Age | Atrial Fibrillation | Criteria Quantity Fulfill | Symptoms Clinical | Palpitations | Chest Pain | Dyspnea | Fatigue | Lightheadedness | Syncope | Atrial Fibrillation by ECG Finding | Atrial Fibrillation Newly Diagnosed Persistent | Recurrent atrial fibrillation Persistent
Item
male or female patients aged at least 18 years with atrial fibrillation (af) meeting at least one of the following criteria (a, b, c): a. acute clinical symptoms (like palpitations, chest pain, dyspnea, fatigue, lightheadedness, or syncope) for at least 48 hours and af on baseline ecg b. newly discovered af persisting for >=7 days c. recurrent af persisting for >=7 days
boolean
C0001779 (UMLS CUI [1])
C0004238 (UMLS CUI [2])
C0243161 (UMLS CUI [3,1])
C1265611 (UMLS CUI [3,2])
C1550543 (UMLS CUI [3,3])
C1457887 (UMLS CUI [4,1])
C0205210 (UMLS CUI [4,2])
C0030252 (UMLS CUI [5])
C0008031 (UMLS CUI [6])
C0013404 (UMLS CUI [7])
C0015672 (UMLS CUI [8])
C0220870 (UMLS CUI [9])
C0039070 (UMLS CUI [10])
C0344434 (UMLS CUI [11])
C0004238 (UMLS CUI [12,1])
C1518321 (UMLS CUI [12,2])
C0205322 (UMLS CUI [12,3])
C0741282 (UMLS CUI [13,1])
C0205322 (UMLS CUI [13,2])
Sinus rhythm Absent Electrocardiography
Item
no documented sinus rhythm on ecg for more than 1 year
boolean
C0232201 (UMLS CUI [1,1])
C0332197 (UMLS CUI [1,2])
C1623258 (UMLS CUI [1,3])
Neurologic Deficits | Transient Ischemic Attack | Cerebrovascular accident | Intracranial Hemorrhages | Disease Causing Neurologic Deficits | Multiple Sclerosis | Epilepsy
Item
acute neurological deficits (tia, stroke, intracranial bleeding), or known disease which may cause neurological deficits (e.g., multiple sclerosis, seizure disorder)
boolean
C0521654 (UMLS CUI [1])
C0007787 (UMLS CUI [2])
C0038454 (UMLS CUI [3])
C0151699 (UMLS CUI [4])
C0012634 (UMLS CUI [5,1])
C0678227 (UMLS CUI [5,2])
C0521654 (UMLS CUI [5,3])
C0026769 (UMLS CUI [6])
C0014544 (UMLS CUI [7])
Fibrinolytic Agents | Anticoagulation Therapy Low dose
Item
treatment with antithrombotic agents, including low-dose anticoagulation, for more than 48 hours prior to randomisation
boolean
C0016018 (UMLS CUI [1])
C0003281 (UMLS CUI [2,1])
C0445550 (UMLS CUI [2,2])
NSAIDs Oral Dose U/day | Aspirin Dose U/day
Item
treatment with oral nsaids or asa at doses greater than 325 mg per day for more than 72 hours prior to randomisation
boolean
C0003211 (UMLS CUI [1,1])
C1527415 (UMLS CUI [1,2])
C0178602 (UMLS CUI [1,3])
C0456683 (UMLS CUI [1,4])
C0004057 (UMLS CUI [2,1])
C0178602 (UMLS CUI [2,2])
C0456683 (UMLS CUI [2,3])
Anticoagulant therapy Required
Item
anticoagulant therapy required or likely to be required during the study period
boolean
C0150457 (UMLS CUI [1,1])
C1514873 (UMLS CUI [1,2])
Aspirin Dose U/day | Non-Steroidal Anti-Inflammatory Agents Oral
Item
treatment with asa at a dose greater than 325 mg per day or oral nsaids (at any dose) required or likely to be required during the study period
boolean
C0004057 (UMLS CUI [1,1])
C0178602 (UMLS CUI [1,2])
C0456683 (UMLS CUI [1,3])
C0003211 (UMLS CUI [2,1])
C1527415 (UMLS CUI [2,2])
Antiplatelet Agents Quantity | clopidogrel | Aspirin
Item
treatment with two or more antiplatelet agents (e.g. clopidogrel and asa) at any dose at the same time (i.e., within 24 hours)
boolean
C0085826 (UMLS CUI [1,1])
C1265611 (UMLS CUI [1,2])
C0070166 (UMLS CUI [2])
C0004057 (UMLS CUI [3])
Heparin allergy | Hypersensitivity Vitamin K Antagonist | Hypersensitivity Fondaparinux | Hypersensitivity Excipient Unfractionated heparin | Hypersensitivity Excipient Vitamin K Antagonist | Hypersensitivity Excipient Fondaparinux
Item
known hypersensitivity to ufh, vka, or fondaparinux or one of these drugs' excipients
boolean
C0571776 (UMLS CUI [1])
C0020517 (UMLS CUI [2,1])
C2267235 (UMLS CUI [2,2])
C0020517 (UMLS CUI [3,1])
C1098510 (UMLS CUI [3,2])
C0020517 (UMLS CUI [4,1])
C0015237 (UMLS CUI [4,2])
C0019134 (UMLS CUI [4,3])
C0020517 (UMLS CUI [5,1])
C0015237 (UMLS CUI [5,2])
C2267235 (UMLS CUI [5,3])
C0020517 (UMLS CUI [6,1])
C0015237 (UMLS CUI [6,2])
C1098510 (UMLS CUI [6,3])
BLEEDING ACTIVE Clinical Significance | Hemorrhage Clinical Significance
Item
active, clinically significant bleeding or clinically significant bleeding within the past month
boolean
C0741554 (UMLS CUI [1,1])
C2826293 (UMLS CUI [1,2])
C0019080 (UMLS CUI [2,1])
C2826293 (UMLS CUI [2,2])
Major surgery
Item
major surgery within the previous three months
boolean
C0679637 (UMLS CUI [1])
Uncontrolled hypertension | Systolic Pressure Persistent | Diastolic blood pressure Persistent
Item
uncontrolled arterial hypertension (persistent systolic blood pressure over 180 mm hg or diastolic blood pressure over 110 mm hg)
boolean
C1868885 (UMLS CUI [1])
C0871470 (UMLS CUI [2,1])
C0205322 (UMLS CUI [2,2])
C0428883 (UMLS CUI [3,1])
C0205322 (UMLS CUI [3,2])
Bacterial Endocarditis
Item
bacterial endocarditis
boolean
C0014121 (UMLS CUI [1])
Estimation of creatinine clearance by Cockcroft-Gault formula
Item
calculated creatinine clearance < 30 ml/min
boolean
C2711451 (UMLS CUI [1])
Body Weight
Item
body weight < 50 kg
boolean
C0005910 (UMLS CUI [1])
Operative Surgical Procedure Planned | Intervention Planned
Item
planned surgery or intervention within the next 65 days
boolean
C0543467 (UMLS CUI [1,1])
C1301732 (UMLS CUI [1,2])
C0184661 (UMLS CUI [2,1])
C1301732 (UMLS CUI [2,2])