Age | Acute lymphocytic leukemia CD20 positive Untreated | Lymphoblastic Lymphoma | Burkitt Lymphoma | In complete remission Due to Induction Chemotherapy
Item
1. patients of all ages with newly diagnosed, previously untreated cd-20+ all, or lymphoblastic lymphoma, burkitt leukemia/lymphoma or having achieved cr with one course of induction chemotherapy.
boolean
C0001779 (UMLS CUI [1])
C0023449 (UMLS CUI [2,1])
C3888518 (UMLS CUI [2,2])
C0332155 (UMLS CUI [2,3])
C0855146 (UMLS CUI [3])
C0006413 (UMLS CUI [4])
C0677874 (UMLS CUI [5,1])
C0678226 (UMLS CUI [5,2])
C3179010 (UMLS CUI [5,3])
Induction Chemotherapy failed
Item
2. failure to one induction course of chemotherapy (these patients will be analyzed separately).
boolean
C3179010 (UMLS CUI [1,1])
C0231175 (UMLS CUI [1,2])
Performance status
Item
3. performance status of 0, 1, or 2.
boolean
C1518965 (UMLS CUI [1])
Organ function | Creatinine measurement, serum | Exception Neoplasm Related | Serum total bilirubin measurement | Exception Neoplasm Related
Item
4. adequate organ function with creatinine less than or equal to 3.0 mg/dl (unless considered tumor related), bilirubin less than or equal to 3.0 mg/dl (unless considered tumor related).
boolean
C0678852 (UMLS CUI [1])
C0201976 (UMLS CUI [2])
C1705847 (UMLS CUI [3,1])
C0027651 (UMLS CUI [3,2])
C0439849 (UMLS CUI [3,3])
C1278039 (UMLS CUI [4])
C1705847 (UMLS CUI [5,1])
C0027651 (UMLS CUI [5,2])
C0439849 (UMLS CUI [5,3])
Cardiac function | Cardiac Arrhythmia Absent | Myocardial Infarction Absent | Electrocardiogram abnormal Absent | Cardiac function Medical History | Cardiac function Physical Examination
Item
5. adequate cardiac function defined as no history of arrhythmia, history of mi or clinically significant abnormal ekg, as determined by the pi and/or the treating physician, within 3 months prior to study enrollment. cardiac function will be assessed by history and physical examination.
boolean
C0232164 (UMLS CUI [1])
C0003811 (UMLS CUI [2,1])
C0332197 (UMLS CUI [2,2])
C0027051 (UMLS CUI [3,1])
C0332197 (UMLS CUI [3,2])
C0522055 (UMLS CUI [4,1])
C0332197 (UMLS CUI [4,2])
C0232164 (UMLS CUI [5,1])
C0262926 (UMLS CUI [5,2])
C0232164 (UMLS CUI [6,1])
C0031809 (UMLS CUI [6,2])
Malignant Neoplasm Absent | Cancer Other Absent | Exception Acute lymphocytic leukemia | Exception Lymphoblastic Lymphoma | Life Expectancy Due to Malignant Neoplasm
Item
6. no active or co-existing malignancy(other than all or lymphoblastic lymphoma) with life expectancy less than 12 months due to that malignancy.
boolean
C0006826 (UMLS CUI [1,1])
C0332197 (UMLS CUI [1,2])
C1707251 (UMLS CUI [2,1])
C0332197 (UMLS CUI [2,2])
C1705847 (UMLS CUI [3,1])
C0023449 (UMLS CUI [3,2])
C1705847 (UMLS CUI [4,1])
C0855146 (UMLS CUI [4,2])
C0023671 (UMLS CUI [5,1])
C0678226 (UMLS CUI [5,2])
C0006826 (UMLS CUI [5,3])
Pregnancy | Breast Feeding
Item
1. pregnant or nursing women.
boolean
C0032961 (UMLS CUI [1])
C0006147 (UMLS CUI [2])
HIV Seropositivity
Item
2. known to be hiv+
boolean
C0019699 (UMLS CUI [1])
Philadelphia positive acute lymphocytic leukaemia
Item
3. ph+ all
boolean
C4524071 (UMLS CUI [1])
Disease Uncontrolled | Communicable Disease Uncontrolled
Item
4. active and uncontrolled disease/infection as judged by the treating physician
boolean
C0012634 (UMLS CUI [1,1])
C0205318 (UMLS CUI [1,2])
C0009450 (UMLS CUI [2,1])
C0205318 (UMLS CUI [2,2])
Informed Consent Unable | Informed Consent Unwilling
Item
5. unable or unwilling to sign the consent form
boolean
C0021430 (UMLS CUI [1,1])
C1299582 (UMLS CUI [1,2])
C0021430 (UMLS CUI [2,1])
C0558080 (UMLS CUI [2,2])
Liver disease | Biliary System Disorder | Exception Gilbert Disease | Exception Cholelithiasis Asymptomatic | Exception Secondary malignant neoplasm of liver | Exception Chronic liver disease Stable
Item
6. subjects who have current active hepatic or biliary disease (with exception of patients with gilbert's syndrome, asymptomatic gallstones, liver metastases or stable chronic liver disease per investigator assessment)
boolean
C0023895 (UMLS CUI [1])
C3275124 (UMLS CUI [2])
C1705847 (UMLS CUI [3,1])
C0017551 (UMLS CUI [3,2])
C1705847 (UMLS CUI [4,1])
C0008350 (UMLS CUI [4,2])
C0231221 (UMLS CUI [4,3])
C1705847 (UMLS CUI [5,1])
C0494165 (UMLS CUI [5,2])
C1705847 (UMLS CUI [6,1])
C0341439 (UMLS CUI [6,2])
C0205360 (UMLS CUI [6,3])
Drugs, Non-Prescription | Therapy, Investigational | Study Subject Participation Status | Interventional Study
Item
7. treatment with any known non - marketed drug substance or experimental therapy within 5 terminal half lives (calculated by multiplying the reported terminal half life by 5) or 4 weeks prior to enrollment, whichever is longer, or currently participating in any other interventional clinical study.
boolean
C0013231 (UMLS CUI [1])
C0949266 (UMLS CUI [2])
C2348568 (UMLS CUI [3])
C3274035 (UMLS CUI [4])
Cerebrovascular Disorder | Event with Symptoms | Event with Sequelae
Item
8. history of significant cerebrovascular disease in the past 6 months or ongoing event with active symptoms or sequelae
boolean
C0007820 (UMLS CUI [1])
C0441471 (UMLS CUI [2,1])
C0332287 (UMLS CUI [2,2])
C1457887 (UMLS CUI [2,3])
C0441471 (UMLS CUI [3,1])
C0332287 (UMLS CUI [3,2])
C0543419 (UMLS CUI [3,3])
Serology positive Hepatitis B | Hepatitis B surface antigen positive
Item
9. positive serology for hepatitis b (hb) defined as a positive test for hbsag. in addition, if negative for hbsag but hbcab positive (regardless of hbsab status), a hb dna test will be performed and if positive the subject will be excluded. consult with a physician experienced in care & management of subjects with hepatitis b to manage/treat subjects who are anti-hbc positive.
boolean
C0242089 (UMLS CUI [1,1])
C0019163 (UMLS CUI [1,2])
C0149709 (UMLS CUI [2])
Serology positive Hepatitis C | Hepatitis C antibody positive
Item
10. positive serology for hepatitis c (hc) defined as a positive test for hcab, in which case reflexively perform a hc riba immunoblot assay on the same sample to confirm the result.
boolean
C0242089 (UMLS CUI [1,1])
C0019196 (UMLS CUI [1,2])
C0281863 (UMLS CUI [2])