Non-Small Cell Lung Carcinoma
Item
histologically confirmed non-small cell lung cancer
boolean
C0007131 (UMLS CUI [1])
Disease TNM clinical staging
Item
stage iiib or iv disease
boolean
C0012634 (UMLS CUI [1,1])
C3258246 (UMLS CUI [1,2])
Measurable Disease
Item
radiographically measurable disease
boolean
C1513041 (UMLS CUI [1])
Age
Item
18 and over
boolean
C0001779 (UMLS CUI [1])
ECOG performance status
Item
performance status: ecog 0-2
boolean
C1520224 (UMLS CUI [1])
Renal function | Creatinine measurement, serum
Item
renal: creatinine ≤ 2 mg/dl
boolean
C0232804 (UMLS CUI [1])
C0201976 (UMLS CUI [2])
Pregnancy test negative
Item
negative pregnancy test
boolean
C0427780 (UMLS CUI [1])
Females & males of reproductive potential Contraceptive methods
Item
fertile patients must use effective contraception
boolean
C4034483 (UMLS CUI [1,1])
C0700589 (UMLS CUI [1,2])
Prior Chemotherapy
Item
more than 4 weeks since prior chemotherapy
boolean
C1514457 (UMLS CUI [1])
Hormone Therapy | Adrenal Cortex Hormones Previous | Adrenal Cortex Hormones Absent | Adrenal Cortex Hormones chronic Absent | Exception Indication Topical steroids
Item
endocrine therapy: more than 4 weeks since prior corticosteroids; no concurrent corticosteroids, including chronic corticosteroids, except for medically-indicated topical steroids
boolean
C0279025 (UMLS CUI [1])
C0001617 (UMLS CUI [2,1])
C0205156 (UMLS CUI [2,2])
C0001617 (UMLS CUI [3,1])
C0332197 (UMLS CUI [3,2])
C0001617 (UMLS CUI [4,1])
C0205191 (UMLS CUI [4,2])
C0332197 (UMLS CUI [4,3])
C1705847 (UMLS CUI [5,1])
C3146298 (UMLS CUI [5,2])
C2064827 (UMLS CUI [5,3])
Therapeutic radiology procedure
Item
radiotherapy: more than 4 weeks since prior radiotherapy
boolean
C1522449 (UMLS CUI [1])
Cancer treatment Other
Item
more than 4 weeks since other prior anticancer therapy
boolean
C0920425 (UMLS CUI [1,1])
C0205394 (UMLS CUI [1,2])
Investigational New Drugs Previous | Exception Cytotoxic agent
Item
more than 4 weeks since prior non-cytotoxic investigational agents
boolean
C0013230 (UMLS CUI [1,1])
C0205156 (UMLS CUI [1,2])
C1705847 (UMLS CUI [2,1])
C0304497 (UMLS CUI [2,2])
Anti-Inflammatory Agents, Non-Steroidal
Item
at least 72 hours since prior nonsteroidal anti-inflammatory drugs (nsaids)
boolean
C0003211 (UMLS CUI [1])
Pregnancy | Breast Feeding
Item
pregnant or nursing
boolean
C0032961 (UMLS CUI [1])
C0006147 (UMLS CUI [2])
Comorbidity Excludes Investigational Therapy | Comorbidity Excludes Protocol Compliance | Mental condition Excludes Investigational Therapy | Mental condition Excludes Protocol Compliance | Chronic disease Excludes Investigational Therapy | Chronic disease Excludes Protocol Compliance | Laboratory test result abnormal Excludes Investigational Therapy | Laboratory test result abnormal Excludes Protocol Compliance
Item
comorbid disease, psychiatric condition, chronic medical condition, or laboratory abnormality that would preclude study treatment or compliance with study requirements
boolean
C0009488 (UMLS CUI [1,1])
C0332196 (UMLS CUI [1,2])
C0949266 (UMLS CUI [1,3])
C0009488 (UMLS CUI [2,1])
C0332196 (UMLS CUI [2,2])
C0525058 (UMLS CUI [2,3])
C3840291 (UMLS CUI [3,1])
C0332196 (UMLS CUI [3,2])
C0949266 (UMLS CUI [3,3])
C3840291 (UMLS CUI [4,1])
C0332196 (UMLS CUI [4,2])
C0525058 (UMLS CUI [4,3])
C0008679 (UMLS CUI [5,1])
C0332196 (UMLS CUI [5,2])
C0949266 (UMLS CUI [5,3])
C0008679 (UMLS CUI [6,1])
C0332196 (UMLS CUI [6,2])
C0525058 (UMLS CUI [6,3])
C0438215 (UMLS CUI [7,1])
C0332196 (UMLS CUI [7,2])
C0949266 (UMLS CUI [7,3])
C0438215 (UMLS CUI [8,1])
C0332196 (UMLS CUI [8,2])
C0525058 (UMLS CUI [8,3])
Hypersensitivity Celecoxib | Allergy to sulfonamide | Allergy to aspirin | Allergy to non-steroidal anti-inflammatory agent | Hypersensitivity Clinical Trial Reagents
Item
hypersensitivity to celecoxib, sulfonamides, aspirin, other nsaids, or any study reagent
boolean
C0020517 (UMLS CUI [1,1])
C0538927 (UMLS CUI [1,2])
C0038757 (UMLS CUI [2])
C0004058 (UMLS CUI [3])
C0570537 (UMLS CUI [4])
C0020517 (UMLS CUI [5,1])
C0008976 (UMLS CUI [5,2])
C0034760 (UMLS CUI [5,3])
Gastrointestinal ulcer | Gastrointestinal Hemorrhage | Gastrointestinal perforation
Item
history of gastrointestinal ulceration, bleeding, or perforation
boolean
C0237938 (UMLS CUI [1])
C0017181 (UMLS CUI [2])
C0151664 (UMLS CUI [3])
Cyclooxygenase 2 Inhibitors | Cox-3 inhibitor
Item
other concurrent cyclooxygenase-2 or -3 inhibitors
boolean
C1257954 (UMLS CUI [1])
C4722121 (UMLS CUI [2])
NSAIDs Other
Item
other concurrent nsaids
boolean
C0003211 (UMLS CUI [1,1])
C0205394 (UMLS CUI [1,2])