Age
Item
1. age >18
boolean
C0001779 (UMLS CUI [1])
Non-Small Cell Lung Carcinoma
Item
2. histologically or pathologically proven non-small cell lung cancer (nsclc)
boolean
C0007131 (UMLS CUI [1])
Meningeal Carcinomatosis | Cerebrospinal Fluid Cytology
Item
3. leptomeningeal carcinomatosis confirmed by csf cytology
boolean
C0220654 (UMLS CUI [1])
C0007806 (UMLS CUI [2,1])
C1305671 (UMLS CUI [2,2])
EGFR gene mutation | EGFR exon 19 deletion | EGFR L858R
Item
4. a patients with egfr mutation (including exon 19 deletion, l858r)
boolean
C3266992 (UMLS CUI [1])
C3889117 (UMLS CUI [2])
C3274204 (UMLS CUI [3])
ECOG performance status
Item
5. ecog performance status 0-3
boolean
C1520224 (UMLS CUI [1])
Life Expectancy
Item
6. expected life time more than at least 4 weeks
boolean
C0023671 (UMLS CUI [1])
Informed Consent
Item
7. a patients who signed the informed consent prior to the participation in the study
boolean
C0021430 (UMLS CUI [1])
Chemotherapy Absent
Item
8. chemotherapy-naïve patient is eligible
boolean
C0392920 (UMLS CUI [1,1])
C0332197 (UMLS CUI [1,2])
EGFR Tyrosine Kinase inhibitor | CNS metastases Absent
Item
9. previous egfr tki is allowed if this drug was not specifically used for cns metastases
boolean
C1443775 (UMLS CUI [1])
C0686377 (UMLS CUI [2,1])
C0332197 (UMLS CUI [2,2])
Pregnancy | Breast Feeding
Item
1. a pregnant or lactating patient
boolean
C0032961 (UMLS CUI [1])
C0006147 (UMLS CUI [2])
Childbearing Potential Pregnancy Tests Lacking | Childbearing Potential Pregnancy test positive
Item
2. a patient of childbearing potential without being tested for pregnancy at baseline or with a positive test. (a postmenopausal woman with the amenorrhea period of at least 12 months or longer is considered to have non-childbearing potential.)
boolean
C3831118 (UMLS CUI [1,1])
C0032976 (UMLS CUI [1,2])
C0332268 (UMLS CUI [1,3])
C3831118 (UMLS CUI [2,1])
C0240802 (UMLS CUI [2,2])
Females & males of reproductive potential Contraceptive methods Unwilling
Item
3. a man or woman of childbearing potential without the willingness to use a contraceptive measures during the study
boolean
C4034483 (UMLS CUI [1,1])
C0700589 (UMLS CUI [1,2])
C0558080 (UMLS CUI [1,3])
Cancer Other | Exception Curative treatment Basal cell carcinoma | Exception Curative treatment Carcinoma in situ of uterine cervix | Exception Curative treatment Early gastric cancer
Item
4. a patient with history of another malignant disease within past 3 years, except curatively treated basal cell carcinoma of the skin, cervical carcinoma in situ, and early gastric cancer
boolean
C1707251 (UMLS CUI [1])
C1705847 (UMLS CUI [2,1])
C1273390 (UMLS CUI [2,2])
C0007117 (UMLS CUI [2,3])
C1705847 (UMLS CUI [3,1])
C1273390 (UMLS CUI [3,2])
C0851140 (UMLS CUI [3,3])
C1705847 (UMLS CUI [4,1])
C1273390 (UMLS CUI [4,2])
C0349530 (UMLS CUI [4,3])
Lung Diseases, Interstitial | Exception Simple Lymphangitic metastasis to lung
Item
5. a patient with active interstitial lung disease, except simple lymphangitic lung metastasis
boolean
C0206062 (UMLS CUI [1])
C1705847 (UMLS CUI [2,1])
C2062926 (UMLS CUI [2,2])
C0205352 (UMLS CUI [2,3])
Allergic Reaction Gefitinib | Allergic Reaction Erlotinib
Item
6. a patient with history of allergic reaction to gefitinib or erlotinib
boolean
C1527304 (UMLS CUI [1,1])
C1122962 (UMLS CUI [1,2])
C1527304 (UMLS CUI [2,1])
C1135135 (UMLS CUI [2,2])
Laboratory test result
Item
7. the following laboratory test results:
boolean
C0587081 (UMLS CUI [1])
Absolute neutrophil count
Item
number of absolute neutrophils counts (anc) < 1.0ⅹ109/l
boolean
C0948762 (UMLS CUI [1])
Platelet Count measurement
Item
number of platelets < 50 ⅹ109/l
boolean
C0032181 (UMLS CUI [1])
Aspartate aminotransferase increased | Alanine aminotransferase increased
Item
ast, alt > 2.5 ⅹupper limit of normal
boolean
C0151904 (UMLS CUI [1])
C0151905 (UMLS CUI [2])
Elevated total bilirubin
Item
total bilirubin > 1.5 ⅹupper limit of normal
boolean
C0741494 (UMLS CUI [1])
Serum creatinine raised
Item
serum creatinine > 1.5 ⅹupper limit of normal
boolean
C0700225 (UMLS CUI [1])
Disease Serious
Item
8. a patient with serious disease as followings
boolean
C0012634 (UMLS CUI [1,1])
C0205404 (UMLS CUI [1,2])
Cardiac Arrhythmia Uncontrolled
Item
uncontrolled cardiac arrhythmia
boolean
C0003811 (UMLS CUI [1,1])
C0205318 (UMLS CUI [1,2])
Myocardial Infarction
Item
history of myocardial infarction within 6 months prior to the initiation of study
boolean
C0027051 (UMLS CUI [1])
Nervous system disorder | Mental disorders | Dementia | Seizures Uncontrolled
Item
neurological or psychiatric disorder including dementia or uncontrolled seizure
boolean
C0027765 (UMLS CUI [1])
C0004936 (UMLS CUI [2])
C0497327 (UMLS CUI [3])
C0036572 (UMLS CUI [4,1])
C0205318 (UMLS CUI [4,2])
Informed Consent Refused
Item
9. a patient who refused to sign the informed consent
boolean
C0021430 (UMLS CUI [1,1])
C1705116 (UMLS CUI [1,2])