Liver carcinoma
Item
patients with hepatocellular carcinoma are eligible for this trial.
boolean
C2239176 (UMLS CUI [1])
Inclusion criteria Quantity Fulfill
Item
hepatocellular carcinoma is defined as having at least one of the following:
boolean
C1512693 (UMLS CUI [1,1])
C1265611 (UMLS CUI [1,2])
C1550543 (UMLS CUI [1,3])
Liver carcinoma Biopsy | Liver neoplasm discrete BCLC Stage | Tumor size | Arteries hypervascular | Phase Venous Washout | Phase Delayed Washout | Computed Tomography | MRI
Item
biopsy proven hepatocellular carcinoma (hcc); or a discrete hepatic tumor(s) as defined by the barcelona (29) criteria for cirrhotic patients, >2cm with arterial hypervascularity and venous or delayed phase washout on ct or mri.
boolean
C2239176 (UMLS CUI [1,1])
C0005558 (UMLS CUI [1,2])
C0023903 (UMLS CUI [2,1])
C0443299 (UMLS CUI [2,2])
C3899974 (UMLS CUI [2,3])
C0475440 (UMLS CUI [3])
C0003842 (UMLS CUI [4,1])
C1512560 (UMLS CUI [4,2])
C0205390 (UMLS CUI [5,1])
C0348013 (UMLS CUI [5,2])
C1710661 (UMLS CUI [5,3])
C0205390 (UMLS CUI [6,1])
C0205421 (UMLS CUI [6,2])
C1710661 (UMLS CUI [6,3])
C0040405 (UMLS CUI [7])
C0024485 (UMLS CUI [8])
Ccriteria Fulfill Transplantation of liver | Patient on waiting list Orthotopic liver transplant
Item
patient is within milan criteria and "listed" for orthotopic liver transplantation.
boolean
C0243161 (UMLS CUI [1,1])
C1550543 (UMLS CUI [1,2])
C0023911 (UMLS CUI [1,3])
C0422768 (UMLS CUI [2,1])
C0400447 (UMLS CUI [2,2])
Zubrod Performance Status
Item
patients must have a zubrod performance status of ≤2.
boolean
C3714786 (UMLS CUI [1])
Life Expectancy
Item
patients must have a life expectancy of at least 12 weeks.
boolean
C0023671 (UMLS CUI [1])
Age | Adult | Gender | Racial group All
Item
patients must be 18 years of age or older. adult patients of all ages, both sexes and all races will be included in this study.
boolean
C0001779 (UMLS CUI [1])
C0001675 (UMLS CUI [2])
C0079399 (UMLS CUI [3])
C0034510 (UMLS CUI [4,1])
C0444868 (UMLS CUI [4,2])
Child-Pugh-Turcotte score
Item
patients must be child-turcotte-pugh (ctp) class a or class b (≤ 7).
boolean
C3854424 (UMLS CUI [1])
Childbearing Potential Pregnancy Absent | Females & males of reproductive potential Contraceptive methods | Childbearing Potential Urine pregnancy test | Childbearing Potential Serum pregnancy test
Item
female patients within reproductive years may not be, nor become, pregnant during participation in this study. both male and female patients within reproductive years must agree to use an effective contraceptive method during treatment. women of childbearing age will be required to undergo a urine or serum pregnancy test to ensure they are not pregnant.
boolean
C3831118 (UMLS CUI [1,1])
C0032961 (UMLS CUI [1,2])
C0332197 (UMLS CUI [1,3])
C4034483 (UMLS CUI [2,1])
C0700589 (UMLS CUI [2,2])
C3831118 (UMLS CUI [3,1])
C0430056 (UMLS CUI [3,2])
C3831118 (UMLS CUI [4,1])
C0430064 (UMLS CUI [4,2])
Organ function | Bone Marrow function | Platelet Count measurement | Renal function | Blood urea nitrogen measurement | Creatinine measurement, serum | Liver function | International Normalized Ratio | Vitamin K | Exception Anticoagulation Therapy | Serum total bilirubin measurement | Obstruction of biliary tree Absent | Biliary Tract Disease Absent | Primary sclerosing cholangitis Absent | Liver Volume
Item
patients must have adequate organ function within 2 weeks of enrollment. bone marrow: platelets ≥30,000/mm3 renal: bun ≤40 mg/dl; creatinine ≤2.0 mg/dl hepatic: inr ≤ 1.5 or correctable by vitamin k, unless anti- coagulated for another medical reason bilirubin < 3 mg/dl (in the absence of obstruction or pre-existing disease of the biliary tract, e.g. primary sclerosing cholangitis) patients uninvolved liver volume will be estimated and must be > 700ml.
boolean
C0678852 (UMLS CUI [1])
C0005953 (UMLS CUI [2,1])
C0031843 (UMLS CUI [2,2])
C0032181 (UMLS CUI [3])
C0232804 (UMLS CUI [4])
C0005845 (UMLS CUI [5])
C0201976 (UMLS CUI [6])
C0232741 (UMLS CUI [7])
C0525032 (UMLS CUI [8])
C0042878 (UMLS CUI [9])
C1705847 (UMLS CUI [10,1])
C0003281 (UMLS CUI [10,2])
C1278039 (UMLS CUI [11])
C0400979 (UMLS CUI [12,1])
C0332197 (UMLS CUI [12,2])
C0005424 (UMLS CUI [13,1])
C0332197 (UMLS CUI [13,2])
C0566602 (UMLS CUI [14,1])
C0332197 (UMLS CUI [14,2])
C0023884 (UMLS CUI [15,1])
C0449468 (UMLS CUI [15,2])
Informed Consent
Item
patients must sign an informed consent form approved for this purpose by the institutional review board (irb) of the lahey hospital and medical center indicating that they are aware of the investigational aspects of the treatment and the potential risks.
boolean
C0021430 (UMLS CUI [1])
Age | Pregnancy | Prisoners
Item
patients in a "special category" designated the public health service, including patients younger than 18, pregnant women, and prisoners.
boolean
C0001779 (UMLS CUI [1])
C0032961 (UMLS CUI [2])
C0033167 (UMLS CUI [3])
Refractory ascites | Ascites Requirement Paracentesis
Item
refractory ascites or ascites that requires paracentesis for management.
boolean
C3532188 (UMLS CUI [1])
C0003962 (UMLS CUI [2,1])
C1514873 (UMLS CUI [2,2])
C0034115 (UMLS CUI [2,3])
Lesion solitary Size | Lesion discrete Quantity | Lesion Largest Size
Item
patients with a solitary lesion greater than 5.0cm in size or more than 2 discrete lesions the largest greater than 3.0 cm in size.
boolean
C0221198 (UMLS CUI [1,1])
C0205171 (UMLS CUI [1,2])
C0456389 (UMLS CUI [1,3])
C0221198 (UMLS CUI [2,1])
C0443299 (UMLS CUI [2,2])
C1265611 (UMLS CUI [2,3])
C0221198 (UMLS CUI [3,1])
C0443228 (UMLS CUI [3,2])
C0456389 (UMLS CUI [3,3])
Hypersensitivity Iodinated contrast dye Intravenous | Unresponsive to Prednisone Pretreatment
Item
known allergy to intravenous iodinated contrast agents unresponsive to prednisone pre-treatment.
boolean
C0020517 (UMLS CUI [1,1])
C0879373 (UMLS CUI [1,2])
C1522726 (UMLS CUI [1,3])
C0205269 (UMLS CUI [2,1])
C0032952 (UMLS CUI [2,2])
C3539076 (UMLS CUI [2,3])