Essential Hypertension Grade
Item
1. grade i or ii essential hypertension.
boolean
C0085580 (UMLS CUI [1,1])
C0441800 (UMLS CUI [1,2])
Sitting systolic blood pressure | Sitting diastolic blood pressure
Item
2. an office sitting systolic blood pressure of ≥ 150 and < 180 mmhg, and an office sitting diastolic blood pressure of ≥ 95 and < 110 mmhg during the placebo run-in period at week −2 and week 0.
boolean
C1319893 (UMLS CUI [1])
C1319894 (UMLS CUI [2])
Age | Informed Consent
Item
3. male or female aged 20 years or older at the time of providing informed consent.
boolean
C0001779 (UMLS CUI [1])
C0021430 (UMLS CUI [2])
Outpatient
Item
4. outpatient.
boolean
C0029921 (UMLS CUI [1])
Secondary hypertension | Hypertensive disease Grade | Malignant Hypertension
Item
1. secondary hypertension, grade iii hypertension or malignant hypertension.
boolean
C0155616 (UMLS CUI [1])
C0020538 (UMLS CUI [2,1])
C0441800 (UMLS CUI [2,2])
C0020540 (UMLS CUI [3])
Sitting systolic blood pressure | Sitting diastolic blood pressure | Combined Modality Therapy | Antihypertensive Agents Quantity
Item
2. an office sitting systolic blood pressure of ≥160 mmhg or sitting diastolic blood pressure of ≥100 mmhg recorded while on combined therapy with 3 or more antihypertensives within 4 weeks prior to the initiation of the placebo run-in period and at week −4.
boolean
C1319893 (UMLS CUI [1])
C1319894 (UMLS CUI [2])
C0009429 (UMLS CUI [3])
C0003364 (UMLS CUI [4,1])
C1265611 (UMLS CUI [4,2])
White Coat Hypertension | Other Coding | Night shift worker | Sleep Apnea Syndrome Treatment required for | Cardiovascular Disease | Cardiovascular symptoms
Item
3 evident white coat hypertension or white coat phenomenon. 4. day-night reversed lifestyle, such as night-time workers. 5. sleep apnea syndrome requiring treatment. 6. have any of the cardiovascular disease or symptoms listed below:
boolean
C0262534 (UMLS CUI [1])
C3846158 (UMLS CUI [2])
C0555008 (UMLS CUI [3])
C0037315 (UMLS CUI [4,1])
C0332121 (UMLS CUI [4,2])
C0007222 (UMLS CUI [5])
C0476270 (UMLS CUI [6])
Heart Disease | Myocardial Infarction | Coronary revascularisation | Valvular disease Severe | Atrial Fibrillation | Disease Requirement Pharmaceutical Preparations | Angina Pectoris | Congestive heart failure | Cardiac Arrhythmia
Item
heart disease: myocardial infarction (within 24 weeks before the placebo run-in period), coronary arterial revascularization (within 24 weeks before the placebo run-in period), severe valvular disease, atrial fibrillation, or following diseases which require medication: angina pectoris, congested heart failure, or arrhythmia.
boolean
C0018799 (UMLS CUI [1])
C0027051 (UMLS CUI [2])
C0877341 (UMLS CUI [3])
C3258293 (UMLS CUI [4,1])
C0205082 (UMLS CUI [4,2])
C0004238 (UMLS CUI [5])
C0012634 (UMLS CUI [6,1])
C1514873 (UMLS CUI [6,2])
C0013227 (UMLS CUI [6,3])
C0002962 (UMLS CUI [7])
C0018802 (UMLS CUI [8])
C0003811 (UMLS CUI [9])
Cerebrovascular Disorder | Cerebral Infarction | Cerebral Hemorrhage | Transient Ischemic Attack
Item
cerebrovascular disease: cerebral infarction, cerebral hemorrhage (within 24 weeks before the placebo run-in period), or transient ischemic attack (within 24 weeks before the placebo run-in period).
boolean
C0007820 (UMLS CUI [1])
C0007785 (UMLS CUI [2])
C2937358 (UMLS CUI [3])
C0007787 (UMLS CUI [4])
Vascular Diseases | Peripheral Arterial Disease | Intermittent Claudication | Arterial dissection | Aneurysm
Item
vascular diseases: peripheral arterial disease with intermittent claudication, artery dissection, aneurysm
boolean
C0042373 (UMLS CUI [1])
C1704436 (UMLS CUI [2])
C0021775 (UMLS CUI [3])
C0002949 (UMLS CUI [4])
C0002940 (UMLS CUI [5])
Hypertensive Retinopathy Advanced | Hemorrhage | Exudation | Papilledema
Item
advanced hypertensive retinopathy: bleeding, exudation, or papilledema (within 24 weeks before the placebo run-in period).
boolean
C0152132 (UMLS CUI [1,1])
C0205179 (UMLS CUI [1,2])
C0019080 (UMLS CUI [2])
C0311437 (UMLS CUI [3])
C0030353 (UMLS CUI [4])
Liver disease | Renal Insufficiency | Potassium low | Potassium increased | Sodium decreased | Sodium high | Complication Due to Gout | Gout | Complication Due to Hyperuricemia | Pharmaceutical Preparations Required
Item
7. clinically significant hepatic disorder. 8. clinically significant renal impairment. 9. significantly low or high potassium or sodium levels. 10. complicated by gout, or had a past history of gout within 24 weeks prior to the initiation of the placebo run-in period, or complicated by hyperuricemia requiring medication.
boolean
C0023895 (UMLS CUI [1])
C1565489 (UMLS CUI [2])
C0860866 (UMLS CUI [3])
C0856882 (UMLS CUI [4])
C0860871 (UMLS CUI [5])
C0595879 (UMLS CUI [6])
C0009566 (UMLS CUI [7,1])
C0678226 (UMLS CUI [7,2])
C0018099 (UMLS CUI [7,3])
C0018099 (UMLS CUI [8])
C0009566 (UMLS CUI [9,1])
C0678226 (UMLS CUI [9,2])
C0740394 (UMLS CUI [9,3])
C0013227 (UMLS CUI [10,1])
C1514873 (UMLS CUI [10,2])
Diabetic | Insulin regime | Type II diabetes mellitus uncontrolled
Item
11. diabetic subject on insulin treatment or poorly controlled type 2 diabetes mellitus.
boolean
C0241863 (UMLS CUI [1])
C0557978 (UMLS CUI [2])
C2733146 (UMLS CUI [3])
Malignant Neoplasm
Item
12. have a malignant tumor.
boolean
C0006826 (UMLS CUI [1])