Informed Consent
Item
the patients signed the written informed consent.
boolean
C0021430 (UMLS CUI [1])
Invasive carcinoma of breast Operable | Distant metastasis Absent
Item
the patients present with histologically proven operable invasive breast cancers without distant metastasis.
boolean
C0853879 (UMLS CUI [1,1])
C0205188 (UMLS CUI [1,2])
C1269798 (UMLS CUI [2,1])
C0332197 (UMLS CUI [2,2])
Oestrogen receptor positive breast cancer Immunohistochemistry | Breast Carcinoma Progesterone receptor positive Immunohistochemistry | Breast Carcinoma Estrogen Receptor beta Positive Immunohistochemistry
Item
the breast tumor's positive er/pr rate is <1%, and positive er-beta rate is ≥1% by immuno-histochemistry(ihc).
boolean
C2938924 (UMLS CUI [1,1])
C0021044 (UMLS CUI [1,2])
C0678222 (UMLS CUI [2,1])
C0279759 (UMLS CUI [2,2])
C0021044 (UMLS CUI [2,3])
C0678222 (UMLS CUI [3,1])
C0529099 (UMLS CUI [3,2])
C1514241 (UMLS CUI [3,3])
C0021044 (UMLS CUI [3,4])
Hormone Therapy Neoadjuvant Absent
Item
the patients have no history of neoadjuvant hormone therapy.
boolean
C0279025 (UMLS CUI [1,1])
C0600558 (UMLS CUI [1,2])
C0332197 (UMLS CUI [1,3])
Karnofsky Performance Status
Item
the patients' karnofsky performance score ≥70%.
boolean
C0206065 (UMLS CUI [1])
Gender Age
Item
female patient who is ≥ 18yrs, and ≤ 80yrs.
boolean
C0079399 (UMLS CUI [1,1])
C0001779 (UMLS CUI [1,2])
Pregnancy Absent | Contraceptive methods
Item
the patients are non-pregnant, and disposed to practice contraception during the whole trial.
boolean
C0032961 (UMLS CUI [1,1])
C0332197 (UMLS CUI [1,2])
C0700589 (UMLS CUI [2])
Chemotherapy Neo-adjuvant | Operative Surgical Procedures | Modified radical mastectomy Directly | Breast-Conserving Surgery | Sentinel Lymph Node Biopsy | Excision of axillary lymph nodes | Status post Diagnosis Breast Carcinoma
Item
the patients underwent neoadjuvant chemotherapy plus surgery or directly modified radical mastectomy or breast-conserving surgery (plus sentinel lymph node biopsy or axillary lymph node dissection) after diagnosis of breast cancer.
boolean
C0392920 (UMLS CUI [1,1])
C1298676 (UMLS CUI [1,2])
C0543467 (UMLS CUI [2])
C0024883 (UMLS CUI [3,1])
C1947931 (UMLS CUI [3,2])
C0917927 (UMLS CUI [4])
C0796693 (UMLS CUI [5])
C0193867 (UMLS CUI [6])
C0231290 (UMLS CUI [7,1])
C0011900 (UMLS CUI [7,2])
C0678222 (UMLS CUI [7,3])
Chemotherapy | Therapeutic radiology procedure | Status post Operative Surgical Procedures
Item
the patients underwent chemotherapy, radiation therapy after surgery according to the 2013 nccn guideline.
boolean
C0392920 (UMLS CUI [1])
C1522449 (UMLS CUI [2])
C0231290 (UMLS CUI [3,1])
C0543467 (UMLS CUI [3,2])
Hematologic Tests
Item
the results of patients' blood tests are as follows:
boolean
C0018941 (UMLS CUI [1])
Hemoglobin measurement | White Blood Cell Count procedure | Neutrophil count | Platelet Count measurement | Alanine aminotransferase measurement | Aspartate aminotransferase measurement | Serum total bilirubin measurement
Item
hb≥90g/l; wbc≥4.0×109/l; neutrophils≥1.5×109/l; plt≥100×109/l; alanine aminotransferase(alt) and aspartate aminotransferase (ast) ≤ 2.5 × upper limit of normal(uln); total bilirubin(tbil) ≤ 1.5×uln; creatinine ≤ 1.25×uln.
boolean
C0518015 (UMLS CUI [1])
C0023508 (UMLS CUI [2])
C0200633 (UMLS CUI [3])
C0032181 (UMLS CUI [4])
C0201836 (UMLS CUI [5])
C0201899 (UMLS CUI [6])
C1278039 (UMLS CUI [7])
Malignant disease Invasive | Breast Carcinoma | Cancer Other | Exception Squamous cell carcinoma of skin | Exception Basal cell carcinoma | Exception Conization Carcinoma in situ of uterine cervix
Item
the patients have a previous history of invasive malignant disease (breast cancer at any time, other malignant disorders within the past 10 years excluding squamous or basal-cell carcinoma of the skin or carcinoma in situ of the cervix, adequately cone biopsied).
boolean
C0442867 (UMLS CUI [1,1])
C0205281 (UMLS CUI [1,2])
C0678222 (UMLS CUI [2])
C1707251 (UMLS CUI [3])
C1705847 (UMLS CUI [4,1])
C0553723 (UMLS CUI [4,2])
C1705847 (UMLS CUI [5,1])
C0007117 (UMLS CUI [5,2])
C1705847 (UMLS CUI [6,1])
C0195324 (UMLS CUI [6,2])
C0851140 (UMLS CUI [6,3])
Comorbidity Severe At risk Patient | Comorbidity Severe Interferes with Research results
Item
the patients have any severe concomitant disease which will place the patient at unusual risk or confound the results of the trial.
boolean
C0009488 (UMLS CUI [1,1])
C0205082 (UMLS CUI [1,2])
C1444641 (UMLS CUI [1,3])
C0030705 (UMLS CUI [1,4])
C0009488 (UMLS CUI [2,1])
C0205082 (UMLS CUI [2,2])
C0521102 (UMLS CUI [2,3])
C0683954 (UMLS CUI [2,4])
Hormone Therapy Neoadjuvant
Item
the patients have history of neoadjuvant hormone therapy.
boolean
C0279025 (UMLS CUI [1,1])
C0600558 (UMLS CUI [1,2])
Cancer treatment | Study Subject Participation Status | Clinical Trial
Item
the patients are undergoing current administration of anti-cancer therapies, or are attending other clinical trials.
boolean
C0920425 (UMLS CUI [1])
C2348568 (UMLS CUI [2])
C0008976 (UMLS CUI [3])
Pregnancy | Breast Feeding | Contraceptive methods Refused
Item
the patients are pregnant or lactational, or they refuse to practice contraception during the whole trial.
boolean
C0032961 (UMLS CUI [1])
C0006147 (UMLS CUI [2])
C0700589 (UMLS CUI [3,1])
C1705116 (UMLS CUI [3,2])
Hormone drug Discontinue Unwilling | Hormone replacement therapy Discontinue Unwilling
Item
the patients are unwilling to stop any hormonal drug including hormone replacement therapy(hrt).
boolean
C0019932 (UMLS CUI [1,1])
C1444662 (UMLS CUI [1,2])
C0558080 (UMLS CUI [1,3])
C0282402 (UMLS CUI [2,1])
C1444662 (UMLS CUI [2,2])
C0558080 (UMLS CUI [2,3])
Informed Consent Comprehension Unable | Dementia
Item
the patients can't understand the written informed consent; such as they have dementia.
boolean
C0021430 (UMLS CUI [1,1])
C0162340 (UMLS CUI [1,2])
C1299582 (UMLS CUI [1,3])
C0497327 (UMLS CUI [2])
Hypersensitivity Toremifene | Medical contraindication Toremifene | Hypersensitivity Anastrozole | Medical contraindication Anastrozole
Item
the patients have allergic history or contraindication of toremifene/anastrozole.
boolean
C0020517 (UMLS CUI [1,1])
C0076836 (UMLS CUI [1,2])
C1301624 (UMLS CUI [2,1])
C0076836 (UMLS CUI [2,2])
C0020517 (UMLS CUI [3,1])
C0290883 (UMLS CUI [3,2])
C1301624 (UMLS CUI [4,1])
C0290883 (UMLS CUI [4,2])