Age
Item
1. age 18 to 70 years of age.
boolean
C0001779 (UMLS CUI [1])
Chronic Lymphocytic Leukemia | Prolymphocytic Leukemia | Richter's syndrome | Eligibility Allogeneic Transplantation
Item
2. patients with chronic lymphocytic leukemia, prolymphocytic leukemia, or richter's transformation who are eligible for allogeneic transplantation and are not eligible for protocols of higher priority.
boolean
C0023434 (UMLS CUI [1])
C0023486 (UMLS CUI [2])
C0349631 (UMLS CUI [3])
C1548635 (UMLS CUI [4,1])
C0040739 (UMLS CUI [4,2])
HLA Match Sibling | HLA Match Unrelated Donors
Item
3. a 10/10 hla matched (high resolution typing at a, b, c, drb1, dq1) sibling or unrelated donor.
boolean
C4330149 (UMLS CUI [1,1])
C0037047 (UMLS CUI [1,2])
C4330149 (UMLS CUI [2,1])
C3179133 (UMLS CUI [2,2])
Left ventricular ejection fraction
Item
4. left ventricular ef > 40%.
boolean
C0428772 (UMLS CUI [1])
FEV1 | FVC | DLCO
Item
5. fev1, fvc and corrected dlco > 40%.
boolean
C0849974 (UMLS CUI [1])
C3714541 (UMLS CUI [2])
C1516251 (UMLS CUI [3])
Creatinine measurement, serum | Serum total bilirubin measurement
Item
6. serum creatinine < 1.6 mg/dl. serum bilirubin < 2x upper limit of normal.
boolean
C0201976 (UMLS CUI [1])
C1278039 (UMLS CUI [2])
Alanine aminotransferase measurement
Item
7. sgpt < 2x upper limit of normal.
boolean
C0201836 (UMLS CUI [1])
Informed Consent
Item
8. voluntary signed, written irb-approved informed consent.
boolean
C0021430 (UMLS CUI [1])
Females & males of reproductive potential Contraceptive methods | Postmenopausal state | Female Sterilization | Gender Contraceptive methods | Contraceptives, Oral, Hormonal | Intrauterine Devices | Vaginal contraceptive diaphragm | Vaginal Spermicides | Female Condoms | Sexual Abstinence | Gender Contraceptive methods
Item
9. men and women of reproductive potential must agree to follow accepted birth control methods for the duration of the study. female subject is either post-menopausal or surgically sterilized or willing to use an acceptable method of birth control (i.e., a hormonal contraceptive, intra-uterine device, diaphragm with spermicide, condom with spermicide, or abstinence) for the duration of the study. male subject agrees to use an acceptable method for contraception for the duration of the study.
boolean
C4034483 (UMLS CUI [1,1])
C0700589 (UMLS CUI [1,2])
C0232970 (UMLS CUI [2])
C0015787 (UMLS CUI [3])
C0079399 (UMLS CUI [4,1])
C0700589 (UMLS CUI [4,2])
C0009907 (UMLS CUI [5])
C0021900 (UMLS CUI [6])
C0042241 (UMLS CUI [7])
C0087145 (UMLS CUI [8])
C0221829 (UMLS CUI [9])
C0036899 (UMLS CUI [10])
C0079399 (UMLS CUI [11,1])
C0700589 (UMLS CUI [11,2])
CNS disorder
Item
1. patient with active cns disease.
boolean
C0007682 (UMLS CUI [1])
Pregnancy | Serum pregnancy test (B-HCG) Positive | Breast Feeding
Item
2. pregnant (positive beta hcg test in a woman with child bearing potential defined as not post-menopausal for 12 months or no previous surgical sterilization) or currently breast-feeding. pregnancy testing is not required for post-menopausal or surgically sterilized women.
boolean
C0032961 (UMLS CUI [1])
C0430060 (UMLS CUI [2,1])
C1514241 (UMLS CUI [2,2])
C0006147 (UMLS CUI [3])
HIV Infection | HTLV-I Infection | Hepatitis B | Hepatitis C
Item
3. known infection with hiv, htlv-i, hepatitis b, or hepatitis c.
boolean
C0019693 (UMLS CUI [1])
C0020097 (UMLS CUI [2])
C0019163 (UMLS CUI [3])
C0019196 (UMLS CUI [4])
Bacterial Infections Uncontrolled | Virus Diseases Uncontrolled | Mycoses Uncontrolled
Item
4. active uncontrolled bacterial, viral or fungal infections.
boolean
C0004623 (UMLS CUI [1,1])
C0205318 (UMLS CUI [1,2])
C0042769 (UMLS CUI [2,1])
C0205318 (UMLS CUI [2,2])
C0026946 (UMLS CUI [3,1])
C0205318 (UMLS CUI [3,2])
Investigational New Drugs
Item
5. patient has received other investigational drugs within 2 weeks before enrollment.
boolean
C0013230 (UMLS CUI [1])