Liver carcinoma | Tumor size | Liver Cirrhosis Imaging study | Hypervascular Phase Arterial | Washout Phase Portal vein | Washout Phase Delayed | Tumor Biopsy
Item
6.1.1. hcc diagnosed according to the aasld guideline1: tumor size > 1cm in a cirrhotic liver with typical appearance in one dynamic imaging study (hypervascular in the arterial phase with washout in the portal venous or delayed phase), or the tumor is biopsied.
boolean
C2239176 (UMLS CUI [1])
C0475440 (UMLS CUI [2])
C0023890 (UMLS CUI [3,1])
C1881134 (UMLS CUI [3,2])
C1512560 (UMLS CUI [4,1])
C0205390 (UMLS CUI [4,2])
C0221464 (UMLS CUI [4,3])
C1710661 (UMLS CUI [5,1])
C0205390 (UMLS CUI [5,2])
C0032718 (UMLS CUI [5,3])
C1710661 (UMLS CUI [6,1])
C0205390 (UMLS CUI [6,2])
C0205421 (UMLS CUI [6,3])
C0027651 (UMLS CUI [7,1])
C0005558 (UMLS CUI [7,2])
Operative Surgical Procedure Liver carcinoma | Measurable lesion Quantity | Age | Hepatitis B, Chronic | ECOG performance status | Life Expectancy | Child-Pugh Classification | Liver function Child-Pugh - Total Score | Alanine aminotransferase measurement | Aspartate aminotransferase measurement | Serum total bilirubin measurement | Creatinine measurement, serum
Item
6.1.2. patients who had undergone surgery for the treatment of hcc are allowed. 6.1.3. at least one measurable tumor, according to recist version 1.1. 6.1.4. age 18 years. 6.1.5. chronic hepatitis b. 6.1.6. ecog performance status 0 or 1. 6.1.7. life expectancy 2 months. 6.1.8. child-pugh class a or b liver function with a child-pugh score of ≦ 8. 6.1.9. liver transaminases (alt and ast) 300 iu/l; total bilirubin 2 mg/dl; serum creatinine 2 mg/dl.
boolean
C0543467 (UMLS CUI [1,1])
C2239176 (UMLS CUI [1,2])
C1513041 (UMLS CUI [2,1])
C1265611 (UMLS CUI [2,2])
C0001779 (UMLS CUI [3])
C0524909 (UMLS CUI [4])
C1520224 (UMLS CUI [5])
C0023671 (UMLS CUI [6])
C2347612 (UMLS CUI [7])
C0232741 (UMLS CUI [8,1])
C4055253 (UMLS CUI [8,2])
C0201836 (UMLS CUI [9])
C0201899 (UMLS CUI [10])
C1278039 (UMLS CUI [11])
C0201976 (UMLS CUI [12])
Criteria TACE Cohort | Neoplasms Lobe Single | Neoplasm Diameter Maximal
Item
6.1.10.specific criteria for the tace cohort: tumors distributed within one lobe and with maximal diameter of 10cm (for adequate amount of non-tumorous liver parenchyma for evaluation).
boolean
C0243161 (UMLS CUI [1,1])
C3539919 (UMLS CUI [1,2])
C0599755 (UMLS CUI [1,3])
C0027651 (UMLS CUI [2,1])
C0796494 (UMLS CUI [2,2])
C0205171 (UMLS CUI [2,3])
C0027651 (UMLS CUI [3,1])
C1301886 (UMLS CUI [3,2])
C0205289 (UMLS CUI [3,3])
Criteria Radiofrequency ablation Cohort | Neoplasm Single | Tumor size Diameter | Neoplasms Quantity | Tumor Approach Ultrasonic guidance procedure
Item
6.1.11.specific criteria for the rfa cohort: single tumor with size of less than 5cm in diameter or tumors 3 or less in number with size of less than 3cm in diameter. the target tumor(s) can be approached by ultrasound guidance.
boolean
C0243161 (UMLS CUI [1,1])
C0850292 (UMLS CUI [1,2])
C0599755 (UMLS CUI [1,3])
C0027651 (UMLS CUI [2,1])
C0205171 (UMLS CUI [2,2])
C0475440 (UMLS CUI [3,1])
C1301886 (UMLS CUI [3,2])
C0027651 (UMLS CUI [4,1])
C1265611 (UMLS CUI [4,2])
C0027651 (UMLS CUI [5,1])
C0449445 (UMLS CUI [5,2])
C0442973 (UMLS CUI [5,3])
Hepatitis C, Chronic | Diffuse Pattern Disease | Pattern Infiltrating Disease | TACE Previous Liver carcinoma | Hepatic artery thrombosis | Hepatic Vein Thrombosis | Portal vein thrombosis | Liver carcinoma Tumour rupture | Metastases Extrahepatic | Shunt intrahepatic | Surgical Portacaval Shunt | Medical contraindication Dynamic contrast-enhanced MRI | Contrast media allergy | Metallic implant | Claustrophobia
Item
6.2.1. chronic hepatitis c. 6.2.2. diffuse or infiltrative pattern of disease. 6.2.3. previous tace procedure for treatment of hcc. 6.2.4. hepatic artery, hepatic vein, or portal venous thrombosis. 6.2.5. history of hcc tumor rupture. 6.2.6. presence of extra-hepatic metastases. 6.2.7. documentation of large intrahepatic or portal-caval shunts. 6.2.8. contraindication for dce-mri, including known contrast allergy, electronically operated implants or devices, and claustrophobia.
boolean
C0524910 (UMLS CUI [1])
C1333299 (UMLS CUI [2,1])
C0012634 (UMLS CUI [2,2])
C0449774 (UMLS CUI [3,1])
C0332448 (UMLS CUI [3,2])
C0012634 (UMLS CUI [3,3])
C3539919 (UMLS CUI [4,1])
C0205156 (UMLS CUI [4,2])
C2239176 (UMLS CUI [4,3])
C0392106 (UMLS CUI [5])
C0019154 (UMLS CUI [6])
C0155773 (UMLS CUI [7])
C2239176 (UMLS CUI [8,1])
C2938957 (UMLS CUI [8,2])
C0027627 (UMLS CUI [9,1])
C1517058 (UMLS CUI [9,2])
C1442858 (UMLS CUI [10,1])
C1512948 (UMLS CUI [10,2])
C0032716 (UMLS CUI [11])
C1301624 (UMLS CUI [12,1])
C1831914 (UMLS CUI [12,2])
C0570562 (UMLS CUI [13])
C3693688 (UMLS CUI [14])
C0008909 (UMLS CUI [15])
Compliance behavior Unable MRI | Compliance behavior Unable Radiofrequency ablation
Item
6.2.9. unable to cooperate well with breath holding comments during mri examination or rfa treatment.
boolean
C1321605 (UMLS CUI [1,1])
C1299582 (UMLS CUI [1,2])
C0024485 (UMLS CUI [1,3])
C1321605 (UMLS CUI [2,1])
C1299582 (UMLS CUI [2,2])
C0850292 (UMLS CUI [2,3])
Systemic disease Major | Study Subject Participation Status Inappropriate
Item
6.2.10.major systemic diseases that the investigator considers inappropriate for participation.
boolean
C0442893 (UMLS CUI [1,1])
C0205164 (UMLS CUI [1,2])
C2348568 (UMLS CUI [2,1])
C1548788 (UMLS CUI [2,2])
Other medical condition Severe Study Subject Participation Status At risk | Severe Mental Disorders Study Subject Participation Status At risk | Chronic disease Study Subject Participation Status At risk | Chronic mental disorder Study Subject Participation Status At risk | Laboratory test result abnormal Study Subject Participation Status At risk | Other medical condition Severe Study Subject Participation Status Inappropriate | Severe Mental Disorders Study Subject Participation Status Inappropriate | Chronic disease Study Subject Participation Status Inappropriate | Chronic mental disorder Study Subject Participation Status Inappropriate | Laboratory test result abnormal Study Subject Participation Status Inappropriate
Item
6.2.11.other severe acute or chronic medical or psychiatric condition, or laboratory abnormality that may increase the risk associated with study participation and in the judgment of the investigator would make the patient inappropriate for entry into this study.
boolean
C3843040 (UMLS CUI [1,1])
C0205082 (UMLS CUI [1,2])
C2348568 (UMLS CUI [1,3])
C1444641 (UMLS CUI [1,4])
C4046029 (UMLS CUI [2,1])
C2348568 (UMLS CUI [2,2])
C1444641 (UMLS CUI [2,3])
C0008679 (UMLS CUI [3,1])
C2348568 (UMLS CUI [3,2])
C1444641 (UMLS CUI [3,3])
C0870281 (UMLS CUI [4,1])
C2348568 (UMLS CUI [4,2])
C1444641 (UMLS CUI [4,3])
C0438215 (UMLS CUI [5,1])
C2348568 (UMLS CUI [5,2])
C1444641 (UMLS CUI [5,3])
C3843040 (UMLS CUI [6,1])
C0205082 (UMLS CUI [6,2])
C2348568 (UMLS CUI [6,3])
C1548788 (UMLS CUI [6,4])
C4046029 (UMLS CUI [7,1])
C2348568 (UMLS CUI [7,2])
C1548788 (UMLS CUI [7,3])
C0008679 (UMLS CUI [8,1])
C2348568 (UMLS CUI [8,2])
C1548788 (UMLS CUI [8,3])
C0870281 (UMLS CUI [9,1])
C2348568 (UMLS CUI [9,2])
C1548788 (UMLS CUI [9,3])
C0438215 (UMLS CUI [10,1])
C2348568 (UMLS CUI [10,2])
C1548788 (UMLS CUI [10,3])
Abnormality of coagulation | Platelet Count measurement | Prothrombin time increased | International Normalized Ratio
Item
6.2.12.coagulation abnormality, including platelet count < 50000/l, prolongation of prothrombin time 5 seconds or inr >1.5) which could not be corrected by component therapy.
boolean
C1846821 (UMLS CUI [1])
C0032181 (UMLS CUI [2])
C0151872 (UMLS CUI [3])
C0525032 (UMLS CUI [4])
Ascites At risk Bleeding Complication | Cardiac Arrhythmia At risk Invasive procedure | Cardiac Arrhythmia At risk TACE | Cardiac Arrhythmia At risk Radiofrequency ablation
Item
6.2.13.obvious ascites which possibly cause bleeding complication. 6.2.14.history or clinically significant cardiac arrhythmia that is considered risky for invasive procedures including tace or rfa.
boolean
C0003962 (UMLS CUI [1,1])
C1444641 (UMLS CUI [1,2])
C0019080 (UMLS CUI [1,3])
C0009566 (UMLS CUI [1,4])
C0003811 (UMLS CUI [2,1])
C1444641 (UMLS CUI [2,2])
C4048276 (UMLS CUI [2,3])
C0003811 (UMLS CUI [3,1])
C1444641 (UMLS CUI [3,2])
C3539919 (UMLS CUI [3,3])
C0003811 (UMLS CUI [4,1])
C1444641 (UMLS CUI [4,2])
C0850292 (UMLS CUI [4,3])
Pregnancy | Breast Feeding
Item
6.2.15.woman who are pregnant or lactating.
boolean
C0032961 (UMLS CUI [1])
C0006147 (UMLS CUI [2])