Hypertensive disease | Tachycardia
Item
subjects with high blood pressure (bp) and tachycardia
boolean
C0020538 (UMLS CUI [1])
C0039231 (UMLS CUI [2])
Hypotension Essential | Angina Pectoris
Item
subjects with essential hypotonia, angina pectoris
boolean
C0020649 (UMLS CUI [1,1])
C0205224 (UMLS CUI [1,2])
C0002962 (UMLS CUI [2])
Essential Hypertension | Adrenergic beta-1 Receptor Antagonists ineffective | Diuretics ineffective
Item
subjects with essential hypertonia, when a therapy with ß-blockers or diuretics is not sufficiently effective
boolean
C0085580 (UMLS CUI [1])
C0304516 (UMLS CUI [2,1])
C3242229 (UMLS CUI [2,2])
C0012798 (UMLS CUI [3,1])
C3242229 (UMLS CUI [3,2])
Precautions | Poor peripheral circulation | Diabetes Mellitus | Metabolic acidosis | First degree atrioventricular block | Angina Pectoris, Variant | Angiotensin-Converting Enzyme Inhibitors | Coronary Arteriosclerosis Severe | Tuberous Sclerosis Severe | Hyperuricemia | Gout | Allergic Reaction Severe | Hypersensitivity desensitization | Anaphylaxis Excessive | Other Coding
Item
precautions to be taken in case of severe peripheral circulation disorders, diabetes (especially at the time, when blood sugar is elevated), during a strict fast, in case of metabolic acidosis, atrioventricular block (av) block of grade i, prinzmetal angina, additional therapy with angiotensin-converting enzyme inhibitors (ace-inhibitors), severe coronary or cerebral sclerosis, hyperuricemia or gout and in subjects with a history of severe hypersensitive reactions or during a desensitization therapy (excessive anaphylactic reaction, attenuated adrenergic counterregulation)
boolean
C1882442 (UMLS CUI [1])
C0520547 (UMLS CUI [2])
C0011849 (UMLS CUI [3])
C0220981 (UMLS CUI [4])
C0085614 (UMLS CUI [5])
C0002963 (UMLS CUI [6])
C0003015 (UMLS CUI [7])
C0010054 (UMLS CUI [8,1])
C0205082 (UMLS CUI [8,2])
C0041341 (UMLS CUI [9,1])
C0205082 (UMLS CUI [9,2])
C0740394 (UMLS CUI [10])
C0018099 (UMLS CUI [11])
C1527304 (UMLS CUI [12,1])
C0205082 (UMLS CUI [12,2])
C0178702 (UMLS CUI [13])
C0002792 (UMLS CUI [14,1])
C0442802 (UMLS CUI [14,2])
C3846158 (UMLS CUI [15])
Precautions Special | Family history Psoriasis | Psoriasis | Lung Diseases, Obstructive | Bronchoconstriction | Adrenergic beta-1 Receptor Antagonists | Concor | Pheochromocytoma
Item
special precautions must be taken with the subjects that have a family history or suffered from psoriasis, during a desensitization therapy (also anamnestic subjects), other obstructive pulmonary diseases on account of the possibility of initiation or intensification of bronchoconstriction, although, due to the marked ß1-selectivity of bisoprolol, the risk is lower than with non-selective ß-receptor blockers. the subjects that have a family history or suffered from psoriasis should the take concor plus only after a careful assessment of risk - benefit ratio. the subjects with pheochromocytoma should take concor plus, as well as other ß-blockers after inhibiting the alpha-receptors
boolean
C1882442 (UMLS CUI [1,1])
C0205555 (UMLS CUI [1,2])
C0455439 (UMLS CUI [2])
C0033860 (UMLS CUI [3])
C0600260 (UMLS CUI [4])
C0079043 (UMLS CUI [5])
C0304516 (UMLS CUI [6])
C0110591 (UMLS CUI [7])
C0031511 (UMLS CUI [8])
Heart failure | Sick Sinus Syndrome | Bradycardia | Anemia
Item
subjects with acute cardiac insufficiency, sinus sick syndrome, bradycardia and anaemia
boolean
C0018801 (UMLS CUI [1])
C0037052 (UMLS CUI [2])
C0428977 (UMLS CUI [3])
C0002871 (UMLS CUI [4])
Medical condition Contraindicated Bisoprolol | Hypersensitivity Bisoprolol | Hypersensitivity Inactive ingredient Medication | Heart failure | Decompensated cardiac failure | Requirement Inotropic agent | Shock, Cardiogenic | Second degree atrioventricular block | Complete atrioventricular block | Artificial cardiac pacemaker Absent | Sick Sinus Syndrome | Sinoatrial Block | BRADYCARDIA SYMPTOMATIC | Hypotension symptomatic | Severe asthma | Severe chronic obstructive pulmonary disease | Peripheral Arterial Disease Advanced | Raynaud Disease | Pheochromocytoma Untreated | Metabolic acidosis
Item
contraindicated medical conditions for bisoprolol as defined in the product information, i.e. a known hypersensitivity to the active agent bisoprolol or one of the inactive ingredients of the medication; acute heart failure or decompensation of heart insufficiency, that requires a therapy with inotropic agents; cardiogenic shock; av block grade ii or iii (in the absence of cardiac pacemakers); sick sinus syndrome, sinoatrial heart block; symptomatic bradycardia; symptomatic hypotonia; severe asthma bronchiolus or severe chronic obstructive airways disease; advanced stages of peripheral arterial disease or raynaud's syndrome; untreated pheochromocytoma, metabolic acidosis
boolean
C3843040 (UMLS CUI [1,1])
C1444657 (UMLS CUI [1,2])
C0053799 (UMLS CUI [1,3])
C0020517 (UMLS CUI [2,1])
C0053799 (UMLS CUI [2,2])
C0020517 (UMLS CUI [3,1])
C1552019 (UMLS CUI [3,2])
C0013227 (UMLS CUI [3,3])
C0018801 (UMLS CUI [4])
C0581377 (UMLS CUI [5])
C1514873 (UMLS CUI [6,1])
C0304509 (UMLS CUI [6,2])
C0036980 (UMLS CUI [7])
C0264906 (UMLS CUI [8])
C0151517 (UMLS CUI [9])
C0030163 (UMLS CUI [10,1])
C0332197 (UMLS CUI [10,2])
C0037052 (UMLS CUI [11])
C0037188 (UMLS CUI [12])
C0741627 (UMLS CUI [13])
C0863113 (UMLS CUI [14])
C0581126 (UMLS CUI [15])
C0730607 (UMLS CUI [16])
C1704436 (UMLS CUI [17,1])
C0205179 (UMLS CUI [17,2])
C0034734 (UMLS CUI [18])
C0031511 (UMLS CUI [19,1])
C0332155 (UMLS CUI [19,2])
C0220981 (UMLS CUI [20])
Medical condition Contraindicated Bisoprolol / Hydrochlorothiazide | Hypersensitivity Bisoprolol / Hydrochlorothiazide | Heart failure Uncompensated | Pulmonary Hypertension | Shock, Cardiogenic | Second degree atrioventricular block | Complete atrioventricular block | Sick Sinus Syndrome | Artificial cardiac pacemaker Absent | Sinoatrial Block | Bradycardia, severe | Hypotension | Systolic Pressure | Asthma attack | Verapamil Intravenous | Monoamine Oxidase Inhibitors | Poor peripheral circulation Advanced phase | Potassium Deficiency Treatment Resistant Severe | Hyponatremia Severe | Hypercalcemia | Renal dysfunction Severe | Creatinine measurement, serum | Creatinine clearance measurement | Glomerulonephritis | Hepatic Coma | Children Untreated | Pregnancy | Breast Feeding
Item
contraindicated medical conditions for bisoprolol + hydrochlorothiazide (hctz) as defined in the product information, i.e. hypersensitivity to the ingredients of the medication containing bisoprolol + hctz, uncompensated heart insufficiency, pulmonary hypertension, cardiogenic shock, av block, grades ii and iii. sick sinus syndrome (in the absence of cardiac pacemakers), sinoatrial heart block, severe bradycardia with less than 50 beats/min from the start of treatment, hypotension(systolic less than 90 mmhg), acute asthmatic attack, intravenous administration of calcium antagonists of verapamil type, simultaneous treatment with monoamine oxidase inhibitors (mao-inhibitors), advanced stages of peripheral circulation disorder, severe therapy-resistant potassium deficiency, severe hyponatraemia, hypercalcaemia, severe renal dysfunction (serum creatinin over 1.8 mg/100 ml and/or creatinin clearance under 30 ml/min); acute glomerulonephritis; liver coma; children, not previously treated; pregnancy and breastfeeding
boolean
C3843040 (UMLS CUI [1,1])
C1444657 (UMLS CUI [1,2])
C0717511 (UMLS CUI [1,3])
C0020517 (UMLS CUI [2,1])
C0717511 (UMLS CUI [2,2])
C0018801 (UMLS CUI [3,1])
C0205433 (UMLS CUI [3,2])
C0020542 (UMLS CUI [4])
C0036980 (UMLS CUI [5])
C0264906 (UMLS CUI [6])
C0151517 (UMLS CUI [7])
C0037052 (UMLS CUI [8])
C0030163 (UMLS CUI [9,1])
C0332197 (UMLS CUI [9,2])
C0037188 (UMLS CUI [10])
C4313412 (UMLS CUI [11])
C0020649 (UMLS CUI [12])
C0871470 (UMLS CUI [13])
C0347950 (UMLS CUI [14])
C0042523 (UMLS CUI [15,1])
C1522726 (UMLS CUI [15,2])
C0026457 (UMLS CUI [16])
C0520547 (UMLS CUI [17,1])
C0205179 (UMLS CUI [17,2])
C0032827 (UMLS CUI [18,1])
C0871547 (UMLS CUI [18,2])
C0205082 (UMLS CUI [18,3])
C0020625 (UMLS CUI [19,1])
C0205082 (UMLS CUI [19,2])
C0020437 (UMLS CUI [20])
C3279454 (UMLS CUI [21,1])
C0205082 (UMLS CUI [21,2])
C0201976 (UMLS CUI [22])
C0373595 (UMLS CUI [23])
C0017658 (UMLS CUI [24])
C0019147 (UMLS CUI [25])
C0008059 (UMLS CUI [26,1])
C0332155 (UMLS CUI [26,2])
C0032961 (UMLS CUI [27])
C0006147 (UMLS CUI [28])