Core binding factor acute myeloid leukemia In complete remission First | t(8;21)(q22;q22) | AML1-ETO fusion protein, human | Other Coding | Acute myeloid leukemia with abnormal marrow eosinophils | t(16;16)(p13.1;q22) | Reverse Transcriptase Polymerase Chain Reaction | FISH | Karyotype determination procedure
Item
patients with cbf positive aml in cr1. cbf aml includes t(8;21)(q22;q22) [aml1(runx1)/eto(cbfα2t1)], inv(16)(q13q22) (cbfβ/myh11), t(16;16)(p13;q22) (cbfβ/myh11) using rt-pcr, fish, or standard karyotype analysis technique.
boolean
C3839741 (UMLS CUI [1,1])
C0677874 (UMLS CUI [1,2])
C0205435 (UMLS CUI [1,3])
C1515794 (UMLS CUI [2])
C0665119 (UMLS CUI [3])
C3846158 (UMLS CUI [4])
C0522630 (UMLS CUI [5])
C2828339 (UMLS CUI [6])
C0599161 (UMLS CUI [7])
C0162789 (UMLS CUI [8])
C0022526 (UMLS CUI [9])
Histone deacetylase inhibitor Chemotherapy cycle Planned
Item
patients who plan to receive the second cycle of hdac consolidation chemotherapy.
boolean
C4724018 (UMLS CUI [1,1])
C1302181 (UMLS CUI [1,2])
C1301732 (UMLS CUI [1,3])
Age
Item
15 years old or older and 65 years or younger
boolean
C0001779 (UMLS CUI [1])
Karnofsky Performance Status
Item
adequate performance status (karnofsky score of 70 or more).
boolean
C0206065 (UMLS CUI [1])
Liver function | Renal function | Aspartate aminotransferase measurement | Alanine aminotransferase measurement | Serum total bilirubin measurement | Creatinine measurement, serum
Item
adequate hepatic and renal function (ast, alt, and bilirubin < 3.0 x upper normal limit, and creatinine < 2.0 mg/dl).
boolean
C0232741 (UMLS CUI [1])
C0232804 (UMLS CUI [2])
C0201899 (UMLS CUI [3])
C0201836 (UMLS CUI [4])
C1278039 (UMLS CUI [5])
C0201976 (UMLS CUI [6])
Cardiac function | Left ventricular ejection fraction Heart scan | Left ventricular ejection fraction Echocardiography
Item
adequate cardiac function (left ventricular ejection fraction over 40% on heart scan or echocardiography)
boolean
C0232164 (UMLS CUI [1])
C0428772 (UMLS CUI [2,1])
C2500064 (UMLS CUI [2,2])
C0428772 (UMLS CUI [3,1])
C0013516 (UMLS CUI [3,2])
Informed Consent
Item
signed and dated informed consent must be obtained from patient.
boolean
C0021430 (UMLS CUI [1])
Communicable Disease Significant
Item
presence of significant active infection
boolean
C0009450 (UMLS CUI [1,1])
C0750502 (UMLS CUI [1,2])
Bleeding uncontrolled
Item
presence of uncontrolled bleeding
boolean
C3842135 (UMLS CUI [1])
Comorbidity Major | Organ failure
Item
any coexisting major illness or organ failure
boolean
C0009488 (UMLS CUI [1,1])
C0205164 (UMLS CUI [1,2])
C0349410 (UMLS CUI [2])
Mental disorders | Mental deficiency Severe | Treatment Compliance Unlikely | Informed Consent Unsuccessful
Item
patients with psychiatric disorder or mental deficiency severe as to make compliance with the treatment unlike, and making informed consent impossible
boolean
C0004936 (UMLS CUI [1])
C0917816 (UMLS CUI [2,1])
C0205082 (UMLS CUI [2,2])
C4319828 (UMLS CUI [3,1])
C0750558 (UMLS CUI [3,2])
C0021430 (UMLS CUI [4,1])
C1272705 (UMLS CUI [4,2])
Breast Feeding | Pregnancy | Childbearing Potential Contraceptive methods Unwilling
Item
nursing women, pregnant women, women of childbearing potential who do not want adequate contraception
boolean
C0006147 (UMLS CUI [1])
C0032961 (UMLS CUI [2])
C3831118 (UMLS CUI [3,1])
C0700589 (UMLS CUI [3,2])
C0558080 (UMLS CUI [3,3])
Malignant Neoplasm Previous | Exception Disease Free | Status post Curative treatment | Exception Curative treatment Skin carcinoma | Exception Curative treatment Carcinoma in Situ | Exception Curative treatment Cervical Intraepithelial Neoplasia
Item
patients with a diagnosis of prior malignancy unless disease-free for at least 5 years following therapy with curative intent (except curatively treated nonmelanoma skin cancer, in situ carcinoma, or cervical intraepithelial neoplasia)
boolean
C0006826 (UMLS CUI [1,1])
C0205156 (UMLS CUI [1,2])
C1705847 (UMLS CUI [2,1])
C0012634 (UMLS CUI [2,2])
C0332296 (UMLS CUI [2,3])
C0231290 (UMLS CUI [3,1])
C1273390 (UMLS CUI [3,2])
C1705847 (UMLS CUI [4,1])
C1273390 (UMLS CUI [4,2])
C0699893 (UMLS CUI [4,3])
C1705847 (UMLS CUI [5,1])
C1273390 (UMLS CUI [5,2])
C0007099 (UMLS CUI [5,3])
C1705847 (UMLS CUI [6,1])
C1273390 (UMLS CUI [6,2])
C0206708 (UMLS CUI [6,3])