Adult | Age
Item
adult patients, >/= 18 and </= 80 years of age at time of study inclusion
boolean
C0001675 (UMLS CUI [1])
C0001779 (UMLS CUI [2])
Diffuse Large B-Cell Lymphoma CD20 positive Untreated WHO tumor classification
Item
histologically confirmed, previously untreated cd20-positive diffuse large b-cell lymphoma (dlbcl) according to the who classification system
boolean
C0079744 (UMLS CUI [1,1])
C3888518 (UMLS CUI [1,2])
C0332155 (UMLS CUI [1,3])
C1301142 (UMLS CUI [1,4])
International Prognostic Index | Bulky Disease | Lesion Size Quantity
Item
patients with an international prognostic index (ipi) score 1-5, or ipi score 0 with bulky disease, defined as one lesion >/= 7.5 cm
boolean
C1512894 (UMLS CUI [1])
C1511341 (UMLS CUI [2])
C0221198 (UMLS CUI [3,1])
C0449453 (UMLS CUI [3,2])
C1265611 (UMLS CUI [3,3])
Measurable Disease 2-Dimensional Quantity | Lesion size, largest dimension CT | Lesion size, largest dimension PET scan | Lesion size, largest dimension MRI
Item
at least one bi-dimensionally measurable lesion defined as >/= 1.5 cm in its largest dimension on ct scan, pet-ct scan or mri
boolean
C1513041 (UMLS CUI [1,1])
C1705052 (UMLS CUI [1,2])
C1265611 (UMLS CUI [1,3])
C1275593 (UMLS CUI [2,1])
C0040405 (UMLS CUI [2,2])
C1275593 (UMLS CUI [3,1])
C0032743 (UMLS CUI [3,2])
C1275593 (UMLS CUI [4,1])
C0024485 (UMLS CUI [4,2])
Hematologic function
Item
adequate hematologic function
boolean
C0221130 (UMLS CUI [1])
ECOG performance status
Item
eastern cooperative oncology group (eocd) performance status </= 2
boolean
C1520224 (UMLS CUI [1])
Primary central nervous system lymphoma | Secondary Central Nervous System Lymphoma | Ttransformation Burkitt Lymphoma | Mediastinal (Thymic) Large B-Cell Lymphoma | Primary Effusion Lymphoma | Primary cutaneous diffuse large cell B-cell lymphoma | Large B-cell diffuse lymphoma of testis
Item
primary or secondary central nervous system lymphoma, histologic evidence of transformation to burkitt lymphoma, primary mediastinal dlbcl, primary effusion lymphoma, primary cutaneous dlbcl, or primary dlbcl of the testis
boolean
C0280803 (UMLS CUI [1])
C2981383 (UMLS CUI [2])
C0040682 (UMLS CUI [3,1])
C0006413 (UMLS CUI [3,2])
C1292754 (UMLS CUI [4])
C1292753 (UMLS CUI [5])
C1275325 (UMLS CUI [6])
C2057634 (UMLS CUI [7])
Transformation Lymphoma | Follicular Lymphoma Ann Arbor lymphoma staging system
Item
transformed lymphoma or follicular lymphoma iiib
boolean
C0040682 (UMLS CUI [1,1])
C0024299 (UMLS CUI [1,2])
C0024301 (UMLS CUI [2,1])
C0432516 (UMLS CUI [2,2])
Prior Therapy Diffuse Large B-Cell Lymphoma | Exception Biopsy of lymph node | Exception Therapeutic radiology procedure Local
Item
prior therapy for dlbcl, with the exception of nodal biopsy or local irradiation
boolean
C1514463 (UMLS CUI [1,1])
C0079744 (UMLS CUI [1,2])
C1705847 (UMLS CUI [2,1])
C0193842 (UMLS CUI [2,2])
C1705847 (UMLS CUI [3,1])
C1522449 (UMLS CUI [3,2])
C0205276 (UMLS CUI [3,3])
Cancer Other | Exception Curative treatment Basal cell carcinoma | Exception Curative treatment Squamous cell carcinoma | Exception Curative treatment Cutaneous Melanoma | Exception Curative treatment Carcinoma in situ of uterine cervix | Exception Malignant Neoplasm Remission Duration
Item
history of other malignancy, except for curatively treated basal or squamous cell carcinoma or melanoma of the skin, carcinoma in situ of the cervix, or a malignancy that has been treated without curative intent and has been in remission without treatment for >/= 5 years prior to enrolment
boolean
C1707251 (UMLS CUI [1])
C1705847 (UMLS CUI [2,1])
C1273390 (UMLS CUI [2,2])
C0007117 (UMLS CUI [2,3])
C1705847 (UMLS CUI [3,1])
C1273390 (UMLS CUI [3,2])
C0007137 (UMLS CUI [3,3])
C1705847 (UMLS CUI [4,1])
C1273390 (UMLS CUI [4,2])
C0151779 (UMLS CUI [4,3])
C1705847 (UMLS CUI [5,1])
C1273390 (UMLS CUI [5,2])
C0851140 (UMLS CUI [5,3])
C1705847 (UMLS CUI [6,1])
C0006826 (UMLS CUI [6,2])
C0687702 (UMLS CUI [6,3])
C0449238 (UMLS CUI [6,4])
Renal function Inadequate | Liver function Inadequate
Item
inadequate renal or hepatic function
boolean
C0232804 (UMLS CUI [1,1])
C0205412 (UMLS CUI [1,2])
C0232741 (UMLS CUI [2,1])
C0205412 (UMLS CUI [2,2])
HIV Infections | HIV Seropositivity
Item
known human immunodeficiency virus (hiv) infection or hiv seropositive status
boolean
C0019693 (UMLS CUI [1])
C0019699 (UMLS CUI [2])
Hepatitis B | Hepatitis C
Item
active hepatitis b virus (hbv) or active hepatitis c virus (hcv) infection. patients with occult or prior hbv infection as defined by protocol may be included. patients positive for hcv antibody are eligible only if polymerase chain reaction testing for hcv ribonucleic acid is negative.
boolean
C0019163 (UMLS CUI [1])
C0019196 (UMLS CUI [2])
Allergic Reaction Severe Humanized Monoclonal Antibodies | Anaphylaxis Severe Humanized Monoclonal Antibodies | Allergic Reaction Severe Monoclonal Antibodies Murine | Anaphylaxis Severe Monoclonal Antibodies Murine | Hypersensitivity Product Murine
Item
history of severe allergic or anaphylactic reactions to humanized or murine monoclonal antibodies or known sensitivity or allergy to murine products
boolean
C1527304 (UMLS CUI [1,1])
C0205082 (UMLS CUI [1,2])
C2985546 (UMLS CUI [1,3])
C0002792 (UMLS CUI [2,1])
C0205082 (UMLS CUI [2,2])
C2985546 (UMLS CUI [2,3])
C1527304 (UMLS CUI [3,1])
C0205082 (UMLS CUI [3,2])
C0003250 (UMLS CUI [3,3])
C0026809 (UMLS CUI [3,4])
C0002792 (UMLS CUI [4,1])
C0205082 (UMLS CUI [4,2])
C0003250 (UMLS CUI [4,3])
C0026809 (UMLS CUI [4,4])
C0020517 (UMLS CUI [5,1])
C1254351 (UMLS CUI [5,2])
C0026809 (UMLS CUI [5,3])
Medical contraindication Component CHOP regimen | Medical contraindication Anthracyclines
Item
contraindication to any of the individual components of chop, including prior receipt of anthracyclines
boolean
C1301624 (UMLS CUI [1,1])
C1705248 (UMLS CUI [1,2])
C0163868 (UMLS CUI [1,3])
C1301624 (UMLS CUI [2,1])
C0282564 (UMLS CUI [2,2])
Cytotoxic agent | rituximab | Anti-CD20 Antibody
Item
prior treatment with cytotoxic drugs or rituximab for another condition (e.g. rheumatoid arthritis) or prior use of an anti-cd20 antibody
boolean
C0304497 (UMLS CUI [1])
C0393022 (UMLS CUI [2])
C3891557 (UMLS CUI [3])
Pregnancy | Breast Feeding
Item
pregnant or lactating women
boolean
C0032961 (UMLS CUI [1])
C0006147 (UMLS CUI [2])