Non-Small Cell Lung Carcinoma
Item
cytologic or histological diagnosis of non-small cell lung cancer
boolean
C0007131 (UMLS CUI [1])
Disease Progression | Status post Systemic Chemotherapy | Combined Modality Therapy | platinum | Patients EGFR mutation Untreated
Item
patients with disease progression after systemic chemotherapy with two-drug combination regimens that includes a platinum agent or patients with egfr mutation status who have not been treated
boolean
C0242656 (UMLS CUI [1])
C0231290 (UMLS CUI [2,1])
C1883256 (UMLS CUI [2,2])
C0009429 (UMLS CUI [3])
C0032207 (UMLS CUI [4])
C0030705 (UMLS CUI [5,1])
C3266992 (UMLS CUI [5,2])
C0332155 (UMLS CUI [5,3])
Metastatic malignant neoplasm to brain multiple
Item
patients are diagnosed with multiple brain metastases for the first time in 4 weeks
boolean
C0220650 (UMLS CUI [1,1])
C0439064 (UMLS CUI [1,2])
Metastatic malignant neoplasm to brain MRI
Item
diagnosis of brain metastases is made based on magnetic resonance imaging (mri).
boolean
C0220650 (UMLS CUI [1,1])
C0024485 (UMLS CUI [1,2])
Whole brain radiation therapy Benefit considered
Item
doctors consider the patient will benefit from wbrt
boolean
C1520143 (UMLS CUI [1,1])
C0814225 (UMLS CUI [1,2])
C0750591 (UMLS CUI [1,3])
Radiotherapy to brain Absent
Item
no prior brain radiotherapy
boolean
C0948319 (UMLS CUI [1,1])
C0332197 (UMLS CUI [1,2])
ECOG performance status
Item
ecog performance status 0-2
boolean
C1520224 (UMLS CUI [1])
Age
Item
age:18-75 years
boolean
C0001779 (UMLS CUI [1])
Neutrophil count | Platelet Count measurement | Hemoglobin measurement
Item
neutrophil count ≥1.5×10 to the 9th power/l and platelets≥100×10 to the 9th power/l. hemoglobin ≥90 g/l
boolean
C0200633 (UMLS CUI [1])
C0032181 (UMLS CUI [2])
C0518015 (UMLS CUI [3])
Liver function | Serum total bilirubin measurement | Alanine aminotransferase measurement | Aspartate aminotransferase measurement | Liver Involvement
Item
hepatic: total bilirubin less than or equal to 1.5 times upper limit of normal (uln) alanine transaminase (alt) and aspartate transaminase (ast) less than or equal to 2.5 times uln (or less than or equal to 5 times uln in case of known liver involvement)
boolean
C0232741 (UMLS CUI [1])
C1278039 (UMLS CUI [2])
C0201836 (UMLS CUI [3])
C0201899 (UMLS CUI [4])
C0023884 (UMLS CUI [5,1])
C1314939 (UMLS CUI [5,2])
Renal function | Creatinine measurement, serum
Item
renal: serum creatinine less than or equal to 1.5 times upper limit of normal (uln)
boolean
C0232804 (UMLS CUI [1])
C0201976 (UMLS CUI [2])
Metastatic malignant neoplasm to brain Measurable
Item
patients with measurable brain metastases according to the response evaluation criteria in solid tumors (recist) criteria
boolean
C0220650 (UMLS CUI [1,1])
C1513040 (UMLS CUI [1,2])
Informed Consent
Item
patients must sign an informed consent indicating that they are aware of the investigational nature of the study
boolean
C0021430 (UMLS CUI [1])
Radiotherapy to brain Previous
Item
prior brain radiation therapy
boolean
C0948319 (UMLS CUI [1,1])
C0205156 (UMLS CUI [1,2])
Metastatic malignant neoplasm to brain Solitary MRI
Item
solitary brain metastasis according to magnetic resonance imaging (mri)
boolean
C0220650 (UMLS CUI [1,1])
C0205171 (UMLS CUI [1,2])
C0024485 (UMLS CUI [1,3])
Metastatic Lesion Organ Extracranial Quantity
Item
mort than 3 extracranial organs have metastatic lesions
boolean
C1513183 (UMLS CUI [1,1])
C0178784 (UMLS CUI [1,2])
C0580586 (UMLS CUI [1,3])
C1265611 (UMLS CUI [1,4])
Prior Invasive Malignancy | Exception Basal cell carcinoma | Exception Carcinoma in situ of uterine cervix
Item
prior invasive malignancy (skin basal cell cancer, carcinoma in situ of cervix are permissible).
boolean
C4743663 (UMLS CUI [1])
C1705847 (UMLS CUI [2,1])
C0007117 (UMLS CUI [2,2])
C1705847 (UMLS CUI [3,1])
C0851140 (UMLS CUI [3,2])
Pregnancy | Breast Feeding
Item
pregnant or breast feeding women
boolean
C0032961 (UMLS CUI [1])
C0006147 (UMLS CUI [2])