Age
Item
1. age >/=18 to </= 80 years of age.
boolean
C0001779 (UMLS CUI [1])
Non-Small Cell Lung Carcinoma TNM clinical staging Unresected | Non-Small Cell Adenocarcinoma | Squamous non-small cell lung cancer | Carcinoma, Large Cell
Item
2. unresected and pathologically (histologic) proven stage 3a or stage 3b nsclc of adenocarcinoma, squamous cell, large cell or mixed histology, diagnosed within three months of study randomization.
boolean
C0007131 (UMLS CUI [1,1])
C3258246 (UMLS CUI [1,2])
C2986425 (UMLS CUI [1,3])
C1335060 (UMLS CUI [2])
C4509816 (UMLS CUI [3])
C0206704 (UMLS CUI [4])
Disease Nonmetastatic Staging | Physical Examination | Chest CT | CT of upper abdomen | Nuclear magnetic resonance imaging brain | CT with Contrast | Whole body PET with CT with F-FDG
Item
3. non-metastatic disease staged by: physical examination, ct-chest and upper abdomen, brain mri or contrast-enhanced ct and whole body fluorodeoxyglucose (fdg)-pet/ct scan within two months of study randomization.
boolean
C0012634 (UMLS CUI [1,1])
C1518409 (UMLS CUI [1,2])
C0332305 (UMLS CUI [1,3])
C0031809 (UMLS CUI [2])
C0202823 (UMLS CUI [3])
C1627748 (UMLS CUI [4])
C4028269 (UMLS CUI [5])
C0742919 (UMLS CUI [6])
C4271885 (UMLS CUI [7])
ECOG performance status
Item
1. eastern cooperative oncology group (ecog) performance status >2.
boolean
C1520224 (UMLS CUI [1])
Weight loss Percentage Timespan
Item
2. more than 10% weight loss in the past 3 months.
boolean
C1262477 (UMLS CUI [1,1])
C0439165 (UMLS CUI [1,2])
C0872291 (UMLS CUI [1,3])
Patient Diabetic | metformin | Insulin | Hypoglycemic Agents
Item
3. diabetic patient or anyone currently taking metformin, insulin or other anti-hyperglycemic therapy.
boolean
C0030705 (UMLS CUI [1,1])
C0241863 (UMLS CUI [1,2])
C0025598 (UMLS CUI [2])
C0021641 (UMLS CUI [3])
C0020616 (UMLS CUI [4])
Pulmonary function tests | FEV1 | Percent predicted FEV1
Item
4. pulmonary function test (pfts) (within the last 12 weeks) with forced expiratory volume (fev)1 < 1.2 litres per second or less than 50% of predicted.
boolean
C0024119 (UMLS CUI [1])
C0849974 (UMLS CUI [2])
C0730561 (UMLS CUI [3])
Complete Blood Count | Renal function Chemistry profile | Liver function Chemistry profile | Chemotherapy Absence Required
Item
5. complete blood count (cbc) and biochemical renal and liver function profiles that do not permit chemotherapy treatment (as per institutional standard of care).
boolean
C0009555 (UMLS CUI [1])
C0232804 (UMLS CUI [2,1])
C0545265 (UMLS CUI [2,2])
C0232741 (UMLS CUI [3,1])
C0545265 (UMLS CUI [3,2])
C3665472 (UMLS CUI [4,1])
C0332197 (UMLS CUI [4,2])
C1514873 (UMLS CUI [4,3])
Fasting blood glucose measurement
Item
6. fasting blood sugar levels of >/= 7.0 mmol per litre.
boolean
C0428568 (UMLS CUI [1])
Systemic Chemotherapy Malignant neoplasm of lung
Item
7. prior systemic chemotherapy for lung cancer.
boolean
C1883256 (UMLS CUI [1,1])
C0242379 (UMLS CUI [1,2])
Prior Radiation Therapy | Overlap Treatment Area
Item
8. prior radiotherapy that would overlap with the planned treatment area.
boolean
C0279134 (UMLS CUI [1])
C1948020 (UMLS CUI [2,1])
C0087111 (UMLS CUI [2,2])
C0205146 (UMLS CUI [2,3])
Invasive Malignant Neoplasm | Exception Skin carcinoma | Exception Carcinoma in situ of female breast Non-invasive | Exception Oral cavity | Exception Malignant tumor of cervix
Item
9. prior invasive malignancy within the past 3 years (except non-melanomatous skin cancer non-invasive carcinoma in-situ of the breast, oral cavity or cervix).
boolean
C0677898 (UMLS CUI [1])
C1705847 (UMLS CUI [2,1])
C0699893 (UMLS CUI [2,2])
C1705847 (UMLS CUI [3,1])
C0686288 (UMLS CUI [3,2])
C0205303 (UMLS CUI [3,3])
C1705847 (UMLS CUI [4,1])
C0226896 (UMLS CUI [4,2])
C1705847 (UMLS CUI [5,1])
C0007847 (UMLS CUI [5,2])
AIDS
Item
10. known acquired immune deficiency syndrome (aids).
boolean
C0001175 (UMLS CUI [1])
High risk Lactic Acidosis
Item
11. patients with increased risk for lactic acidosis:
boolean
C4319571 (UMLS CUI [1,1])
C0001125 (UMLS CUI [1,2])
Congestive heart failure Severe New York Heart Association Classification
Item
severe congestive heart failure (nyha: class iii or iv),
boolean
C0018802 (UMLS CUI [1,1])
C0205082 (UMLS CUI [1,2])
C1275491 (UMLS CUI [1,3])
Metabolic acidosis
Item
history of metabolic acidosis,
boolean
C0220981 (UMLS CUI [1])
Alcohol consumption Drinks per day
Item
alcoholic intake of > 3 drinks daily,
boolean
C0001948 (UMLS CUI [1,1])
C0001967 (UMLS CUI [1,2])
C0439505 (UMLS CUI [1,3])
Liver disease Severe
Item
severe liver disease,
boolean
C0023895 (UMLS CUI [1,1])
C0205082 (UMLS CUI [1,2])
Kidney Failure
Item
renal failure
boolean
C0035078 (UMLS CUI [1])
Allergy to metformin
Item
12. known hypersensitivity or allergy to metformin.
boolean
C0571648 (UMLS CUI [1])
Pregnancy | Breast Feeding
Item
13. known pregnancy or lactating female patient.
boolean
C0032961 (UMLS CUI [1])
C0006147 (UMLS CUI [2])
Patient Unavailable Follow-up
Item
14. geographic inaccessibility for follow-up.
boolean
C0030705 (UMLS CUI [1,1])
C0686905 (UMLS CUI [1,2])
C3274571 (UMLS CUI [1,3])
Informed Consent Unable
Item
15. inability to provide informed consent.
boolean
C0021430 (UMLS CUI [1,1])
C1299582 (UMLS CUI [1,2])