Age
Item
patient >= 45 years .
boolean
C0001779 (UMLS CUI [1])
Primary osteoarthritis of knee ACR Criteria
Item
primary oa of the knee according to acr criteria.
boolean
C2893931 (UMLS CUI [1,1])
C3273747 (UMLS CUI [1,2])
Osteoarthritis Kellgren-Lawrence score Radiology
Item
oa radiological grade ii-iii according to kellgren and lawrence.
boolean
C0029408 (UMLS CUI [1,1])
C3177117 (UMLS CUI [1,2])
C0043299 (UMLS CUI [1,3])
Moderate pain | Severe pain
Item
patients with moderate-severe pain.
boolean
C0278139 (UMLS CUI [1])
C0278140 (UMLS CUI [2])
Trauma Target Knee | Operative Surgical Procedure Target Knee
Item
patients with clinical significant trauma or surgery in the target knee.
boolean
C3714660 (UMLS CUI [1,1])
C1521840 (UMLS CUI [1,2])
C0022742 (UMLS CUI [1,3])
C0543467 (UMLS CUI [2,1])
C1521840 (UMLS CUI [2,2])
C0022742 (UMLS CUI [2,3])
Arthritis Concurrent Interferes with Evaluation | Chondrocalcinosis | Paget's disease Limb Ipsilateral | Rheumatoid Arthritis | Osteonecrosis aseptic | Gout | Arthritis, Infectious | Ochronosis | Acromegaly | Hemochromatosis | Wilson's disease | Osteochondromatosis | Spondylarthropathy Seronegative | Mixed Connective Tissue Disease | Collagen-vascular disease | Psoriasis | Inflammatory Bowel Disease | Fibromyalgia
Item
concurrent arthritic disease (antecedents and/or current signs) that could confound or interfere with the evaluation of pain efficacy such as chondrocalcinosis, paget's disease of the ipsilateral limb to the target knee, rheumatoid arthritis, aseptic osteonecrosis, gout, septic arthritis, ochronosis, acromegaly, haemochromatosis, wilson's disease, osteochondromatosis, seronegative spondyloarthropathy, mixed connective tissue disease, collagen vascular disease, psoriasis, inflammatory bowel disease or fibromyalgia.
boolean
C0003864 (UMLS CUI [1,1])
C0205420 (UMLS CUI [1,2])
C0521102 (UMLS CUI [1,3])
C0220825 (UMLS CUI [1,4])
C0221621 (UMLS CUI [2])
C0029401 (UMLS CUI [3,1])
C0015385 (UMLS CUI [3,2])
C0441989 (UMLS CUI [3,3])
C0003873 (UMLS CUI [4])
C0391980 (UMLS CUI [5])
C0018099 (UMLS CUI [6])
C0003869 (UMLS CUI [7])
C0028817 (UMLS CUI [8])
C0001206 (UMLS CUI [9])
C0018995 (UMLS CUI [10])
C0019202 (UMLS CUI [11])
C0206641 (UMLS CUI [12])
C0949691 (UMLS CUI [13,1])
C0521144 (UMLS CUI [13,2])
C0026272 (UMLS CUI [14])
C0262428 (UMLS CUI [15])
C0033860 (UMLS CUI [16])
C0021390 (UMLS CUI [17])
C0016053 (UMLS CUI [18])
Pain Except Knee pain | Pain Interferes with Evaluation
Item
pain in other parts of the body greater than the knee pain that could interfere with the evaluation.
boolean
C0030193 (UMLS CUI [1,1])
C0332300 (UMLS CUI [1,2])
C0231749 (UMLS CUI [1,3])
C0030193 (UMLS CUI [2,1])
C0521102 (UMLS CUI [2,2])
C1261322 (UMLS CUI [2,3])
Communicable Diseases Requirement Antibiotics | Chronic infectious disease Requirement Antibiotics | Virus Diseases Serious | Hepatitis | Herpes zoster | HIV Seropositivity | Mycoses Serious
Item
subjects with any active acute or chronic infections requiring antimicrobial therapy, or serious viral (e.g., hepatitis, herpes zoster, hiv positivity) or fungal infections.
boolean
C0009450 (UMLS CUI [1,1])
C1514873 (UMLS CUI [1,2])
C0003232 (UMLS CUI [1,3])
C0151317 (UMLS CUI [2,1])
C1514873 (UMLS CUI [2,2])
C0003232 (UMLS CUI [2,3])
C0042769 (UMLS CUI [3,1])
C0205404 (UMLS CUI [3,2])
C0019158 (UMLS CUI [4])
C0019360 (UMLS CUI [5])
C0019699 (UMLS CUI [6])
C0026946 (UMLS CUI [7,1])
C0205404 (UMLS CUI [7,2])
Diabetic - poor control
Item
clinical diagnosis established of uncontrolled diabetes mellitus.
boolean
C0421258 (UMLS CUI [1])
Asthma
Item
patients with asthma.
boolean
C0004096 (UMLS CUI [1])
Hypersensitivity Investigational New Drugs | Hypersensitivity Investigational New Drugs Excipients
Item
history of hypersensitivity to the active drugs or any excipients of the formulations.
boolean
C0020517 (UMLS CUI [1,1])
C0013230 (UMLS CUI [1,2])
C0020517 (UMLS CUI [2,1])
C0013230 (UMLS CUI [2,2])
C0015237 (UMLS CUI [2,3])