [1,2])
C2985566 (UMLS CUI [2,1])
C0521124 (UMLS CUI [2,2])
C0054946 (UMLS CUI [2,3])
HIV Infection | Hepatitis B | Hepatitis C
Item
history of human immunodeficiency virus (hiv), hepatitis b virus (hbv), or hepatitis c virus (hcv) infection
boolean
C0019693 (UMLS CUI [1])
C0019163 (UMLS CUI [2])
C0019196 (UMLS CUI [3])
Communicable Diseases Serious CTCAE Grades
Item
active clinically serious infections (> grade 2 national cancer institute common toxic criteria [nci-ctc] version 3.0)
boolean
C0009450 (UMLS CUI [1,1])
C0205404 (UMLS CUI [1,2])
C1516728 (UMLS CUI [1,3])
Metastatic malignant neoplasm to brain Symptomatic | Metastatic malignant neoplasm of meninges Symptomatic | Primary cerebral lymphoma | Meningeal Lymphoma
Item
symptomatic metastatic brain or meningeal tumors including lymphoma unless the patient is > 6 months from definitive therapy, has a negative imaging study within 4 weeks of study entry and is clinically stable with respect to the tumor at the time of study entry
boolean
C0220650 (UMLS CUI [1,1])
C0231220 (UMLS CUI [1,2])
C4302368 (UMLS CUI [2,1])
C0231220 (UMLS CUI [2,2])
C0240803 (UMLS CUI [3])
C2213017 (UMLS CUI [4])
Homologous Transplantation Organ
Item
history of organ allograft
boolean
C0040739 (UMLS CUI [1,1])
C0178784 (UMLS CUI [1,2])
Dialysis procedure
Item
patients undergoing renal dialysis
boolean
C0011946 (UMLS CUI [1])