Unresponsive to Treatment | Recurrent disease | Status post Therapeutic procedure Quantity
Item
refractory to or relapsed after at least 1 prior treatment line.
boolean
C0205269 (UMLS CUI [1])
C0277556 (UMLS CUI [2])
C0231290 (UMLS CUI [3,1])
C0087111 (UMLS CUI [3,2])
C1265611 (UMLS CUI [3,3])
ECOG performance status
Item
ecog performance status ≤2
boolean
C1520224 (UMLS CUI [1])
Age
Item
patients must be ≥18 years of age
boolean
C0001779 (UMLS CUI [1])
Informed Consent
Item
able to give a written informed consent.
boolean
C0021430 (UMLS CUI [1])
Cancer treatment | Palliative course of radiotherapy Limited
Item
any cancer therapy in the last 4 weeks or limited palliative radiation <2 weeks
boolean
C0920425 (UMLS CUI [1])
C0475092 (UMLS CUI [2,1])
C0439801 (UMLS CUI [2,2])
Hepatitis B | Hepatitis C | HIV Infection
Item
patients with hbv, hcv or hiv infection
boolean
C0019163 (UMLS CUI [1])
C0019196 (UMLS CUI [2])
C0019693 (UMLS CUI [3])
Autologous hematopoietic stem cell transplant | Allogeneic hematopoietic stem cell transplant
Item
autologous hematologic stem cell transplant within 3 months of study entry. allogeneic hematologic stem cell transplant within 12 months.
boolean
C2193200 (UMLS CUI [1])
C4255274 (UMLS CUI [2])
GS-1101 | CAL 101 | idelalisib | IPI-145 | TGR-1202 | Phosphatidylinositide 3-Kinase Inhibitor | mTOR Inhibitor | temsirolimus | everolimus | AKT Inhibitor | BTK Inhibitor | ibrutinib
Item
previous therapy with gs-1101 (cal-101, idelalisib), ipi-145, tgr-1202 or any drug that specifically inhibits pi3k/ mtor (including temsirolimus, everolimus), akt or btk inhibitor (including ibrutinib).
boolean
C3529624 (UMLS CUI [1])
C2703131 (UMLS CUI [2])
C2698692 (UMLS CUI [3])
C3274621 (UMLS CUI [4])
C3641791 (UMLS CUI [5])
C1519050 (UMLS CUI [6])
C2746052 (UMLS CUI [7])
C1707080 (UMLS CUI [8])
C0541315 (UMLS CUI [9])
C4744361 (UMLS CUI [10])
C4086017 (UMLS CUI [11])
C3501358 (UMLS CUI [12])
Therapeutic immunosuppression | CORTICOSTEROIDS FOR SYSTEMIC USE
Item
patients on immunosuppressive therapy including systemic corticosteroids.
boolean
C0021079 (UMLS CUI [1])
C3653708 (UMLS CUI [2])
Anticoagulation Therapy Systemic chronic | warfarin | sodium | heparin
Item
patients who are receiving chronic systemic anticoagulation therapy (warfarin sodium or heparin, etc.).
boolean
C0003281 (UMLS CUI [1,1])
C0205373 (UMLS CUI [1,2])
C0205191 (UMLS CUI [1,3])
C0043031 (UMLS CUI [2])
C0037473 (UMLS CUI [3])
C0019134 (UMLS CUI [4])
Liver disease
Item
patients with known history of liver disorders.
boolean
C0023895 (UMLS CUI [1])
Type 1 diabetes mellitus uncontrolled | Type II diabetes mellitus uncontrolled
Item
patients with uncontrolled diabetes type i or type ii
boolean
C2732402 (UMLS CUI [1])
C2733146 (UMLS CUI [2])
Other medical condition Severe Affecting Study Subject Participation Status | Other medical condition Uncontrolled Affecting Study Subject Participation Status | Condition Affecting Study Subject Participation Status
Item
any severe and/or uncontrolled medical conditions or other conditions that could affect their participation in the study.
boolean
C3843040 (UMLS CUI [1,1])
C0205082 (UMLS CUI [1,2])
C0392760 (UMLS CUI [1,3])
C2348568 (UMLS CUI [1,4])
C3843040 (UMLS CUI [2,1])
C0205318 (UMLS CUI [2,2])
C0392760 (UMLS CUI [2,3])
C2348568 (UMLS CUI [2,4])
C0348080 (UMLS CUI [3,1])
C0392760 (UMLS CUI [3,2])
C2348568 (UMLS CUI [3,3])
Pregnancy | Breast Feeding
Item
women who are pregnant or lactating.
boolean
C0032961 (UMLS CUI [1])
C0006147 (UMLS CUI [2])