Liver carcinoma | Nodule of liver High risk | Alpha one fetoprotein measurement | Liver carcinoma pattern CT with Contrast | Liver carcinoma pattern MRI with contrast | Liver carcinoma pattern Angiography | Nodule size Liver Cirrhosis
Item
1. patients must have a diagnosis of hcc by at least one criterion listed below (klcsg guideline 2009) 1.1 pathologically (histologically or cytologically) proven diagnosis of hcc 1.2 liver nodule in high risk group 1.2.1 if alpha feto protein (afp)≥200 ng/ml , ≥ 1 typical hcc enhancing pattern on dynamic contrast enhanced ct or mri 1.2.2 if afp<200 ng/ml, ≥2 typical hcc enhancing pattern on dynamic contrast enhanced ct, mri, and angiography 1.3 ≥ 2 cm nodule in liver cirrhosis (lc), ≥ 1 typical hcc enhancing pattern on dynamic contrast enhanced ct or mri
boolean
C2239176 (UMLS CUI [1])
C0745761 (UMLS CUI [2,1])
C4319571 (UMLS CUI [2,2])
C0201539 (UMLS CUI [3])
C2239176 (UMLS CUI [4,1])
C0439712 (UMLS CUI [4,2])
C0742919 (UMLS CUI [4,3])
C2239176 (UMLS CUI [5,1])
C0439712 (UMLS CUI [5,2])
C0202671 (UMLS CUI [5,3])
C2239176 (UMLS CUI [6,1])
C0439712 (UMLS CUI [6,2])
C0002978 (UMLS CUI [6,3])
C0449457 (UMLS CUI [7,1])
C0023890 (UMLS CUI [7,2])
ECOG performance status
Item
2. eastern cooperative oncology group performance status 0 or 1
boolean
C1520224 (UMLS CUI [1])
Liver carcinoma Size
Item
3. size of the hcc ≤ 3 cm or less
boolean
C2239176 (UMLS CUI [1,1])
C0456389 (UMLS CUI [1,2])
Age
Item
4. age ≥ 20
boolean
C0001779 (UMLS CUI [1])
Patients Inappropriate Excision | Patients Inappropriate Transplantation | Patients Inappropriate Radiofrequency Ablation
Item
5. unsuitable for resection or transplant or rfa
boolean
C0030705 (UMLS CUI [1,1])
C1548788 (UMLS CUI [1,2])
C0728940 (UMLS CUI [1,3])
C0030705 (UMLS CUI [2,1])
C1548788 (UMLS CUI [2,2])
C0040732 (UMLS CUI [2,3])
C0030705 (UMLS CUI [3,1])
C1548788 (UMLS CUI [3,2])
C0850292 (UMLS CUI [3,3])
Patients Inappropriate Transarterial Chemoembolization | Unresponsive to Transarterial Chemoembolization | Patients Inappropriate Drug-eluting Embolic Bead
Item
6. unsuitable for or refractory to tace or drug eluting beads (deb)
boolean
C0030705 (UMLS CUI [1,1])
C1548788 (UMLS CUI [1,2])
C3539919 (UMLS CUI [1,3])
C0205269 (UMLS CUI [2,1])
C3539919 (UMLS CUI [2,2])
C0030705 (UMLS CUI [3,1])
C1548788 (UMLS CUI [3,2])
C3273294 (UMLS CUI [3,3])
Informed Consent
Item
7. agreement of study-specific informed consent
boolean
C0021430 (UMLS CUI [1])
Assessment Radiation Oncologist | Assessment Oncologist | Assessment Hepatologist
Item
8. assessment by radiation oncologist and medical oncologist or hepatologist within 28 days prior to study entry?
boolean
C1516048 (UMLS CUI [1,1])
C1514693 (UMLS CUI [1,2])
C1516048 (UMLS CUI [2,1])
C0259990 (UMLS CUI [2,2])
C1516048 (UMLS CUI [3,1])
C4280018 (UMLS CUI [3,2])
Child-Pugh Clinical Classification
Item
9. child-pugh score a within 14 days prior to study entry
boolean
C4050412 (UMLS CUI [1])
Liver normal Volume
Item
10. normal liver (liver minus gross tumor volume) ≥ 700 cc
boolean
C0577059 (UMLS CUI [1,1])
C0449468 (UMLS CUI [1,2])
Target Liver carcinoma
Item
11. target is only one viable hepatocellular carcinoma
boolean
C1521840 (UMLS CUI [1,1])
C2239176 (UMLS CUI [1,2])
Hematologic Test Required
Item
12. blood work requirements
boolean
C0018941 (UMLS CUI [1,1])
C1514873 (UMLS CUI [1,2])
Absolute neutrophil count | Platelet Count measurement | Hemoglobin measurement
Item
absolute neutrophil count (anc) ≥ 1,500 /mm3, platelet ≥ 70,000/mm3, hgb ≥ 8 g/dl
boolean
C0948762 (UMLS CUI [1])
C0032181 (UMLS CUI [2])
C0518015 (UMLS CUI [3])
Liver Function Tests | Serum total bilirubin measurement | International Normalized Ratio | Albumin measurement | Aspartate aminotransferase measurement | Alanine aminotransferase measurement
Item
liver function test (lft): t. bilirubin<3.0 mg/dl, international normalized ratio (inr) < 1.7, albumin ≥ 2.8g/dl, aspartate aminotransferase (ast)/alanine aminotransferase (alt)< 6 x normal
boolean
C0023901 (UMLS CUI [1])
C1278039 (UMLS CUI [2])
C0525032 (UMLS CUI [3])
C0201838 (UMLS CUI [4])
C0201899 (UMLS CUI [5])
C0201836 (UMLS CUI [6])
Creatinine measurement, serum | Creatinine clearance measurement
Item
serum creatinine < 1.5 x normal, or creatinine clearance rate ≥ 60 ml/min
boolean
C0201976 (UMLS CUI [1])
C0373595 (UMLS CUI [2])
Gender Contraceptive methods | Childbearing Potential Contraceptive methods
Item
13. male, consent contraception at least 6 months childbearing potential woman, consent contraception at least 6 months
boolean
C0079399 (UMLS CUI [1,1])
C0700589 (UMLS CUI [1,2])
C3831118 (UMLS CUI [2,1])
C0700589 (UMLS CUI [2,2])
Life Expectancy
Item
14. life expectancy more than 12 weeks
boolean
C0023671 (UMLS CUI [1])
Breathing Stable Duration
Item
15. stable breathing more than 10 minutes
boolean
C0004048 (UMLS CUI [1,1])
C0205360 (UMLS CUI [1,2])
C0449238 (UMLS CUI [1,3])
Fiducial marker placement
Item
16. consent to fiducial marker insertion ( if needed )
boolean
C3888577 (UMLS CUI [1])
Neoplasm Metastasis Extrahepatic | Lymph nodes Malignant Extrahepatic
Item
1. extrahepatic metastasis or malignant nodes
boolean
C0027627 (UMLS CUI [1,1])
C1517058 (UMLS CUI [1,2])
C0024204 (UMLS CUI [2,1])
C0205282 (UMLS CUI [2,2])
C1517058 (UMLS CUI [2,3])
Pregnancy | Breast Feeding
Item
2. pregnant and/or breastfeeding woman
boolean
C0032961 (UMLS CUI [1])
C0006147 (UMLS CUI [2])
Vascular Neoplasm macroscopic Involvement
Item
3. macroscopic vascular tumor involvement
boolean
C0027668 (UMLS CUI [1,1])
C0439806 (UMLS CUI [1,2])
C1314939 (UMLS CUI [1,3])
Therapeutic radiology procedure Upper abdomen
Item
4. previous upper abdominal rt history
boolean
C1522449 (UMLS CUI [1,1])
C0230165 (UMLS CUI [1,2])
Comorbidity Uncontrolled
Item
5. uncontrolled active co-morbidity
boolean
C0009488 (UMLS CUI [1,1])
C0205318 (UMLS CUI [1,2])